Primary Site >> Colorectal Cancer
Gene >> JAK1
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Ref: Receptors for interleukin (IL)-4 do not associate with the common gamma chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells. PMID: 8530527 |
Ref: IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling. PMID: 8609418 |
Ref: Comparative tyrosine-kinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa. PMID: 10521789 |
Ref: SHP-1 suppresses cancer cell growth by promoting degradation of JAK kinases. PMID: 14624462 |
Ref: Requirement of histone deacetylase activity for signaling by STAT1. PMID: 15123634 |
Ref: Absence of tyrosine kinase mutations in Japanese colorectal cancer patients. PMID: 17016444 |
Ref: Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. PMID: 18320073 |
Ref: Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression. PMID: 19561401 |
Ref: JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. PMID: 22121102 Ref: Cancer upregulated gene 2, a novel oncogene, enhances migration and drug resistance of colon cancer cells via STAT1 activation. PMID: 23917355 Ref: INCB018424 induces apoptotic cell death through the suppression of pJAK1 in human colon cancer cells. PMID: 24050550 Ref: RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients. PMID: 24098947 |
Ref: INCB018424 induces apoptotic cell death through the suppression of pJAK1 in human colon cancer cells. PMID: 24195509 Ref: ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer. PMID: 24931611 |
Ref: Effect of Smad3/4 on chemotherapeutic drug sensitivity in colorectal cancer cells. PMID: 25370208 Ref: The Tumor Suppressive Effects of HPP1 Are Mediated Through JAK-STAT-Interferon Signaling Pathways. PMID: 26061044 Ref: Prognostic and Predictive Biomarkers in Colorectal Cancer. From the Preclinical Setting to Clinical Practice. PMID: 26452385 |
Ref: Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis. PMID: 27546461 |
Ref: The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network. PMID: 27893714 Ref: Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations. PMID: 27903500 Ref: Interleukin-4 and interleukin-13 increase NADPH oxidase 1-related proliferation of human colon cancer cells. PMID: 28498822 Ref: Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1. PMID: 28539123 Ref: Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages. PMID: 29088814 |
Ref: Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers. PMID: 29641532 Ref: MiR-199a-5p Inhibits the Growth and Metastasis of Colorectal Cancer Cells by Targeting ROCK1. PMID: 29807462 Ref: Randomized, double-blind, phase two study of ruxolitinib plus regorafenib in patients with relapsed/refractory metastatic colorectal cancer. PMID: 30123970 |