Primary Site >> Liver Cancer
Gene >> KRAS
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Ref: Assignment of three rat cellular RAS oncogenes to chromosomes 1, 4, and X. PMID: 3856333 |
Ref: Mutation analysis of K-ras oncogenes in gastroenterologic cancers by the amplified created restriction sites method. PMID: 8249918 |
Ref: [Detection of c-Ki-ras oncogene codon 12 point mutations in lung carcinoma, gastric carcinoma and hepatic carcinoma]. PMID: 9208596 |
Ref: Manumycin and gliotoxin derivative KT7595 block Ras farnesylation and cell growth but do not disturb lamin farnesylation and localization in human tumour cells. PMID: 9376258 |
Ref: Detection of K-ras point mutations in the supernatants of peritoneal and pleural effusions for diagnosis complementary to cytologic examination. PMID: 9620027 |
Ref: Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. PMID: 12692057 |
Ref: Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. PMID: 16397237 Ref: Immunosuppression promotes reovirus therapy of colorectal liver metastases. PMID: 16543920 |
Ref: Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression. PMID: 18781563 |
Ref: Updates in Gastrointestinal Oncology - insights from the 2008 44th annual meeting of the American Society of Clinical Oncology. PMID: 19236713 Ref: [Two cases of KRAS wild-type unresectable or recurrent colorectal cancer effectively treated by cetuximab after progression of prior chemotherapy]. PMID: 19542725 Ref: Methylation profiling of tumor suppressor genes and oncogenes in hepatitis virus-related hepatocellular carcinoma in northern India. PMID: 19963110 |
Ref: Fulminant plasmapheresis-refractory thrombotic microangiopathy associated with advanced gastric cancer. PMID: 20438546 Ref: Genetic and epigenetic characteristics of human multiple hepatocellular carcinoma. PMID: 20923573 |
Ref: KRAS mutation analysis: a comparison between primary tumours and matched liver metastases in 305 colorectal cancer patients. PMID: 21364579 Ref: Detection of tumor DNA at the margins of colorectal cancer liver metastasis. PMID: 21531819 Ref: Genetics of hepatobiliary carcinogenesis. PMID: 21538283 Ref: Molecular alterations associated with liver metastases development in colorectal cancer patients. PMID: 21673680 Ref: Changing pathology with changing drugs: tumors of the gastrointestinal tract. PMID: 21677471 Ref: A high level of liver-specific expression of oncogenic Kras(V12) drives robust liver tumorigenesis in transgenic zebrafish. PMID: 21729876 Ref: Hepatic carcinoma-associated fibroblasts promote an adaptative response in colorectal cancer cells that inhibit proliferation and apoptosis: nonresistant cells die by nonapoptotic cell death. PMID: 22028619 |
Ref: An inducible kras(V12) transgenic zebrafish model for liver tumorigenesis and chemical drug screening. PMID: 21903676 Ref: Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors. PMID: 22178589 Ref: Phase II trial of erlotinib and docetaxel in advanced and refractory hepatocellular and biliary cancers: Hoosier Oncology Group GI06-101. PMID: 22210086 Ref: Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma. PMID: 22266220 Ref: Relationship between 18F-fluorodeoxyglucose accumulation and KRAS/BRAF mutations in colorectal cancer. PMID: 22282467 Ref: Amphiregulin and Epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases. PMID: 22409860 Ref: Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer. PMID: 22444159 Ref: Comparison of the chemosensitivity of the primary lesion and a pancreatic metastasis of colon cancer: a case report. PMID: 22493386 Ref: KRAS status and outcome of liver resection after neoadjuvant chemotherapy including bevacizumab. PMID: 23027075 |
Ref: Poor prognosis of KRAS or BRAF mutant colorectal liver metastasis without microsatellite instability. PMID: 23010994 Ref: Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes. PMID: 23295441 Ref: Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies. PMID: 23318457 Ref: MicroRNAs in Cancer: the 22nd Hiroshima Cancer Seminar/the 4th Japanese Association for RNA Interference Joint International Symposium, 30 August 2012, Grand Prince Hotel Hiroshima. PMID: 23487440 Ref: Hepatocyte nuclear factor-4alpha reverses malignancy of hepatocellular carcinoma through regulating miR-134 in the DLK1-DIO3 region. PMID: 23775631 Ref: [Consideration of therapy for colorectal cancer with synchronous unresectable liver metastasis]. PMID: 23980038 |
Ref: Prognostic significance of C-reactive protein polymorphism and KRAS/BRAF in synchronous liver metastasis from colorectal cancer. PMID: 23755178 Ref: Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology. PMID: 23792451 Ref: Crosstalk of Ras and Rho: activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models. PMID: 23812423 Ref: Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma. PMID: 24122810 Ref: Synergistic function of Kras mutation and HBx in initiation and progression of hepatocellular carcinoma in mice. PMID: 24213574 Ref: New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing. PMID: 24563076 Ref: FBXW7 mutations in patients with advanced cancers: clinical and molecular characteristics and outcomes with mTOR inhibitors. PMID: 24586741 Ref: Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. PMID: 24633177 Ref: Transcriptomic characterization of hepatocellular carcinoma with CTNNB1 mutation. PMID: 24798046 Ref: Four individually druggable MET hotspots mediate HGF-driven tumor progression. PMID: 24865428 Ref: Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH. PMID: 24880666 Ref: Mutant IDH inhibits HNF-4alpha to block hepatocyte differentiation and promote biliary cancer. PMID: 25043045 Ref: Mutation analysis of key genes in RAS/RAF and PI3K/PTEN pathways in Chinese patients with hepatocellular carcinoma. PMID: 25120700 Ref: Reporting tumor molecular heterogeneity in histopathological diagnosis. PMID: 25127237 Ref: KRAS mutation testing of tumours in adults with metastatic colorectal cancer: a systematic review and cost-effectiveness analysis. PMID: 25314637 Ref: Conversion Therapy Using mFOLFOX6 With Panitumumab for Unresectable Liver Metastases From Multiple Colorectal Cancers With Familial Adenomatous Polyposis. PMID: 25437589 |
Ref: Molecular diagnosis of intrahepatic cholangiocarcinoma. PMID: 25267595 Ref: Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma. PMID: 25608663 Ref: Transgenic mouse model expressing P53(R172H), luciferase, EGFP, and KRAS(G12D) in a single open reading frame for live imaging of tumor. PMID: 25623590 Ref: Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity. PMID: 25636086 Ref: Oncogenic KRAS promotes malignant brain tumors in zebrafish. PMID: 25644510 Ref: Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish. PMID: 25828472 Ref: Locoregional therapy and systemic cetuximab to treat colorectal liver metastases. PMID: 26090075 Ref: Targeted sequencing of cancer-associated genes in hepatocellular carcinoma using next generation sequencing. PMID: 26096009 Ref: Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. PMID: 26409325 Ref: Gene expression of IQGAPs and Ras families in an experimental mouse model for hepatocellular carcinoma: a mechanistic study of cancer progression. PMID: 26464624 Ref: An let-7 KRAS rs712 polymorphism increases hepatocellular carcinoma risk. PMID: 26535719 Ref: Prevalence of K-Ras mutations in hepatocellular carcinoma: A Turkish Oncology Group pilot study. PMID: 26807232 Ref: Roles of E-cadherin in Hepatocarcinogenesis PMID: 29787164 |
Ref: Stamping out RAF and MEK1/2 to inhibit the ERK1/2 pathway: an emerging threat to anticancer therapy. PMID: 26364606 Ref: Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model. PMID: 26471504 Ref: Conversion to resection of liver metastases from colorectal cancer with hepatic artery infusion of combined chemotherapy and systemic cetuximab in multicenter trial OPTILIV. PMID: 26578731 Ref: A Phase I Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Combination Therapy with Refametinib plus Sorafenib in Patients with Advanced Cancer. PMID: 26644411 Ref: Can KRAS and BRAF mutations limit the benefit of liver resection in metastatic colorectal cancer patients? A systematic review and meta-analysis. PMID: 26775732 Ref: Development of a conditional liver tumor model by mifepristone-inducible Cre recombination to control oncogenic kras V12 expression in transgenic zebrafish. PMID: 26790949 Ref: The impact of KRAS mutations on prognosis in surgically resected colorectal cancer patients with liver and lung metastases: a retrospective analysis. PMID: 26887348 Ref: MicroRNA-543 suppresses colorectal cancer growth and metastasis by targeting KRAS, MTA1 and HMGA2. PMID: 26968810 Ref: Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations. PMID: 27009864 Ref: The landscape of targeted therapies for cholangiocarcinoma: current status and emerging targets. PMID: 27102149 Ref: Molecular targets of Chinese herbs: a clinical study of hepatoma based on network pharmacology. PMID: 27143508 Ref: Conversion Chemotherapy for Technically Unresectable Colorectal Liver Metastases: A Retrospective, STROBE-Compliant, Single-Center Study Comparing Chemotherapy Alone and Combination Chemotherapy With Cetuximab or Bevacizumab. PMID: 27196492 Ref: IQGAP1 gene silencing induces apoptosis and decreases the invasive capacity of human hepatocellular carcinoma cells. PMID: 27488117 Ref: Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver. PMID: 27506299 Ref: A genetic database can be utilized to identify potential biomarkers for biphenotypic hepatocellular carcinoma-cholangiocarcinoma. PMID: 27563447 Ref: FOLFIRI plus cetuximab in patients with liver-limited or non-liver-limited RAS wild-type metastatic colorectal cancer: A retrospective subgroup analysis of the CRYSTAL study. PMID: 27575968 Ref: Early tumour response as a survival predictor in previously- treated patients receiving triplet hepatic artery infusion and intravenous cetuximab for unresectable liver metastases from wild-type KRAS colorectal cancer. PMID: 27768923 Ref: CXCR4-CXCL12-CXCR7, TLR2-TLR4, and PD-1/PD-L1 in colorectal cancer liver metastases from neoadjuvant-treated patients. PMID: 28123896 Ref: The significance of transarterial chemoembolization combined with systemic chemotherapy for patients with KRAS wild-type unresectable metachronous colorectal carcinoma with liver metastases. PMID: 28230018 |
Ref: Connecting cancer biology and clinical outcomes to imaging in KRAS mutant and wild-type colorectal cancer liver tumors following selective internal radiation therapy with yttrium-90. PMID: 27600383 Ref: Mutational landscape of combined hepatocellular carcinoma and cholangiocarcinoma, and its clinicopathological significance. PMID: 27634656 Ref: Mutant p53 Together with TGFbeta Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer. PMID: 27637888 Ref: The COMET Open-label Phase II Study of Neoadjuvant FOLFOX or XELOX Treatment Combined with Molecular Targeting Monoclonal Antibodies in Patients with Resectable Liver Metastasis of Colorectal Cancer. PMID: 27638675 Ref: Yttrium-90 radioembolization for colorectal cancer liver metastases in KRAS wild-type and mutant patients: Clinical and ccfDNA studies. PMID: 28004119 Ref: Males develop faster and more severe hepatocellular carcinoma than females in kras(V12) transgenic zebrafish. PMID: 28117409 Ref: Tumor-Associated Neutrophils and Macrophages Promote Gender Disparity in Hepatocellular Carcinoma in Zebrafish. PMID: 28202512 Ref: Transcriptomic analyses of RNA-binding proteins reveal eIF3c promotes cell proliferation in hepatocellular carcinoma. PMID: 28231410 Ref: Chemical inhibition reveals differential requirements of signaling pathways in kras(V12)- and Myc-induced liver tumors in transgenic zebrafish. PMID: 28378824 Ref: An investigation of the role of gene copy number variations in sorafenib sensitivity in metastatic hepatocellular carcinoma patients. PMID: 28382134 Ref: The identification of key genes and pathways in hepatocellular carcinoma by bioinformatics analysis of high-throughput data. PMID: 28432618 Ref: Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma. PMID: 28462385 Ref: Modeling the Iatrogenic Pancreatic Cancer Risk After Islet Autotransplantation in Mouse. PMID: 28510280 Ref: Activation of liver stromal cells is associated with male-biased liver tumor initiation in xmrk and Myc transgenic zebrafish. PMID: 28871112 Ref: The Oncopig Cancer Model: An Innovative Large Animal Translational Oncology Platform. PMID: 28879168 Ref: Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer. PMID: 28939741 Ref: A validated, transitional and translational porcine model of hepatocellular carcinoma. PMID: 28969016 Ref: Hepatoid Adenocarcinoma of the Stomach: A Challenging Diagnostic and Therapeutic Disease through a Case Report and Review of the Literature. PMID: 29034239 Ref: Establishing a colorectal cancer liver metastasis patient-derived tumor xenograft model for the evaluation of personalized chemotherapy. PMID: 29094026 Ref: Mucinous Cystic Neoplasms Lined by Abundant Mucinous Epithelium Frequently Involve KRAS Mutations and Malignant Progression. PMID: 29187496 |
Ref: Aminoacylase 3 Is a New Potential Marker and Therapeutic Target in Hepatocellular Carcinoma. PMID: 29290764 Ref: Loss of KRAS control as consequence of downregulated microRNA-622 in hepatocellular carcinoma and its potential therapeutic implication. PMID: 29353250 Ref: Primary Liver Cancers, Part 2: Progression Pathways and Carcinogenesis. PMID: 29353494 Ref: Combination of Kras activation and PTEN deletion contributes to murine hepatopancreatic ductal malignancy. PMID: 29452147 Ref: Mutant KRAS promotes liver metastasis of colorectal cancer, in part, by upregulating the MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR signaling pathway. PMID: 29559746 Ref: Molecular genomic landscapes of hepatobiliary cancer. PMID: 29573058 Ref: A novel zebrafish intestinal tumor model reveals a role for cyp7a1-dependent tumor-liver crosstalk in causing adverse effects on the host. PMID: 29592890 Ref: Activation of Hepatic Stellate Cells During Liver Carcinogenesis Requires Fibrinogen/Integrin alphavbeta5 in Zebrafish. PMID: 29649779 Ref: An EGFR ligand promotes EGFR-mutant but not KRAS-mutant lung cancer in vivo. PMID: 29662194 Ref: Study of promoter hypomethylation profiles of RAS oncogenes in hepatocellular carcinoma derived from hepatitis C virus genotype 3a in Pakistani population. PMID: 29742286 Ref: Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish. PMID: 29855567 Ref: Kras and Tp53 Mutations Cause Cholangiocyte- and Hepatocyte-Derived Cholangiocarcinoma. PMID: 29871934 Ref: CTGF Mediates Tumor-Stroma Interactions between Hepatoma Cells and Hepatic Stellate Cells to Accelerate HCC Progression. PMID: 29967264 Ref: Metformin Enhances Cisplatin-Induced Apoptosis and Prevents Resistance to Cisplatin in Co-mutated KRAS/LKB1 NSCLC. PMID: 30149143 Ref: Emergence of Intrahepatic Cholangiocarcinoma: How High-Throughput Technologies Expedite the Solutions for a Rare Cancer Type. PMID: 30158952 Ref: Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-Kras(G12D/+);Tp53(R172H/+) (KPC) mice, a genetically engineered model of pancreatic cancer. PMID: 30306263 Ref: Spatio-temporal tumor heterogeneity in metastatic CRC tumors: a mutational-based approach. PMID: 30344942 |