Primary Site >> Colorectal Cancer
Gene >> LEPR
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Ref: Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways. PMID: 11053255 |
Ref: Expression of the obesity hormone leptin and its receptor correlates with hypoxia-inducible factor-1 alpha in human colorectal cancer. PMID: 17591803 |
Ref: Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. PMID: 18059035 |
Ref: Obesity-related genes variability in Czech patients with sporadic colorectal cancer: preliminary results. PMID: 18704460 Ref: Genetic variation in adipokine genes and risk of colorectal cancer. PMID: 19273568 Ref: Leptin receptor expression in Middle Eastern colorectal cancer and its potential clinical implication. PMID: 19520793 |
Ref: Obesity hormone leptin induces growth and interferes with the cytotoxic effects of 5-fluorouracil in colorectal tumor stem cells. PMID: 20603394 Ref: Insulin glargine and NPH insulin increase to a similar degree epithelial cell proliferation and aberrant crypt foci formation in colons of diabetic mice. PMID: 21761363 |
Ref: Expression and biological significance of leptin, leptin receptor, VEGF, and CD34 in colorectal carcinoma. PMID: 21161731 Ref: Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis. PMID: 21406387 Ref: Association of leptin receptor gene Gln223Arg polymorphism with susceptibility to colorectal cancer. PMID: 24834182 |
Ref: Effects of diet-induced obesity on colitis-associated colon tumor formation in A/J mice. PMID: 21544082 Ref: Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway. PMID: 22357207 |
Ref: Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer. PMID: 23558862 Ref: Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity. PMID: 23567149 Ref: The leptin gene family and colorectal cancer: interaction with smoking behavior and family history of cancer. PMID: 23593308 Ref: Plasma C-reactive protein, genetic risk score, and risk of common cancers in the Atherosclerosis Risk in Communities study. PMID: 24036889 Ref: The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer. PMID: 25250132 |
Ref: Oncogenic role and therapeutic target of leptin signaling in colorectal cancer. PMID: 24946986 Ref: Conditional knockout of the leptin receptor in the colonic epithelium revealed the local effects of leptin receptor signaling in the progression of colonic tumors in mice. PMID: 24958593 Ref: Preventive effects of the angiotensin-converting enzyme inhibitor, captopril, on the development of azoxymethane-induced colonic preneoplastic lesions in diabetic and hypertensive rats. PMID: 24959250 Ref: Carnosic acid suppresses colon tumor formation in association with antiadipogenic activity. PMID: 25204550 Ref: Lack of association between LEPR Q223R polymorphisms and cancer susceptibility: evidence from a meta-analysis. PMID: 25261679 |
Ref: Involvement of leptin receptors expression in proliferation and neoangiogenesis in colorectal carcinoma. PMID: 25778303 |
Ref: Diet- and Genetically-induced Obesity Produces Alterations in the Microbiome, Inflammation and Wnt Pathway in the Intestine of Apc(+/1638N) Mice: Comparisons and Contrasts. PMID: 27698916 Ref: Genetic Variations in Leptin and Leptin Receptor and Susceptibility to Colorectal Cancer and Obesity. PMID: 27703650 |
Ref: Upregulation of the adipokine genes ADIPOR1 and SPP1 is related to poor survival outcomes in colorectal cancer. PMID: 29761507 |