Primary Site >> Colorectal Cancer
Gene >> KDM1A
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Ref: Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. PMID: 17463086 |
Ref: Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes. PMID: 19934284 |
Ref: Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. PMID: 20333681 |
Ref: Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes. PMID: 22132744 Ref: DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes. PMID: 22278882 |
Ref: Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner. PMID: 23072722 Ref: Positive expression of LSD1 and negative expression of E-cadherin correlate with metastasis and poor prognosis of colon cancer. PMID: 23314859 Ref: MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A. PMID: 23400681 Ref: Functional and cancer genomics of ASXL family members. PMID: 23736028 Ref: LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer. PMID: 23900215 Ref: Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/beta-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected]. PMID: 23922913 Ref: High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors. PMID: 24237195 Ref: alpha-Catenin interacts with APC to regulate beta-catenin proteolysis and transcriptional repression of Wnt target genes. PMID: 24240237 |
Ref: Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. PMID: 24325601 Ref: Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3. PMID: 24691920 Ref: Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1. PMID: 25043185 |
Ref: CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression. PMID: 25060070 Ref: SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. PMID: 25277775 Ref: A Protein Interaction between beta-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells. PMID: 25753001 |
Ref: Long noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression. PMID: 27246976 Ref: Long noncoding RNA HOXA-AS2 represses P21 and KLF2 expression transcription by binding with EZH2, LSD1 in colorectal cancer. PMID: 28112720 Ref: Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells. PMID: 28121627 Ref: [The influence and mechanisms of lysine-specific demethylase 1 (LSD1) on invasion and metastasis of colon cancer cells]. PMID: 28316154 Ref: Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex-dependent fashion. PMID: 28717007 Ref: The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN. PMID: 28779166 |
Ref: Knockdown of pseudogene derived from lncRNA DUXAP10 inhibits cell proliferation, migration, invasion, and promotes apoptosis in pancreatic cancer. PMID: 29286182 Ref: Lysine-specific demethylase 1 activation by vitamin B2 attenuates efficacy of apatinib for proliferation and migration of gastric cancer cell MGC-803. PMID: 29384217 Ref: Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers. PMID: 29384474 Ref: New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells. PMID: 29439916 Ref: Design, synthesis and biological activity of 4-(4-benzyloxy)phenoxypiperidines as selective and reversible LSD1 inhibitors. PMID: 29524666 Ref: Prognostic value of histone marks H3K27me3 and H3K9me3 and modifying enzymes EZH2, SETDB1 and LSD-1 in colorectal cancer. PMID: 30105513 Ref: Design, synthesis, and biological evaluation of a conjugate of 5-fluorouracil and an LSD1 inhibitor. PMID: 30369513 |