Primary Site >> Colorectal Cancer
Gene >> LEF1
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Ref: Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin. PMID: 9419974 |
Ref: Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin. PMID: 9628899 Ref: Beta-catenin mutation in carcinoma of the uterine endometrium. PMID: 9721853 |
Ref: A common human skin tumour is caused by activating mutations in beta-catenin. PMID: 10192393 |
Ref: Expression of prostaglandin endoperoxide H synthase-2 induced by nitric oxide in conditionally immortalized murine colonic epithelial cells. PMID: 10834941 Ref: Differential formation of beta-catenin/lymphoid enhancer factor-1 DNA binding complex induced by nitric oxide in mouse colonic epithelial cells differing in adenomatous polyposis coli (Apc) genotype. PMID: 10910042 |
Ref: The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors. PMID: 11158322 Ref: Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. PMID: 11326276 Ref: Tyrosine phosphorylation translocates beta-catenin from cell-->cell interface to the cytoplasm, but does not significantly enhance the LEF-1-dependent transactivating function. PMID: 11401329 |
Ref: Lymphoid enhancer factor-1 blocks adenomatous polyposis coli-mediated nuclear export and degradation of beta-catenin. Regulation by histone deacetylase 1. PMID: 11986304 Ref: Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells. PMID: 12077367 Ref: Genomic effects of polyamide/DNA interactions on mRNA expression. PMID: 12144926 Ref: Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. PMID: 12183361 Ref: Expression of lymphoid enhancer factor/T-cell factor proteins in colon cancer. PMID: 17031231 |
Ref: A new beta-catenin-dependent activation domain in T cell factor. PMID: 12582159 Ref: Wnt signaling during development of the gastrointestinal tract. PMID: 12871700 Ref: Transcriptional regulation of cyclo-oxygenase expression: three pillars of control. PMID: 14552705 Ref: Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a. PMID: 14675489 |
Ref: Lymphoid enhancer factor/T cell factor expression in colorectal cancer. PMID: 15000148 Ref: Pharmacological and genetic modulation of Wnt-targeted Cre-Lox-mediated gene expression in colorectal cancer cells. PMID: 15141037 Ref: Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ? PMID: 15245581 Ref: Tissue microarray analysis of cyclin D1 gene amplification and gain in colorectal carcinomas. PMID: 15557752 |
Ref: Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia. PMID: 15735743 Ref: Gastrin stabilises beta-catenin protein in mouse colorectal cancer cells. PMID: 15798764 |
Ref: Wnt activation and alternative promoter repression of LEF1 in colon cancer. PMID: 16809766 |
Ref: Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival. PMID: 17875709 Ref: Putative tumor suppressor EDD interacts with and up-regulates APC. PMID: 18076571 |
Ref: Low concentrations of resveratrol inhibit Wnt signal throughput in colon-derived cells: implications for colon cancer prevention. PMID: 18504708 |
Ref: Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells. PMID: 19067737 Ref: Nuclear signalling by tumour-associated antigen EpCAM. PMID: 19136966 Ref: Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. PMID: 19460168 Ref: The transcriptional activity of Pygopus is enhanced by its interaction with cAMP-response-element-binding protein (CREB)-binding protein. PMID: 19555349 |
Ref: Selective suicide gene therapy of colon cancer cell lines exploiting fibroblast growth factor 18 promoter. PMID: 20187803 Ref: A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer. PMID: 20525792 Ref: WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration. PMID: 20870744 Ref: LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer. PMID: 21092222 |
Ref: Lef1DeltaN binds beta-catenin and increases osteoblast activity and trabecular bone mass. PMID: 21270130 Ref: Comparative profiling of primary colorectal carcinomas and liver metastases identifies LEF1 as a prognostic biomarker. PMID: 21383983 Ref: The Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cells. PMID: 21437251 Ref: [Role of NGX6 in Wnt/beta-catenin signaling pathway in colon cancer]. PMID: 21464545 Ref: Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis. PMID: 21566225 Ref: KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells. PMID: 21890490 Ref: Human FasL gene is a target of beta-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions. PMID: 22022540 |
Ref: S100A6 is transcriptionally regulated by beta-catenin and interacts with a novel target, lamin A/C, in colorectal cancer cells. PMID: 22560296 |
Ref: Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer. PMID: 23267084 Ref: Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1. PMID: 23325550 Ref: Inhibitory effect of a standardized pomegranate fruit extract on Wnt signalling in 1, 2-dimethylhydrazine induced rat colon carcinogenesis. PMID: 23722564 Ref: Knockdown of lymphoid enhancer factor 1 inhibits colon cancer progression in vitro and in vivo. PMID: 24098538 Ref: Increased LEF1 expression and decreased Notch2 expression are strong predictors of poor outcomes in colorectal cancer patients. PMID: 24223455 |
Ref: Allelic imbalance at an 8q24 oncogenic SNP is involved in activating MYC in human colorectal cancer. PMID: 24390711 Ref: LEF1 and B9L shield beta-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors. PMID: 24419084 Ref: The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells. PMID: 24577083 Ref: Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer. PMID: 24609463 Ref: Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation. PMID: 24628919 Ref: Thymine DNA glycosylase promotes transactivation of beta-catenin/TCFs by cooperating with CBP. PMID: 24748645 Ref: MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression. PMID: 24785257 Ref: LEF-1 is frequently expressed in colorectal carcinoma and not in other gastrointestinal tract adenocarcinomas: an immunohistochemical survey of 602 gastrointestinal tract neoplasms. PMID: 25394300 |
Ref: DACT2 is a functional tumor suppressor through inhibiting Wnt/beta-catenin pathway and associated with poor survival in colon cancer. PMID: 25023701 Ref: Oncogenic KRAS signalling promotes the Wnt/beta-catenin pathway through LRP6 in colorectal cancer. PMID: 25500543 Ref: CDH1 POLYMORPHISMS AND LOW EXPRESSION OF E-CADHERIN AND beta-CATENIN IN COLORECTAL CANCER PATIENTS. PMID: 26511186 Ref: The Anti-Tumor Activity of Succinyl Macrolactin A Is Mediated through the beta-Catenin Destruction Complex via the Suppression of Tankyrase and PI3K/Akt. PMID: 26544726 |
Ref: Positive regulation of beta-catenin-PROX1 signaling axis by DBC1 in colon cancer progression. PMID: 26477307 Ref: Topoisomerase IIalpha mediates TCF-dependent epithelial-mesenchymal transition in colon cancer. PMID: 26947016 Ref: Intestinal knockout of Nedd4 enhances growth of Apc(min) tumors. PMID: 27086928 Ref: Wnt/beta-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling. PMID: 27285761 Ref: The anthelmintic niclosamide inhibits colorectal cancer cell lines via modulation of the canonical and noncanonical Wnt signaling pathway. PMID: 27338550 Ref: A novel role for the tumour suppressor Nitrilase1 modulating the Wnt/beta-catenin signalling pathway. PMID: 27462437 Ref: Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing. PMID: 27504909 Ref: Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer. PMID: 27729975 |
Ref: Differential expression of LEF1/TCFs family members in colonic carcinogenesis. PMID: 27433921 Ref: Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation. PMID: 28275297 Ref: Prostaglandin E2-Induced COX-2 Expressions via EP2 and EP4 Signaling Pathways in Human LoVo Colon Cancer Cells. PMID: 28587064 Ref: Tanshinone IIA inhibits beta-catenin/VEGF-mediated angiogenesis by targeting TGF-beta1 in normoxic and HIF-1alpha in hypoxic microenvironments in human colorectal cancer. PMID: 28602978 Ref: Wnt signaling pathway protein LEF1 in cancer, as a biomarker for prognosis and a target for treatment. PMID: 28670499 Ref: microRNA-219-5p inhibits epithelial-mesenchymal transition and metastasis of colorectal cancer by targeting lymphoid enhancer-binding factor 1. PMID: 28771881 Ref: Identification of dysregulated lncRNAs profiling and metastasis-associated lncRNAs in colorectal cancer by genome-wide analysis. PMID: 28857495 Ref: Network analysis based on TCGA reveals hub genes in colon cancer. PMID: 28947883 Ref: Different effection of p.1125Val>Ala and rs11954856 in APC on Wnt signaling pathway. PMID: 29050326 Ref: Upregulation of NETO2 gene in colorectal cancer. PMID: 29297384 |
Ref: The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression. PMID: 29551399 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: DBC1 regulates Wnt/beta-catenin-mediated expression of MACC1, a key regulator of cancer progression, in colon cancer. PMID: 30082743 Ref: An integrated study on TFs and miRNAs in colorectal cancer metastasis and evaluation of three co-regulated candidate genes as prognostic markers. PMID: 30193961 Ref: Elevated G-Protein Receptor 125 (GPR125) Expression Predicts Good Outcomes in Colorectal Cancer and Inhibits Wnt/beta-Catenin Signaling Pathway. PMID: 30231258 Ref: MiR-452 promotes an aggressive colorectal cancer phenotype by regulating a Wnt/beta-catenin positive feedback loop. PMID: 30253791 Ref: Sulforaphane inhibits growth and blocks Wnt/beta-catenin signaling of colorectal cancer cells. PMID: 30338040 Ref: NUP153 overexpression suppresses the proliferation of colorectal cancer by negatively regulating Wnt/beta-catenin signaling pathway and predicts good prognosis. PMID: 30347601 |