Primary Site >> Colorectal Cancer
Gene >> IGFBP4
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Ref: Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein. PMID: 1709585 |
Ref: des-(1-3)-IGF-I, an insulin-like growth factor analog used to mimic a potential IGF-II autocrine loop, promotes the differentiation of human colon-carcinoma cells. PMID: 1281142 |
Ref: Episomal expression of sense and antisense insulin-like growth factor (IGF)-binding protein-4 complementary DNA alters the mitogenic response of a human colon cancer cell line (HT-29) by mechanisms that are independent of and dependent upon IGF-I. PMID: 7527300 |
Ref: Cell polarity of the insulin-like growth factor system in human intestinal epithelial cells. Unique apical sorting of insulin-like growth factor binding protein-6 in differentiated human colon cancer cells. PMID: 7542277 |
Ref: Proliferation and differentiation of a human colon cancer cell line (CaCo2) is associated with significant changes in the expression and secretion of insulin-like growth factor (IGF) IGF-II and IGF binding protein-4: role of IGF-II. PMID: 8612513 Ref: Expression of IGFBP-2, -3, and -4 mRNA during differentiation of Caco-2 colon epithelial cells. PMID: 8944682 |
Ref: Cloning of the functional promoter for human insulin-like growth factor binding protein-4 gene: endogenous regulation. PMID: 8977421 Ref: Insulin-like growth factors and their binding proteins in human colonocytes: preferential degradation of insulin-like growth factor binding protein 2 in colonic cancers. PMID: 9218734 Ref: Surface-bound plasmin induces selective proteolysis of insulin-like-growth-factor (IGF)-binding protein-4 (IGFBP-4) and promotes autocrine IGF-II bio-availability in human colon-carcinoma cells. PMID: 9311602 Ref: Insulin-like growth factor binding proteins as mediators of IGF-I effects on colon cancer cell proliferation. PMID: 9386991 |
Ref: Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. PMID: 9731515 |
Ref: Synthetic low-calcaemic vitamin D(3) analogues inhibit secretion of insulin-like growth factor II and stimulate production of insulin-like growth factor-binding protein-6 in conjunction with growth suppression of HT-29 colon cancer cells. PMID: 11604234 |
Ref: Inhibition of Caco-2 cell proliferation by all-trans retinoic acid: role of insulin-like growth factor binding protein-6. PMID: 11807815 |
Ref: trans-10, cis-12 conjugated linoleic acid reduces insulin-like growth factor-II secretion in HT-29 human colon cancer cells. PMID: 14585185 Ref: Interleukin-1beta (IL-1beta) and IL-6 modulate insulin-like growth factor-binding protein (IGFBP) secretion in colon cancer epithelial (Caco-2) cells. PMID: 14656210 |
Ref: Identification of a novel SP3 binding site in the promoter of human IGFBP4 gene: role of SP3 and AP-1 in regulating promoter activity in CaCo2 cells. PMID: 14767471 Ref: Insulin-like growth factor (IGF)-binding protein-4 inhibits colony formation of colorectal cancer cells by IGF-independent mechanisms. PMID: 14996716 |
Ref: Transcriptome analysis of a human colorectal cancer cell line shows molecular targets of insulin-like growth factor-binding protein-4 overexpression. PMID: 15455346 Ref: Immunoprofiles of 11 biomarkers using tissue microarrays identify prognostic subgroups in colorectal cancer. PMID: 16207476 |
Ref: Biology of insulin-like growth factor binding protein-4 and its role in cancer (review). PMID: 16685432 |
Ref: Insulin-like growth factor binding protein-4 gene therapy increases apoptosis by altering Bcl-2 and Bax proteins and decreases angiogenesis in colorectal cancer. PMID: 17332927 Ref: Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. PMID: 17615082 Ref: Increased apoptosis and decreased proliferation of colorectal cancer cells using insulin-like growth factor binding protein-4 gene delivered locally by gene transfer. PMID: 17824980 Ref: Role of insulin-like growth factor binding protein-4 in prevention of colon cancer. PMID: 17988381 |
Ref: Microarray analysis reveals that leptin induces autocrine/paracrine cascades to promote survival and proliferation of colon epithelial cells in an Apc genotype-dependent fashion. PMID: 17620308 |
Ref: SOX9 directly regulates IGFBP-4 in the intestinal epithelium. PMID: 23660500 |
Ref: Glucagon-like petide-2 acts on colon cancer myofibroblasts to stimulate proliferation, migration and invasion of both myofibroblasts and cancer cells via the IGF pathway. PMID: 28363795 |