Primary Site >> Colorectal Cancer
Gene >> IL21
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Ref: Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts. PMID: 12637939 |
Ref: IL-21 induces tumor rejection by specific CTL and IFN-gamma-dependent CXC chemokines in syngeneic mice. PMID: 14734732 |
Ref: In situ tumor vaccination with adenovirus vectors encoding measles virus fusogenic membrane proteins and cytokines. PMID: 17589921 |
Ref: Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity. PMID: 19915059 |
Ref: Synthesis and efficient hepatocyte targeting of galactosylated chitosan as a gene carrier in vitro and in vivo. PMID: 21656667 Ref: Nutritional influences in selected gastrointestinal diseases. PMID: 21734379 Ref: Involvement of interleukin-21 in the regulation of colitis-associated colon cancer. PMID: 21987656 |
Ref: Interleukin-21 in cancer immunotherapy: Friend or foe? PMID: 22737612 Ref: Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis. PMID: 22738913 Ref: Interleukin 21 impairs tumor immunosurveillance of colitis-associated colorectal cancer. PMID: 22754778 Ref: The changes of Th17 cells and the related cytokines in the progression of human colorectal cancers. PMID: 22994684 |
Ref: Interplay between T(h)1 and T(h)17 effector T-cell pathways in the pathogenesis of spontaneous colitis and colon cancer in the Galphai2-deficient mouse. PMID: 22962436 Ref: Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. PMID: 24138885 Ref: Role of TH17 cytokines in the control of colorectal cancer. PMID: 24498548 |
Ref: [Role of Th17 lymphocytes in pathogenesis of colorectal cancer]. PMID: 24491894 |
Ref: Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. PMID: 25174402 Ref: Interleukin21 promotes the development of ulcerative colitis and regulates the proliferation and secretion of follicular T helper cells in the colitides microenvironment. PMID: 25371082 Ref: Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis. PMID: 25839161 |
Ref: Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer. PMID: 25994220 Ref: Deficiency of IL-17A, but not the prototypical Th17 transcription factor RORgammat, decreases murine spontaneous intestinal tumorigenesis. PMID: 26559812 |
Ref: Deficiency of the immunostimulatory cytokine IL-21 promotes intestinal neoplasia via dysregulation of the Th1/Th17 axis. PMID: 28197386 Ref: Chitosan nanoparticle-based delivery of fused NKG2D-IL-21 gene suppresses colon cancer growth in mice. PMID: 28450784 Ref: Fusobacterium Nucleatum Subspecies Animalis Influences Proinflammatory Cytokine Expression and Monocyte Activation in Human Colorectal Tumors. PMID: 28483840 Ref: Increased expression of interleukin-21 along colorectal adenoma-carcinoma sequence and its predicating significance in patients with sporadic colorectal cancer. PMID: 28887120 |
Ref: Th17 cytokine profiling of colorectal cancer patients with or without enterovirus 71 antigen expression. PMID: 29175261 Ref: Interleukin 21 treatment in a murine model as a novel potential cytokine immunotherapy for colon cancer. PMID: 29616746 Ref: Neutralizing FGF4 protein in conditioned medium of IL-21-silenced HCT116 cells restores the migratory activity of the colorectal cancer cells. PMID: 29802489 Ref: Follicular helper T cells promote the effector functions of CD8(+) T cells via the provision of IL-21, which is downregulated due to PD-1/PD-L1-mediated suppression in colorectal cancer. PMID: 30205088 |