Primary Site >> Colorectal Cancer
Gene >> IGFBP2
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Ref: Insulin-like growth-factor-binding protein gene expression and protein production by human tumour cell lines. PMID: 1377187 |
Ref: Alterations in serum levels of insulin-like growth factors and insulin-like growth-factor-binding proteins in patients with colorectal cancer. PMID: 7514152 |
Ref: Cell polarity of the insulin-like growth factor system in human intestinal epithelial cells. Unique apical sorting of insulin-like growth factor binding protein-6 in differentiated human colon cancer cells. PMID: 7542277 |
Ref: Proliferation and differentiation of a human colon cancer cell line (CaCo2) is associated with significant changes in the expression and secretion of insulin-like growth factor (IGF) IGF-II and IGF binding protein-4: role of IGF-II. PMID: 8612513 Ref: Expression of IGFBP-2, -3, and -4 mRNA during differentiation of Caco-2 colon epithelial cells. PMID: 8944682 |
Ref: Insulin-like growth factors and their binding proteins in human colonocytes: preferential degradation of insulin-like growth factor binding protein 2 in colonic cancers. PMID: 9218734 Ref: Surface-bound plasmin induces selective proteolysis of insulin-like-growth-factor (IGF)-binding protein-4 (IGFBP-4) and promotes autocrine IGF-II bio-availability in human colon-carcinoma cells. PMID: 9311602 Ref: Insulin-like growth factor binding proteins as mediators of IGF-I effects on colon cancer cell proliferation. PMID: 9386991 |
Ref: Insulin-like growth factor-binding protein-2 inhibits proliferation of human embryonic kidney fibroblasts and of IGF-responsive colon carcinoma cell lines. PMID: 9742949 Ref: Role of insulin-like growth factor-I (IGF-I) receptor, IGF-I, and IGF binding protein-2 in human colorectal cancers. PMID: 10985759 |
Ref: Circulating insulin-like growth factor II and colorectal adenomas. PMID: 10999841 Ref: Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women. PMID: 11018095 Ref: Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer. PMID: 11044360 |
Ref: Increased levels of insulin-like growth factor binding protein-2 in sera and tumours from patients with colonic neoplasia with and without acromegaly. PMID: 11318786 Ref: Synthetic low-calcaemic vitamin D(3) analogues inhibit secretion of insulin-like growth factor II and stimulate production of insulin-like growth factor-binding protein-6 in conjunction with growth suppression of HT-29 colon cancer cells. PMID: 11604234 |
Ref: Inhibition of Caco-2 cell proliferation by all-trans retinoic acid: role of insulin-like growth factor binding protein-6. PMID: 11807815 Ref: Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. PMID: 12096082 Ref: Trans-10,cis-12-conjugated linoleic acid inhibits Caco-2 colon cancer cell growth. PMID: 12121883 Ref: Insulin-like growth factor II and colorectal cancer risk in women. PMID: 12223436 |
Ref: Plasma insulin, IGF-binding proteins-1 and -2 and risk of colorectal cancer: a prospective study in northern Sweden. PMID: 12925961 Ref: trans-10, cis-12 conjugated linoleic acid reduces insulin-like growth factor-II secretion in HT-29 human colon cancer cells. PMID: 14585185 Ref: Interleukin-1beta (IL-1beta) and IL-6 modulate insulin-like growth factor-binding protein (IGFBP) secretion in colon cancer epithelial (Caco-2) cells. PMID: 14656210 Ref: Increased activity of catalase in tumor cells overexpressing IGFBP-2. PMID: 14710363 |
Ref: Expression patterns of cell cycle and apoptosis-related genes in a multidrug-resistant human colon carcinoma cell line. PMID: 15180185 |
Ref: Isolated isoflavones do not affect the circulating insulin-like growth factor system in men at increased colorectal cancer risk. PMID: 17237315 Ref: Matrix metalloproteinase-7 triggers the matricrine action of insulin-like growth factor-II via proteinase activity on insulin-like growth factor binding protein 2 in the extracellular matrix. PMID: 17359288 Ref: Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition. PMID: 17372899 Ref: Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer. PMID: 17991659 |
Ref: Microarray analysis reveals that leptin induces autocrine/paracrine cascades to promote survival and proliferation of colon epithelial cells in an Apc genotype-dependent fashion. PMID: 17620308 Ref: Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells. PMID: 18317448 Ref: No effect of red clover-derived isoflavone intervention on the insulin-like growth factor system in women at increased risk of colorectal cancer. PMID: 18842999 |
Ref: IGFBP-2 overexpression reduces the appearance of dysplastic aberrant crypt foci and inhibits growth of adenomas in chemically induced colorectal carcinogenesis. PMID: 19142966 Ref: IGF-I, IGF-II, IGFBP2, IGFBP3 and acid-labile subunit (ALS) in colorectal cancer patients before surgery and during one year follow up in relation to age. PMID: 19482725 |
Ref: Plasma insulin-like growth factor-binding protein-2 levels as diagnostic and prognostic biomarker of colorectal cancer. PMID: 20157191 |
Ref: The development of composite circulating biomarker models for use in anticancer drug clinical development. PMID: 20549702 Ref: Do insulin-like growth factor associated proteins qualify as a tumor marker? Results of a prospective study in 163 cancer patients. PMID: 22024424 |
Ref: Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women. PMID: 22277732 Ref: Elevated serum antibodies against insulin-like growth factor-binding protein-2 allow detecting early-stage cancers: evidences from glioma and colorectal carcinoma studies. PMID: 22357443 |
Ref: Global analysis of L1-transcriptomes identified IGFBP-2 as a target of ezrin and NF-kappaB signaling that promotes colon cancer progression. PMID: 22869145 Ref: Circulation insulin-like growth factor peptides and colorectal cancer risk: an updated systematic review and meta-analysis. PMID: 23269623 Ref: The prognostic role of ephrin A2 and endothelial growth factor receptor pathway mediators in patients with advanced colorectal cancer treated with cetuximab. PMID: 24050852 Ref: Detection and identification of oxidized insulin-like growth factor-binding proteins and receptors in patients with colorectal carcinoma. PMID: 24051179 |
Ref: Molecular forms of the insulin-like growth factor-binding protein-2 in patients with colorectal cancer. PMID: 24275430 Ref: Insulin-like growth factors (IGF), IGF-binding proteins (IGFBP), and vascular endothelial growth factor (VEGF) in blood serum of patients with colorectal cancer. PMID: 24770758 Ref: Body size, physical activity, early-life energy restriction, and associations with methylated insulin-like growth factor-binding protein genes in colorectal cancer. PMID: 24972776 |
Ref: Letter to the editor concerning 'Elevated serum antibodies against insulin-like growth factor-binding protein-2 allow detecting early-stage cancers: evidences from glioma and colorectal carcinoma studies'. PMID: 25355718 Ref: Biomarker signatures correlate with clinical outcome in refractory metastatic colorectal cancer patients receiving bevacizumab and everolimus. PMID: 25695956 Ref: Blood-based protein biomarker panel for the detection of colorectal cancer. PMID: 25793510 Ref: Linking patient outcome to high throughput protein expression data identifies novel regulators of colorectal adenocarcinoma aggressiveness. PMID: 26097693 |
Ref: A four gene signature predictive of recurrent prostate cancer. PMID: 27966447 Ref: Expression of RNA-binding Motif Protein 3 (RBM3) and Cold-inducible RNA-binding protein (CIRP) Is Associated with Improved Clinical Outcome in Patients with Colon Cancer. PMID: 28373441 |
Ref: Cellular prion protein and gamma-synuclein overexpression in LS 174T colorectal cancer cell drives endothelial proliferation-to-differentiation switch. PMID: 29527422 |