Primary Site >> Liver Cancer

Gene >> LEPR

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Ref: Potential prognostic value of leptin receptor in hepatocellular carcinoma.
PMID: 16565226
Ref: Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +(db)/+Lepr(db) mice.
PMID: 21071580
Ref: Role of leptin receptor (LEPR) gene polymorphisms and haplotypes in susceptibility to hepatocellular carcinoma in subjects with chronic hepatitis B virus infection.
PMID: 23090836
Ref: Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma.
PMID: 24379610
Ref: Leptin receptor somatic mutations are frequent in HCV-infected cirrhotic liver and associated with hepatocellular carcinoma.
PMID: 24055508
Ref: Pentoxifylline prevents nonalcoholic steatohepatitis-related liver pre-neoplasms by inhibiting hepatic inflammation and lipogenesis.
PMID: 26258810
Ref: Hepatoma cell-derived leptin downregulates the immunosuppressive function of regulatory T-cells to enhance the anti-tumor activity of CD8+ T-cells.
PMID: 26639061
Ref: Hepatic DNA hydroxymethylation is site-specifically altered by chronic alcohol consumption and aging.
PMID: 26578530
Ref: Concurrent fatty liver increases risk of hepatocellular carcinoma among patients with chronic hepatitis B.
PMID: 27547913
Ref: Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic mice.
PMID: 28938561
Ref: Investigation of LEP and LEPR polymorphisms with the risk of hepatocellular carcinoma: a case-control study in Eastern Chinese Han population.
PMID: 29695916
Ref: Hepatic leptin receptor expression can partially compensate for IL-6Ralpha deficiency in DEN-induced hepatocellular carcinoma.
PMID: 30224299