Primary Site >> Colorectal Cancer
Gene >> KLF5
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Ref: Intestinal tumor progression is associated with altered function of KLF5. PMID: 14726538 Ref: All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5. PMID: 15581624 |
Ref: Transcriptome analysis of human colon Caco-2 cells exposed to sulforaphane. PMID: 16046710 |
Ref: Identification of differentially expressed genes involved in the formation of multicellular tumor spheroids by HT-29 colon carcinoma cells. PMID: 17164780 Ref: Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Kruppel-like factor 5. PMID: 17430902 |
Ref: Kruppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis. PMID: 18054006 Ref: The Pathobiology of Kruppel-like Factors in Colorectal Cancer. PMID: 18504508 Ref: SUMOylation regulates nuclear localization of Kruppel-like factor 5. PMID: 18782761 |
Ref: Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening. PMID: 19240162 Ref: The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer. PMID: 19328876 Ref: Haploinsufficiency of Kruppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine. PMID: 19435907 Ref: KLF4-dependent, PPARgamma-induced expression of GPA33 in colon cancer cell lines. PMID: 19551868 Ref: Up-regulation of Kruppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha. PMID: 19671674 |
Ref: Kruppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations. PMID: 20298593 Ref: The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine. PMID: 20724530 Ref: ML264: An Antitumor Agent that Potently and Selectively Inhibits Kruppel-like Factor Five (KLF5) Expression: A Probe for Studying Colon Cancer Development and Progression PMID: 23762940 |
Ref: Identification of small-molecule inhibitors of the colorectal cancer oncogene Kruppel-like factor 5 expression by ultrahigh-throughput screening. PMID: 21885866 |
Ref: Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression. PMID: 23128394 Ref: Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/beta-catenin pathway in colorectal cancer. PMID: 23319804 Ref: Regulation of hypoxia-inducible factor 1alpha (HIF-1alpha) by lysophosphatidic acid is dependent on interplay between p53 and Kruppel-like factor 5. PMID: 23880760 |
Ref: Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines. PMID: 23676439 Ref: A colon cancer-derived mutant of Kruppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3beta (GSK3beta) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7alpha (FBW7alpha). PMID: 24398687 Ref: Inducible intestine-specific deletion of Kruppel-like factor 5 is characterized by a regenerative response in adult mouse colon. PMID: 24440658 Ref: The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner. PMID: 25037223 |
Ref: Kruppel-like factor 5 incorporates into the beta-catenin/TCF complex in response to LPA in colon cancer cells. PMID: 25683913 Ref: The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner. PMID: 26092983 Ref: Two novel variants on 13q22.1 are associated with risk of esophageal squamous cell carcinoma. PMID: 26315552 |
Ref: DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis. PMID: 25772234 Ref: ML264, A Novel Small-Molecule Compound That Potently Inhibits Growth of Colorectal Cancer. PMID: 26621868 Ref: Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma. PMID: 27149842 |
Ref: YD277 Suppresses Triple-Negative Breast Cancer Partially Through Activating the Endoplasmic Reticulum Stress Pathway. PMID: 28740556 Ref: Ascl2 activation by YAP1/KLF5 ensures the self-renewability of colon cancer progenitor cells. PMID: 29312609 |
Ref: Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor. PMID: 28963353 Ref: GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12. PMID: 29471430 Ref: KLF5 mediates the hyper-proliferative phenotype of the intestinal epithelium in mice with intestine-specific endogenous K-Ras(G12D) expression. PMID: 29736317 Ref: Advanced Glycation End Products Increase MDM2 Expression via Transcription Factor KLF5. PMID: 30271790 |