Primary Site >> Pancreatic Cancer
Gene >> IRS1
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Increased expression of insulin receptor substrate-1 in human pancreatic cancer. PMID: 8607861 Ref: Insulin-like growth factor II activates mitogenic signaling in pancreatic cancer cells via IRS-1. PMID: 21541539 |
Ref: Interleukin-4 enhances proliferation of human pancreatic cancer cells: evidence for autocrine and paracrine actions. PMID: 15714203 Ref: Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells. PMID: 16230374 |
Ref: RAV12 accelerates the desensitization of Akt/PKB pathway of insulin-like growth factor I receptor signaling in COLO205. PMID: 17875727 |
Ref: Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis. PMID: 18445520 |
Ref: Insulin receptor substrate-2 mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase Cdelta. PMID: 19190347 Ref: 2-Methoxyestradiol mediated signaling network in pancreatic cancer. PMID: 19273191 |
Ref: Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer. PMID: 20416304 Ref: Nitric oxide inhibits the proliferation and invasion of pancreatic cancer cells through degradation of insulin receptor substrate-1 protein. PMID: 20663861 |
Ref: Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer. PMID: 21852217 Ref: Molecular profiling of pancreatic neuroendocrine tumors in sporadic and Von Hippel-Lindau patients. PMID: 22461457 |
Ref: Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells. PMID: 23663483 |
Ref: The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT. PMID: 24936056 |
Ref: A genome-wide investigation of microRNA expression identifies biologically-meaningful microRNAs that distinguish between high-risk and low-risk intraductal papillary mucinous neoplasms of the pancreas. PMID: 25607660 Ref: Human pancreatic cancer stem cells are sensitive to dual inhibition of IGF-IR and ErbB receptors. PMID: 25886138 |
Ref: Identification of key regulators of pancreatic cancer progression through multidimensional systems-level analysis. PMID: 27137215 |
Ref: Long non-coding RNA CRNDE sponges miR-384 to promote proliferation and metastasis of pancreatic cancer cells through upregulating IRS1. PMID: 28940804 |