Primary Site >> Pancreatic Cancer
Gene >> JAK1
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Ref: LLL12 inhibits endogenous and exogenous interleukin-6-induced STAT3 phosphorylation in human pancreatic cancer cells. PMID: 21737619 |
Ref: Role of janus kinase/signal transducers and activators of transcription in the pathogenesis of pancreatitis and pancreatic cancer. PMID: 23170143 |
Ref: Molecular pathways: Jak/STAT pathway: mutations, inhibitors, and resistance. PMID: 23406773 |
Ref: Whole-exome sequencing of pancreatic neoplasms with acinar differentiation. PMID: 24293293 |
Ref: TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis. PMID: 25762644 Ref: Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1. PMID: 26331681 Ref: Randomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed. PMID: 26351344 |
Ref: Angiogenic gene signature in human pancreatic cancer correlates with TGF-beta and inflammatory transcriptomes. PMID: 26586478 Ref: Blockage of STAT3 Signaling Pathway by Morusin Induces Apoptosis and Inhibits Invasion in Human Pancreatic Tumor Cells. PMID: 26646273 Ref: Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells. PMID: 26719042 Ref: Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus. PMID: 27533247 |
Ref: Potent EMT and CSC Phenotypes Are Induced By Oncostatin-M in Pancreatic Cancer. PMID: 28053127 Ref: Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo. PMID: 28496202 Ref: Ruxolitinib and Polycation Combination Treatment Overcomes Multiple Mechanisms of Resistance of Pancreatic Cancer Cells to Oncolytic Vesicular Stomatitis Virus. PMID: 28566376 Ref: MicroRNA-448 suppresses metastasis of pancreatic ductal adenocarcinoma through targeting JAK1/STAT3 pathway. PMID: 28677798 Ref: Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors. PMID: 29259370 |
Ref: Ruxolitinib + capecitabine in advanced/metastatic pancreatic cancer after disease progression/intolerance to first-line therapy: JANUS 1 and 2 randomized phase III studies. PMID: 29508247 Ref: Blocking IL-6/GP130 signaling inhibits cell viability/proliferation, glycolysis, and colony forming activity in human pancreatic cancer cells. PMID: 29714141 Ref: A Phase Ib study of ruxolitinib + gemcitabine +/- nab-paclitaxel in patients with advanced solid tumors. PMID: 29750040 Ref: Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma. PMID: 30105668 Ref: A Phase Ib/II Study of the JAK1 Inhibitor, Itacitinib, plus nab-Paclitaxel and Gemcitabine in Advanced Solid Tumors. PMID: 30115734 |