Primary Site >> Liver Cancer
Gene >> LECT2
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Ref: Expression pattern of a newly recognized protein, LECT2, in hepatocellular carcinoma and its premalignant lesion. PMID: 10355968 |
Ref: Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas. PMID: 16964294 |
Ref: The tumor suppressor function of LECT2 in human hepatocellular carcinoma makes it a potential therapeutic target. PMID: 21394108 |
Ref: Oncogenic beta-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice. PMID: 22251704 |
Ref: Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment. PMID: 24114941 Ref: Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma. PMID: 24892551 |
Ref: Diverse Basis of beta-Catenin Activation in Human Hepatocellular Carcinoma: Implications in Biology and Prognosis. PMID: 27100093 Ref: Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold. PMID: 27334921 Ref: Inhibition of VEGF165/VEGFR2-dependent signaling by LECT2 suppresses hepatocellular carcinoma angiogenesis. PMID: 27507763 |
Ref: Lect2 controls inflammatory monocytes to constrain the growth and progression of hepatocellular carcinoma. PMID: 30070727 Ref: High Frequency of beta-Catenin Mutations in Mouse Hepatocellular Carcinomas Induced by a Nongenotoxic Constitutive Androstane Receptor Agonist. PMID: 30201494 |