Primary Site >> Colorectal Cancer
Gene >> IL2RA
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Characterization of activated lymphocytes in colon cancer. PMID: 2783402 |
Ref: Proliferation, interleukin-2 production and receptor expression in peripheral blood mononuclear cells from colorectal cancer patients. PMID: 1974593 Ref: Granulocyte-monocyte colony-stimulating-factor augments the interleukin-2-induced cytotoxic activity of human lymphocytes in the absence and presence of mouse or chimeric monoclonal antibodies (mAb 17-1A). PMID: 2199042 |
Ref: Immunological effects of levamisole in vitro. PMID: 1790137 Ref: Factors influencing the establishment of tumour-infiltrating lymphocyte cultures from human breast carcinoma and colon carcinoma tissue. PMID: 1827279 Ref: Biological monitoring of low-dose interleukin 2 in humans: soluble interleukin 2 receptors, cytokines, and cell surface phenotypes. PMID: 1933892 Ref: Biological and clinical effects of intravenous tumor necrosis factor-alpha administered three times weekly. PMID: 1998956 |
Ref: Establishment of cytotoxic CD4+ T cell clones from cancer patients treated by local immunotherapy. PMID: 1363274 Ref: Mononuclear cells in normal colon and colonic carcinoma express the same T cell activation markers. PMID: 1392524 Ref: Perioperative immunotherapy with recombinant interleukin 2 in patients undergoing surgery for colorectal cancer. PMID: 1394200 Ref: Immunopathological changes in the skin following recombinant interleukin-2 treatment. PMID: 1517903 Ref: IL-2 production by intestinal lamina propria cells in normal inflamed and cancer-bearing colons. PMID: 1563100 |
Ref: Low-dose interleukin-2 in combination with interferon-alpha effectively modulates biological response in vivo. PMID: 7683166 Ref: Effects of a preoperative course of interleukin-2 on surgical and immunobiological variables in patients with colorectal cancer: a phase 2 study. PMID: 8095806 Ref: Short-duration in vitro interleukin-2-activated mononuclear cells for advanced cancer. A Hong Kong biotherapy pilot study trial. PMID: 8387882 Ref: Peri-operative modulation of cellular immunity in patients with colorectal cancer. PMID: 8403515 Ref: The expression and biological activity of IL-2 receptor on a human pancreas cancer cell line. PMID: 8507543 Ref: Inhibition of proliferation, activation and function of human natural-killer-cells in-vitro by secreted products of lovo, a colorectal-cancer cell-line. PMID: 21573430 |
Ref: Alteration in lymphocyte phenotype associated with administration of adjuvant levamisole and 5-fluorouracil. PMID: 7515770 Ref: Binding of natural human IgM auto-antibodies to human tumor cell lines and stimulated normal T lymphocytes. PMID: 7912225 Ref: Phenotypical and functional characteristics of tumor-infiltrating lymphocytes from colon carcinomas stimulated with rIL-2 and rIL-4 in vitro: comparison with lymphocytes of the normal colon mucosa and the peripheral blood. PMID: 8074499 Ref: Functional role of IL-2 receptors on tumour-infiltrating lymphocytes. PMID: 8198969 |
Ref: Colorectal cell line suppression of lymphokine activated killer cell generation is reversed by suramin. PMID: 7540893 Ref: Morphological and functional characteristics of tumor-infiltrating lymphocytes from human colorectal cancers after stimulation with rIL-2. PMID: 7649213 Ref: Modulation of the cytokine and acute-phase response to major surgery by recombinant interleukin-2. PMID: 7881967 Ref: Sequential biochemotherapy for metastatic colorectal cancer using fluorouracil, folinic acid, thymopentin and interleukin-2: clinical and immunological effects. PMID: 8750154 |
Ref: Necessity of biotherapeutic treatments inducing TH1 cell functions in colorectal cancer. PMID: 10851498 Ref: Immunological directives for biotherapy improvement in the treatment of colorectal cancer. PMID: 10851527 |
Ref: Modulations of the effector function and cytokine production of human lymphocytes by secreted factors derived from colorectal-carcinoma cells. PMID: 9212235 Ref: Expression of CD44, ICAM-1 and N-CAM in colorectal cancer. Correlation with the tumor stage and the phenotypical characteristics of tumor-infiltrating lymphocytes. PMID: 9252653 Ref: Interleukin-2-activated killer cell activity in colorectal tumor patients: evaluation of in vitro effects by prothymosin alpha1. PMID: 9292704 Ref: Modulation of immune response by blood transfusion: evidence for a differential effect of allogeneic and autologous blood in colorectal cancer surgery. PMID: 9421852 Ref: Construction and biological activity of a recombinant bispecific single-chain antibody designed for therapy of minimal residual colorectal cancer. PMID: 9435872 Ref: Preclinical studies with prothymosin alpha1 on mononuclear cells from tumor patients. PMID: 9637344 |
Ref: Interleukin 2 restores CD3-zeta chain expression but fails to generate tumour-specific lytic activity in tumour-infiltrating lymphocytes derived from human colorectal hepatic metastases. PMID: 9569042 Ref: Introduction of adhesive and costimulatory immune functions into tumor cells by infection with Newcastle Disease Virus. PMID: 9824618 |
Ref: Local expression of cytokines in human colorectal carcinoma: evidence of specific interleukin-6 gene expression. PMID: 9924696 Ref: FasL is more frequently expressed in liver metastases of colorectal cancer than in matched primary carcinomas. PMID: 10098769 Ref: Significance of pre-treatment immunological parameters in colorectal cancer patients with unresectable metastases to the liver. PMID: 10228796 Ref: Immunohistochemical analysis of inflammation in primary sclerosing cholangitis. PMID: 10445798 Ref: Increased activation of lymphocytes infiltrating primary colorectal cancers following immunisation with the anti-idiotypic monoclonal antibody 105AD7. PMID: 10486371 Ref: Influence of peri-operative immunotherapy on serum cytokines and soluble cytokine receptors in patients undergoing surgery for colorectal cancer. PMID: 23577850 |
Ref: Protective immunity against human carcinoembryonic antigen (CEA) induced by an oral DNA vaccine in CEA-transgenic mice. PMID: 11300483 Ref: A dual-function DNA vaccine encoding carcinoembryonic antigen and CD40 ligand trimer induces T cell-mediated protective immunity against colon cancer in carcinoembryonic antigen-transgenic mice. PMID: 11591784 |
Ref: The presence of interleukin-2 receptor alpha in the serum of colorectal cancer patients is unlikely to result only from T cell up-regulation. PMID: 11845260 Ref: Modulation of innate immunological factors by STEALTH liposome-encapsulated tumor necrosis factor-alpha in a colon tumor xenograft model. PMID: 12014650 Ref: Inhibition of cytolytic T lymphocyte proliferation by autologous CD4+/CD25+ regulatory T cells in a colorectal carcinoma patient is mediated by transforming growth factor-beta. PMID: 12234995 Ref: Serum soluble interleukin-2 receptor (IL-2R) and immunohistochemical staining of IL-2R/Tac antigen in colorectal cancer. PMID: 12402066 Ref: Helicobacter pylori organisms induce expression of activation and apoptotic surface markers on human lymphocytes and AGS cells: a cytofluorimetric evaluation. PMID: 12510791 Ref: Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens. PMID: 12555672 |
Ref: CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice. PMID: 12547727 Ref: Murine dendritic cells pulsed with an anti-idiotype antibody induce antigen-specific protective antitumor immunity. PMID: 12782590 Ref: CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice. PMID: 14522933 Ref: CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination. PMID: 14634104 |
Ref: The influence of CD25+ cells on the generation of immunity to tumour cell lines in mice. PMID: 15027488 Ref: Yogurt feeding inhibits promotion and progression of experimental colorectal cancer. PMID: 15039638 Ref: Tumour-infiltrating lymphocytes in colorectal cancer with microsatellite instability are activated and cytotoxic. PMID: 15048750 Ref: [Expression of leucocyte cell-surface antigens on colon cancer cell line HR8348]. PMID: 15067730 Ref: Dendritic cells pulsed with an anti-idiotype antibody mimicking carcinoembryonic antigen (CEA) can reverse immunological tolerance to CEA and induce antitumor immunity in CEA transgenic mice. PMID: 15256474 |
Ref: The changes of CD4+CD25+/CD4+ proportion in spleen of tumor-bearing BALB/c mice. PMID: 15679891 Ref: Large intestine intraepithelial lymphocytes from Apc+/+ and Apc+/Min mice and their modulation by indigestible carbohydrates: the IL-15/IL-15R alpha complex and CD4+ CD25+ T cells are the main targets. PMID: 15693142 Ref: CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice. PMID: 15899788 |
Ref: MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors. PMID: 16139892 Ref: CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer. PMID: 17205133 |
Ref: A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy. PMID: 17289891 Ref: Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients. PMID: 17388261 Ref: [Declining mitogen-induced polyclonal activity of peripheral blood lymphocytes as an index of immunosuppression involved in different neoplasms]. PMID: 17649734 Ref: Different forms of helper tolerance to carcinoembryonic antigen: ignorance and regulation. PMID: 17671139 Ref: Live attenuated Listeria monocytogenes effectively treats hepatic colorectal cancer metastases and is strongly enhanced by depletion of regulatory T cells. PMID: 17942940 Ref: [Anticancer immunotherapy using inactivated Sendai virus particles]. PMID: 18040151 |
Ref: Detection and functional analysis of tumor infiltrating T-lymphocytes (TIL) in liver metastases from colorectal cancer. PMID: 18521684 Ref: Dysregulation in immune functions is reflected in tumor cell cytotoxicity by peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients. PMID: 18547033 Ref: Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis. PMID: 18567620 Ref: T-cell responses to survivin in cancer patients undergoing radiation therapy. PMID: 18676762 |
Ref: Identification of CD8+CD25+Foxp3+ suppressive T cells in colorectal cancer tissue. PMID: 19022917 Ref: Lymphocyte recruitment into the tumor site is altered in patients with MSI-H colon cancer. PMID: 19165625 Ref: B7 blockade alters the balance between regulatory T cells and tumor-reactive T cells for immunotherapy of cancer. PMID: 19188167 Ref: Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice. PMID: 21475900 |
Ref: Blockade of TGF-beta enhances tumor vaccine efficacy mediated by CD8(+) T cells. PMID: 19830696 Ref: Targeted inhibition of IL-10-secreting CD25- Treg via p38 MAPK suppression in cancer immunotherapy. PMID: 20127675 Ref: PSK may suppress CD57(+) T cells to improve survival of advanced gastric cancer patients. PMID: 20229169 Ref: Combination of CTL-associated antigen-4 blockade and depletion of CD25 regulatory T cells enhance tumour immunity of dendritic cell-based vaccine in a mouse model of colon cancer. PMID: 20384858 Ref: Survival in rectal cancer is predicted by T cell infiltration of tumour-associated lymphoid nodules. PMID: 20408858 Ref: Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals. PMID: 20460483 Ref: [Effect of shenqi fuzheng injection combined with chemotherapy in treating colorectal cancer]. PMID: 20535927 Ref: Dietary fish oil alters T lymphocyte cell populations and exacerbates disease in a mouse model of inflammatory colitis. PMID: 20798218 |
Ref: Successful colon cancer eradication after chemoimmunotherapy is associated with profound phenotypic change of intratumoral myeloid cells. PMID: 21148040 Ref: Human colonic myofibroblasts promote expansion of CD4+ CD25high Foxp3+ regulatory T cells. PMID: 21376048 Ref: Inhibition and promotion of tumor growth with adeno-associated virus carcinoembryonic antigen vaccine and Toll-like receptor agonists. PMID: 21869824 Ref: Behavior of circulating CD4+CD25+Foxp3+ regulatory T cells in colon cancer patients undergoing surgery. PMID: 21915633 |
Ref: In vivo expansion of naive CD4+ CD25(high) FOXP3+ regulatory T cells in patients with colorectal carcinoma after IL-2 administration. PMID: 22276195 Ref: Accumulation of CCR4(+)CTLA-4 FOXP3(+)CD25(hi) regulatory T cells in colon adenocarcinomas correlate to reduced activation of conventional T cells. PMID: 22319577 Ref: In vitro selective depletion of CD4(+)CD25(+) regulatory T-cells from PBMC using anti-tac-SAP. PMID: 22506556 Ref: Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance toward circulating carcinoembryonic antigen in mice. PMID: 22610745 Ref: Circulating regulatory T cells of cancer patients receiving radiochemotherapy may be useful to individualize cancer treatment. PMID: 22682747 |
Ref: Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer. PMID: 22911397 Ref: Impact of preoperative serum interleukin-2 receptor alpha levels on survival and its correlation with clinicopathological parameters in colorectal cancer. PMID: 23340854 Ref: Ex vivo characterization of gammadelta T-cell repertoire in patients after adoptive transfer of Vgamma9Vdelta2 T cells expressing the interleukin-2 receptor beta-chain and the common gamma-chain. PMID: 23391461 Ref: Tim-3 expression defines regulatory T cells in human tumors. PMID: 23526963 Ref: [Changes of lymphocyte subsets before and after chemotherapy in colorectal carcinoma patients]. PMID: 23643003 |
Ref: Highly prevalent colorectal cancer-infiltrating LAP(+) Foxp3(-) T cells exhibit more potent immunosuppressive activity than Foxp3(+) regulatory T cells. PMID: 24064667 Ref: CTLA-4 blockade enhances antitumor immunity of intratumoral injection of immature dendritic cells into irradiated tumor in a mouse colon cancer model. PMID: 24316550 Ref: Norm- and hypo-fractionated radiotherapy is capable of activating human dendritic cells. PMID: 24512329 Ref: HIV infection accelerates gastrointestinal tumor outgrowth in NSG-HuPBL mice. PMID: 24593860 Ref: TLR7 ligand augments GM-CSF-initiated antitumor immunity through activation of plasmacytoid dendritic cells. PMID: 24830413 Ref: Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities. PMID: 25436113 Ref: The influence of the CHIEF pathway on colorectal cancer-specific mortality. PMID: 25541970 |
Ref: Novel expression of Neuropilin 1 on human tumor-infiltrating lymphocytes in colorectal cancer liver metastases. PMID: 25351619 Ref: Surface profiles of live colorectal cancer cells and tumor infiltrating lymphocytes from surgical samples correspond to prognostic categories. PMID: 25445327 Ref: Tumor-induced myeloid-derived suppressor cells promote tumor progression through oxidative metabolism in human colorectal cancer. PMID: 25638150 Ref: Cytokine profile and prognostic significance of high neutrophil-lymphocyte ratio in colorectal cancer. PMID: 25688736 Ref: Combination effect of regulatory T-cell depletion and ionizing radiation in mouse models of lung and colon cancer. PMID: 25754628 Ref: [Relationship between CD4(+)CD25(High)CD127(low) regularly T cells in the peripheral blood and tumor regression after neoadjuvant therapy in patients with rectal cancer]. PMID: 25940180 Ref: Joint prognostic effect of obesity and chronic systemic inflammation in patients with metastatic colorectal cancer. PMID: 25975416 Ref: Artesunate down-regulates immunosuppression from colorectal cancer Colon26 and RKO cells in vitro by decreasing transforming growth factor beta1 and interleukin-10. PMID: 25978851 Ref: Preferential expansion of pro-inflammatory Tregs in human non-small cell lung cancer. PMID: 26047578 Ref: Innate Response to Human Cancer Cells with or without IL-2 Receptor Common gamma-Chain Function in NOD Background Mice Lacking Adaptive Immunity. PMID: 26170385 |
Ref: Accumulation of FoxP3+ T regulatory cells in the tumor microenvironment of human colorectal adenomas. PMID: 26724144 Ref: Preventive Effects of Bee Venom Derived Phospholipase A(2) on Oxaliplatin-Induced Neuropathic Pain in Mice. PMID: 26797636 Ref: Bone morphogenetic protein 7 is associated with the nodal invasion of colon cancer. PMID: 26998065 Ref: Enrichment of Inflammatory IL-17 and TNF-alpha Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1. PMID: 27014625 Ref: Xenogeneic cell-based vaccine therapy for colorectal cancer: Safety, association of clinical effects with vaccine-induced immune responses. PMID: 27565847 Ref: Determination of a CD4(+)CD25(-)FoxP3(+) T cells subset in tumor-draining lymph nodes of colorectal cancer secreting IL-2 and IFN-gamma. PMID: 27619682 Ref: Proteomic Approaches to Biomarker Discovery in Cutaneous T-Cell Lymphoma. PMID: 27821903 |
Ref: Trans-scirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells. PMID: 28489607 |
Ref: An increased CD25-positive intestinal regulatory T lymphocyte population is dependent upon Cox-2 activity in the Apc(min/+) model. PMID: 28940183 Ref: Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer. PMID: 29295954 Ref: Co-expression of LAG3 and TIM3 identifies a potent Treg population that suppresses macrophage functions in colorectal cancer patients. PMID: 29905955 |