Primary Site >> Colorectal Cancer
Gene >> IRS2
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Ref: Aspirin, NSAIDs, and colorectal cancer: possible involvement in an insulin-related pathway. PMID: 15066917 Ref: Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer. PMID: 15247132 |
Ref: Energy balance, insulin-related genes and risk of colon and rectal cancer. PMID: 15688407 |
Ref: Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer. PMID: 16448675 Ref: PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States). PMID: 16489531 |
Ref: Insulin resistance-related genes and advanced left-sided colorectal adenoma. PMID: 17416760 Ref: Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect. PMID: 17914103 |
Ref: Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. PMID: 18059035 |
Ref: Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer. PMID: 19671761 |
Ref: Cytosolic malic enzyme 1 (ME1) mediates high fat diet-induced adiposity, endocrine profile, and gastrointestinal tract proliferation-associated biomarkers in male mice. PMID: 23056418 |
Ref: IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer. PMID: 23594372 Ref: Novel insulin receptor substrate 1 and 2 variants in breast and colorectal cancer. PMID: 23877285 Ref: Molecular predictors of sensitivity to the insulin-like growth factor 1 receptor inhibitor Figitumumab (CP-751,871). PMID: 24107449 Ref: Is there an association between variants in candidate insulin pathway genes IGF-I, IGFBP-3, INSR, and IRS2 and risk of colorectal cancer in the Iranian population? PMID: 24175768 |
Ref: Lack of association between insulin receptor substrate2 rs1805097 polymorphism and the risk of colorectal and breast cancer: a meta-analysis. PMID: 24497996 Ref: IRS-2 G1057D polymorphism in Turkish patients with colorectal cancer. PMID: 25061488 Ref: MHC-restricted phosphopeptides from insulin receptor substrate-2 and CDC25b offer broad-based immunotherapeutic agents for cancer. PMID: 25297629 |
Ref: IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines. PMID: 25527633 Ref: An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women. PMID: 25557790 Ref: Role of microRNA 30a targeting insulin receptor substrate 2 in colorectal tumorigenesis. PMID: 25582198 Ref: Evaluating patient-derived colorectal cancer xenografts as preclinical models by comparison with patient clinical data. PMID: 25712343 Ref: Frameshift mutations in mammalian target of rapamycin pathway genes and their regional heterogeneity in sporadic colorectal cancers. PMID: 25776026 Ref: The genomic landscape of response to EGFR blockade in colorectal cancer. PMID: 26416732 |
Ref: BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells. PMID: 27351224 |
Ref: IRS-2 rs1805097 polymorphism is associated with the decreased risk of colorectal cancer. PMID: 28212577 Ref: Dietary glycemic and insulin scores and colorectal cancer survival by tumor molecular biomarkers. PMID: 28268248 |