Primary Site >> Liver Cancer
Gene >> IGF2
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Ref: Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth. PMID: 1568224 |
Ref: Allelic-expression imbalance of the insulin-like growth factor 2 gene in hepatocellular carcinoma and underlying disease. PMID: 8622877 Ref: M6P/IGF2 receptor: a candidate breast tumor suppressor gene. PMID: 8649861 Ref: Increased expression of insulin-like growth factor 2 in hepatocellular carcinoma is primarily regulated at the transcriptional level. PMID: 8804354 |
Ref: Altered transcriptional regulation of the insulin-like growth factor 2 gene in human hepatocellular carcinoma. PMID: 9142213 Ref: Disrupted IGF2 promoter control by silencing of promoter P1 in human hepatocellular carcinoma. PMID: 9158004 Ref: Genomic imprinting and Igf2 influence liver tumorigenesis and loss of heterozygosity in SV40 T antigen transgenic mice. PMID: 9377577 Ref: Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor gene correlates with poor differentiation in early breast carcinomas. PMID: 9413941 Ref: Biallelic expression of the H19 and IGF2 genes in hepatocellular carcinoma. PMID: 9570364 |
Ref: Reactivation of the maternally imprinted IGF2 allele in TGFalpha induced hepatocellular carcinomas in mice. PMID: 9464538 Ref: In situ detection of insulin-like growth factor II (IGF2) and H19 gene expression in hepatocellular carcinoma. PMID: 9609998 Ref: Case report: Insulin-like growth factor II expression in hepatocellular carcinoma with alcoholic liver fibrosis accompanied by hypoglycaemia. PMID: 9737571 Ref: Loss of imprinting of the insulin-like growth factor II gene in mouse hepatocellular carcinoma cell lines. PMID: 9869454 |
Ref: IGF-II and IL-2 act synergistically to alter HDAC1 expression following treatments with trichostatin a. PMID: 10880258 Ref: p57(KIP2) is not mutated in hepatoblastoma but shows increased transcriptional activity in a comparative analysis of the three imprinted genes p57(KIP2), IGF2, and H19. PMID: 11021841 Ref: The H19 endodermal enhancer is required for Igf2 activation and tumor formation in experimental liver carcinogenesis. PMID: 11175353 |
Ref: Cloning and characterization of a novel 90 kDa 'companion' auto-antigen of p62 overexpressed in cancer. PMID: 12118381 Ref: Comparison of gene expression profiles between hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma by oligonucleotide microarray data on the basis of a supervised learning method. PMID: 12124323 |
Ref: A methylated oligonucleotide inhibits IGF2 expression and enhances survival in a model of hepatocellular carcinoma. PMID: 12531883 Ref: Transcriptional profiling in hepatoblastomas using high-density oligonucleotide DNA array. PMID: 12935928 Ref: Growth promotion of HepG2 hepatoma cells by antisense-mediated knockdown of glypican-3 is independent of insulin-like growth factor 2 signaling. PMID: 14508064 Ref: Loss of parental-specific methylation at the IGF2 locus in human hepatocellular carcinoma. PMID: 14595760 |
Ref: Oncofetal splice-pattern of the human H19 gene. PMID: 15147959 Ref: Alterations in specific gene expression and focal neoplastic growth during spontaneous hepatocarcinogenesis in albumin-SV40 T antigen transgenic rats. PMID: 15224347 Ref: [Study on the expression and genomic imprinting status of insulin-like growth factor 2 gene in hepatocellular carcinoma]. PMID: 15225429 Ref: [The imprinting status and expression of insulin-like growth factor 2 gene in human hepatocellular carcinoma]. PMID: 15291100 Ref: Severe hypoglycemia and hypokalemia in association with liver metastases of gastric cancer. PMID: 15497518 Ref: Imbalance in expression levels of insulin-like growth factor 2 and H19 transcripts linked to progression of hepatocellular carcinoma. PMID: 15736456 |
Ref: The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma. PMID: 15684377 |
Ref: IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma. PMID: 16750516 Ref: Clinical features of insulin-like growth factor-II producing non-islet-cell tumor hypoglycemia. PMID: 16860583 Ref: Impact of IGF-1R/EGFR cross-talks on hepatoma cell sensitivity to gefitinib. PMID: 16988945 |
Ref: [The aberrant imprinting of insulin-like growth factor II and H19 in human hepatocellular carcinoma]. PMID: 17294726 Ref: Rapid identification of promoter hypermethylation in hepatocellular carcinoma by pyrosequencing of etiologically homogeneous sample pools. PMID: 17690210 Ref: Identification of candidate biomarkers for hepatocellular carcinoma through pre-cancerous expression analysis in an HBx transgenic mouse. PMID: 18245957 |
Ref: Hypomethylated and hypermethylated profiles of H19DMR are associated with the aberrant imprinting of IGF2 and H19 in human hepatocellular carcinoma. PMID: 18358696 Ref: Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma. PMID: 18803353 |
Ref: Differential roles of insulin-like growth factor receptor- and insulin receptor-mediated signaling in the phenotypes of hepatocellular carcinoma cells. PMID: 19724677 Ref: Betulinic acid treatment promotes apoptosis in hepatoblastoma cells. PMID: 19724925 Ref: Molecular mechanisms underlying hepatocellular carcinoma. PMID: 21994573 |
Ref: IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage. PMID: 20206398 Ref: Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition. PMID: 20860815 |
Ref: Epidermal growth factor induces cytokeratin 19 expression accompanied by increased growth abilities in human hepatocellular carcinoma. PMID: 20856226 Ref: Overexpression of the IGF2-mRNA binding protein p62 in transgenic mice induces a steatotic phenotype. PMID: 21145819 Ref: Advanced computational biology methods identify molecular switches for malignancy in an EGF mouse model of liver cancer. PMID: 21464922 Ref: Molecular signatures and prognosis of hepatocellular carcinoma. PMID: 21769080 |
Ref: Igf2-derived intronic miR-483 promotes mouse hepatocellular carcinoma cell proliferation. PMID: 22052201 Ref: IGFBP3 impedes aggressive growth of pediatric liver cancer and is epigenetically silenced in vascular invasive and metastatic tumors. PMID: 22401581 Ref: Insulin-like growth factor 2 gene methylation in peripheral blood mononuclear cells of patients with hepatitis C related cirrhosis or hepatocellular carcinoma. PMID: 22902352 Ref: Development of targeted therapy for a broad spectrum of cancers (pancreatic cancer, ovarian cancer, glioblastoma and HCC) mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences. PMID: 22993648 |
Ref: IGF2 mRNA binding protein p62/IMP2-2 in hepatocellular carcinoma: antiapoptotic action is independent of IGF2/PI3K signaling. PMID: 23257922 Ref: Overexpression of GPC3 inhibits hepatocellular carcinoma cell proliferation and invasion through induction of apoptosis. PMID: 23338845 Ref: Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients. PMID: 23526469 |
Ref: Management of endocrine disease: a clinical update on tumor-induced hypoglycemia. PMID: 24459236 Ref: Association of IGF1R polymorphisms with the development of HBV-related hepatocellular carcinoma. PMID: 24758241 Ref: The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets. PMID: 25225571 Ref: Fatty acid esters of phloridzin induce apoptosis of human liver cancer cells through altered gene expression. PMID: 25229655 Ref: Induction of apoptosis by IGFBP3 overexpression in hepatocellular carcinoma cells. PMID: 25556430 |
Ref: Hepatitis B virus X protein promotes P3 transcript expression of the insulin-like growth factor 2 gene via inducing hypomethylation of P3 promoter in hepatocellular carcinoma. PMID: 24423280 Ref: Dysregulated serum response factor triggers formation of hepatocellular carcinoma. PMID: 25266280 Ref: MiR-216b is involved in pathogenesis and progression of hepatocellular carcinoma through HBx-miR-216b-IGF2BP2 signaling pathway. PMID: 25741595 Ref: PU.1 Is Identified as a Novel Metastasis Suppressor in Hepatocellular Carcinoma Regulating the miR-615-5p/IGF2 Axis. PMID: 25987019 Ref: Differential reactivation of fetal/neonatal genes in mouse liver tumors induced in cirrhotic and non-cirrhotic conditions. PMID: 26011625 Ref: Disruption of human vigilin impairs chromosome condensation and segregation. PMID: 26032007 Ref: Targeted deep DNA methylation analysis of circulating cell-free DNA in plasma using massively parallel semiconductor sequencing. PMID: 26077425 Ref: miR-1275: A single microRNA that targets the three IGF2-mRNA-binding proteins hindering tumor growth in hepatocellular carcinoma. PMID: 26160756 Ref: Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. PMID: 26409325 |
Ref: The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma. PMID: 26756219 Ref: Hemoglobins, Hemorphins, and 11p15.5 Chromosomal Region in Cancer Biology and Immunity with Special Emphasis for Brain Tumors. PMID: 26935297 Ref: Loss of insulin-like growth factor II imprinting is a hallmark associated with enhanced chemo/radiotherapy resistance in cancer stem cells. PMID: 27275535 Ref: IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models. PMID: 27614046 Ref: Liver cancer: IGF2 - an epigenetic oncodriver in HCC. PMID: 27677717 Ref: Prohibitin 1 Regulates the H19-Igf2 Axis and Proliferation in Hepatocytes. PMID: 27687727 |
Ref: beta-ionone modulates the expression of miRNAs and genes involved in the metastatic phenotype of microdissected persistent preneoplastic lesions in rats submitted to hepatocarcinogenesis. PMID: 27061051 Ref: Novel deletion in 11p15.5 imprinting center region 1 in a patient with Beckwith-Wiedemann syndrome provides insight into distal enhancer regulation and tumorigenesis. PMID: 27650505 Ref: Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin. PMID: 28373218 Ref: Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells. PMID: 28481368 Ref: Pro-IGF2-induced hypoglycaemia associated with hepatocellular carcinoma. PMID: 28567293 Ref: The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy. PMID: 28729397 Ref: Targeting H19, an Imprinted Long Non-Coding RNA, in Hepatic Functions and Liver Diseases. PMID: 28933364 |
Ref: Epigenetic alterations contribute to promoter activity of imprinting gene IGF2. PMID: 29413895 Ref: Insulin-Like Growth Factor (IGF) System in Liver Diseases. PMID: 29702590 Ref: Tissue miRNA 483-3p expression predicts tumor recurrence after surgical resection in histologically advanced hepatocellular carcinomas. PMID: 29707155 Ref: Transgenic expression of the RNA binding protein IMP2 stabilizes miRNA targets in murine microsteatosis. PMID: 29859241 Ref: High-density single cell mRNA sequencing to characterize circulating tumor cells in hepatocellular carcinoma. PMID: 30068984 Ref: Identification of miRNA and mRNA expression profiles by PCR microarray in hepatitis B virusassociated hepatocellular carcinoma. PMID: 30272372 Ref: Investigating Pathogenic and Hepatocarcinogenic Mechanisms from Normal Liver to HCC by Constructing Genetic and Epigenetic Networks via Big Genetic and Epigenetic Data Mining and Genome-Wide NGS Data Identification. PMID: 30344796 |