Primary Site >> Colorectal Cancer
Gene >> KLF4
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Ref: Sequence of the 5'-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells. PMID: 10840001 Ref: Up-regulation of gut-enriched kruppel-like factor by interferon-gamma in human colon carcinoma cells. PMID: 10899312 Ref: Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif. PMID: 10908361 Ref: Increase of GKLF messenger RNA and protein expression during progression of breast cancer. PMID: 11103818 |
Ref: A nucleus-localization-deficient mutant serves as a dominant-negative inhibitor of gut-enriched Kruppel-like factor function. PMID: 11322789 Ref: Kruppel-like factor 4 (gut-enriched Kruppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle. PMID: 11390382 Ref: Expression of the gut-enriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. PMID: 11521200 |
Ref: Gut-enriched Kruppel-like factor represses ornithine decarboxylase gene expression and functions as checkpoint regulator in colonic cancer cells. PMID: 12297499 Ref: Gut-enriched Kruppel-like factor regulates colonic cell growth through APC/beta-catenin pathway. PMID: 12387883 Ref: STAT1 is required for IFN-gamma-mediated gut-enriched Kruppel-like factor expression. PMID: 12441126 |
Ref: Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. PMID: 12427745 Ref: Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. PMID: 12776194 Ref: Transcriptional regulation of A33 antigen expression by gut-enriched Kruppel-like factor. PMID: 12853980 |
Ref: Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor. PMID: 12919939 Ref: Requirement of Kruppel-like factor 4 in preventing entry into mitosis following DNA damage. PMID: 14627709 Ref: Identification of Kruppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. PMID: 14724568 Ref: The Kruppel-like KLF4 transcription factor, a novel regulator of urokinase receptor expression, drives synthesis of this binding site in colonic crypt luminal surface epithelial cells. PMID: 15031282 Ref: Kruppel-like factor 4 is transactivated by butyrate in colon cancer cells. PMID: 15051827 |
Ref: Hic-5 regulates an epithelial program mediated by PPARgamma. PMID: 15687259 Ref: Kruppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage. PMID: 15806166 Ref: Transcriptome analysis of human colon Caco-2 cells exposed to sulforaphane. PMID: 16046710 Ref: 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal tra PMID: 16077033 |
Ref: Emerging role of KLF4 in human gastrointestinal cancer. PMID: 16219632 Ref: Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. PMID: 16507986 Ref: Altered expression of the KLF4 in colorectal cancers. PMID: 16814484 |
Ref: Kruppel-like factor 4 exhibits antiapoptotic activity following gamma-radiation-induced DNA damage. PMID: 17016435 Ref: Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells. PMID: 17513608 Ref: Haploinsufficiency of Kruppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. PMID: 17671182 Ref: 2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells. PMID: 17724373 Ref: Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. PMID: 17908689 |
Ref: Dynamic down-regulation of Kruppel-like factor 4 in colorectal adenoma-carcinoma sequence. PMID: 18264726 Ref: Nuclear Kruppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis. PMID: 18376139 Ref: The Pathobiology of Kruppel-like Factors in Colorectal Cancer. PMID: 18504508 Ref: 5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells. PMID: 18645021 Ref: KLF4 regulation in intestinal epithelial cell maturation. PMID: 18977346 Ref: Notch inhibits expression of the Kruppel-like factor 4 tumor suppressor in the intestinal epithelium. PMID: 19074836 |
Ref: KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract. PMID: 19109406 Ref: Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1). PMID: 19116884 Ref: Mouse embryonic fibroblasts null for the Kruppel-like factor 4 gene are genetically unstable. PMID: 19137014 Ref: The symplekin/ZONAB complex inhibits intestinal cell differentiation by the repression of AML1/Runx1. PMID: 19328795 Ref: Kruppel-like factor 4, a "pluripotency transcription factor" highly expressed in male postmeiotic germ cells, is dispensable for spermatogenesis in the mouse. PMID: 19539755 Ref: KLF4-dependent, PPARgamma-induced expression of GPA33 in colon cancer cell lines. PMID: 19551868 Ref: Comprehensive analysis of the clinical significance of inducing pluripotent stemness-related gene expression in colorectal cancer cells. PMID: 19554373 Ref: A novel small molecule with potent anticancer activity inhibits cell growth by modulating intracellular labile zinc homeostasis. PMID: 19755513 Ref: The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. PMID: 19935649 |
Ref: Peroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells. PMID: 19823826 Ref: KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin. PMID: 19901072 Ref: Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction. PMID: 20068171 Ref: MCC-555-induced NAG-1 expression is mediated in part by KLF4. PMID: 20385121 Ref: Expression of the tumor suppressor Kruppel-like factor 4 as a prognostic predictor for colon cancer. PMID: 20699379 |
Ref: Resveratrol-induced apoptosis is mediated by early growth response-1, Kruppel-like factor 4, and activating transcription factor 3. PMID: 21205742 Ref: LIN28B promotes colon cancer progression and metastasis. PMID: 21512136 Ref: KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis. PMID: 21531817 Ref: Acetylbritannilactone suppresses growth via upregulation of kruppel-like transcription factor 4 expression in HT-29 colorectal cancer cells. PMID: 21811764 Ref: KLF4 Expression Correlates with the Degree of Differentiation in Colorectal Cancer. PMID: 21814594 |
Ref: Regulation of the potential marker for intestinal cells, Bmi1, by beta-catenin and the zinc finger protein KLF4: implications for colon cancer. PMID: 22170051 Ref: Induced pluripotent stem cell-related genes influence biological behavior and 5-fluorouracil sensitivity of colorectal cancer cells. PMID: 22205615 Ref: Regulation of KLF4 turnover reveals an unexpected tissue-specific role of pVHL in tumorigenesis. PMID: 22284679 Ref: Hypoxia and TP53 deficiency for induced pluripotent stem cell-like properties in gastrointestinal cancer. PMID: 22293932 Ref: Kruppel-like factor 4 regulates intestinal epithelial cell morphology and polarity. PMID: 22384261 Ref: Novel insight into KLF4 proteolytic regulation in estrogen receptor signaling and breast carcinogenesis. PMID: 22389506 Ref: Dicer 1, ribonuclease type III modulates a reprogramming effect in colorectal cancer cells. PMID: 22446887 Ref: miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4. PMID: 22593189 Ref: Identifying microRNA-mRNA regulatory network in colorectal cancer by a combination of expression profile and bioinformatics analysis. PMID: 22703586 Ref: A role for low-abundance miRNAs in colon cancer: the miR-206/Kruppel-like factor 4 (KLF4) axis. PMID: 23006636 Ref: The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment. PMID: 23173124 |
Ref: Oncogenic Wnt/beta-catenin signalling pathways in the cancer-resistant epididymis have implications for cancer research. PMID: 23155044 Ref: CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARgamma signaling. PMID: 23202735 Ref: Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo. PMID: 23418447 Ref: Kruppel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cells. PMID: 23418515 Ref: Excellence in cell signaling research recognized with major new award. PMID: 23497077 Ref: Deregulation of the CDX2-KLF4 axis in acute myeloid leukemia and colon cancer. PMID: 23563447 Ref: Suppression of colon carcinogenesis by targeting Notch signaling. PMID: 23729655 Ref: Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen species. PMID: 23916687 Ref: Kruppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts. PMID: 23919723 Ref: Epigenetic regulation of pluripotent genes mediates stem cell features in human hepatocellular carcinoma and cancer cell lines. PMID: 24023739 Ref: Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice. PMID: 24204315 |
Ref: MicroRNA-29a promotes colorectal cancer metastasis by regulating matrix metalloproteinase 2 and E-cadherin via KLF4. PMID: 24281002 Ref: Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding. PMID: 24962990 Ref: Induction of cancer stem cell properties in colon cancer cells by defined factors. PMID: 25006808 Ref: High KLF4 level in normal tissue predicts poor survival in colorectal cancer patients. PMID: 25060774 |
Ref: A Cancer Reprogramming Method Using MicroRNAs as a Novel Therapeutic Approach against Colon Cancer: Research for Reprogramming of Cancer Cells by MicroRNAs. PMID: 25384704 Ref: The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to target colon cancer stem-like cells. PMID: 25625841 Ref: MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells. PMID: 25970424 Ref: Identification of a distinct population of CD133(+)CXCR4(+) cancer stem cells in ovarian cancer. PMID: 26020117 Ref: Phase 1 study of APTO-253 HCl, an inducer of KLF4, in patients with advanced or metastatic solid tumors. PMID: 26268924 Ref: Verification of ALDH Activity as a Biomarker in Colon Cancer Stem Cells-Derived HT-29 Cell Line. PMID: 26634106 |
Ref: In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases. PMID: 26031752 Ref: MiR-375 targets KLF4 and impacts the proliferation of colorectal carcinoma. PMID: 26224477 Ref: KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis. PMID: 26839262 Ref: Integrated genomic profiling identifies microRNA-92a regulation of IQGAP2 in locally advanced rectal cancer. PMID: 26865277 Ref: Labeling of target mRNAs using a photo-reactive microRNA probe. PMID: 27117176 Ref: MicroRNA-92a Promotes Colorectal Cancer Cell Growth and Migration by Inhibiting KLF4. PMID: 27131314 Ref: MiR-205 and MiR-373 Are Associated with Aggressive Human Mucinous Colorectal Cancer. PMID: 27271572 Ref: MFHAS1 promotes colorectal cancer progress by regulating polarization of tumor-associated macrophages via STAT6 signaling pathway. PMID: 27783989 Ref: MicroRNA-92a Promotes Colorectal Cancer Cell Growth and Migration by Inhibiting KLF4. PMID: 27931284 |
Ref: Delta-like 4/Notch signaling promotes Apc (Min/+) tumor initiation through angiogenic and non-angiogenic related mechanisms. PMID: 28086833 Ref: Tumor-suppressive role of Kruppel-like factor 4 (KLF-4) in colorectal cancer. PMID: 28218782 Ref: A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat. PMID: 28289824 Ref: Next-generation sequencing traces human induced pluripotent stem cell lines clonally generated from heterogeneous cancer tissue. PMID: 28596815 Ref: KLF4 inhibits colorectal cancer cell proliferation dependent on NDRG2 signaling. PMID: 28656310 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: The Tissue-Reconstructing Ability of Colon CSCs Is Enhanced by FK506 and Suppressed by GSK3 Inhibition. PMID: 28710230 Ref: Kruppel-like factor 4 acts as a potential therapeutic target of Sijunzi decoction for treatment of colorectal cancer. PMID: 28752861 Ref: Involvement of CRF2 signaling in enterocyte differentiation. PMID: 28811708 Ref: miR-543 promotes colorectal cancer proliferation and metastasis by targeting KLF4. PMID: 28938633 Ref: Identification of Key Genes in Colorectal Cancer Regulated by miR-34a. PMID: 29197895 Ref: MiR-92a promotes stem cell-like properties by activating Wnt/beta-catenin signaling in colorectal cancer. PMID: 29254202 Ref: Commensal-infected macrophages induce dedifferentiation and reprogramming of epithelial cells during colorectal carcinogenesis. PMID: 29254234 Ref: Characterization of Cancer Stem Cells in Colon Adenocarcinoma Metastasis to the Liver. PMID: 29404335 |
Ref: Activation of KLF4 expression by small activating RNA promotes migration and invasion in colorectal epithelial cells. PMID: 29274293 Ref: Kruppel-like factor 4 mediates cellular migration and invasion by altering RhoA activity. PMID: 29498307 Ref: Extracted metabolite from Streptomyces Levis ABRIINW111 altered the gene expression in colon cancer. PMID: 29564063 Ref: Lgr5+CD44+EpCAM+ Strictly Defines Cancer Stem Cells in Human Colorectal Cancer. PMID: 29627827 Ref: KLF4 Mediates the Effect of 5-ASA on the beta-Catenin Pathway in Colon Cancer Cells. PMID: 29794245 Ref: Dietary Red Raspberry Reduces Colorectal Inflammation and Carcinogenic Risk in Mice with Dextran Sulfate Sodium-Induced Colitis. PMID: 29897487 Ref: Increased genetic instability and accelerated progression of colitis-associated colorectal cancer through intestinal epithelium-specific deletion of Klf4. PMID: 30108164 Ref: MiR-92a promotes tumorigenesis of colorectal cancer, a transcriptomic and functional based study. PMID: 30119209 Ref: Cell biological profiling of reprogrammed cancer stem cell-like colon cancer cells maintained in culture. PMID: 30284085 Ref: Analysis of cell proliferation and tissue remodelling uncovers a KLF4 activity score associated with poor prognosis in colorectal cancer. PMID: 30287917 |