Primary Site >> Liver Cancer
Gene >> KLF6
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Ref: Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma. PMID: 15486921 Ref: [A candidate tumor suppressor gene mutated in primary hepatocellular carcinoma: kruppel-like factor 6]. PMID: 15598377 Ref: KLF6mRNA expression in primary hepatocellular carcinoma. PMID: 15791848 |
Ref: Absence of mutation in the putative tumor-suppressor gene KLF6 in colorectal cancers. PMID: 16044160 |
Ref: [Mutations of the tumor suppressor Kruppel-like factor 6 (KLF6) gene in hepatocellular carcinoma and its effect of growth suppression on human hepatocellular carcinoma cell line HepG2]. PMID: 16494780 Ref: Genetic and epigenetic alterations of the KLF6 gene in hepatocellular carcinoma. PMID: 16872311 Ref: Inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) by mutation or decreased expression in hepatocellular carcinomas. PMID: 16972326 Ref: Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma. PMID: 17341888 |
Ref: Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation. PMID: 17196295 Ref: In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma. PMID: 17297474 Ref: KLF6 transcription factor protects hepatocellular carcinoma-derived cells from apoptosis. PMID: 17347668 Ref: Loss of expression of Kruppel-like factor 6 in primary hepatocellular carcinoma and hepatoma cell lines. PMID: 17550140 |
Ref: Expression of the transcription factor Klf6 in cirrhosis, macronodules, and hepatocellular carcinoma. PMID: 18171345 Ref: Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis. PMID: 18280469 Ref: Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma. PMID: 18471523 Ref: [Effect of KLF6 and its splice variant KLF6V on proliferation and differentiation of human hepatocellular carcinoma HepG2 cells]. PMID: 18822210 |
Ref: Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene. PMID: 20116377 Ref: Frequent down-regulation and deletion of KLF6 in primary hepatocellular carcinoma. PMID: 20714872 Ref: The SV2 variant of KLF6 is down-regulated in hepatocellular carcinoma and displays anti-proliferative and pro-apoptotic functions. PMID: 20801538 Ref: Characterization of E2F3a function in HepG2 liver cancer cells. PMID: 20803551 |
Ref: Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation. PMID: 21563203 |
Ref: New candidate tumor-suppressor gene KLF6 and its splice variant KLF6 SV2 counterbalancing expression in primary hepatocarcinoma. PMID: 21940380 Ref: Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing. PMID: 22535637 Ref: MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. PMID: 22820290 Ref: Hepatocyte growth factor enhances alternative splicing of the Kruppel-like factor 6 (KLF6) tumor suppressor to promote growth through SRSF1. PMID: 22859706 |
Ref: GSK3beta phosphorylation of the KLF6 tumor suppressor promotes its transactivation of p21. PMID: 23085750 Ref: The Role of the 3' Untranslated Region in the Post-Transcriptional Regulation of KLF6 Gene Expression in Hepatocellular Carcinoma. PMID: 24378751 |
Ref: Identification of miRNAs that specifically target tumor suppressive KLF6-FL rather than oncogenic KLF6-SV1 isoform. PMID: 24921656 |
Ref: Kruppel-like factors in hepatocellular carcinoma. PMID: 25652467 |
Ref: A novel KLF6-Rho GTPase axis regulates hepatocellular carcinoma cell migration and dissemination. PMID: 26876204 Ref: Interaction of KLF6 and Sp1 regulates basigin-2 expression mediated proliferation, invasion and metastasis in hepatocellular carcinoma. PMID: 27057625 Ref: Kruppel-like factor 6 suppresses growth and invasion of hepatocellular carcinoma cells in vitro and in vivo. PMID: 27510817 |
Ref: Berberine regulates the protein expression of multiple tumorigenesis-related genes in hepatocellular carcinoma cell lines. PMID: 28572744 Ref: Platelet releasates promote the proliferation of hepatocellular carcinoma cells by suppressing the expression of KLF6. PMID: 28638139 Ref: Kruppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury. PMID: 28808340 |