Primary Site >> Colorectal Cancer
Gene >> IGF2
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Ref: Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas. PMID: 3779638 |
Ref: Presence of somatomedin receptors on primary human breast and colon carcinomas. PMID: 2961436 Ref: Simultaneous production of IGF-I and EGF competing growth factors by HT-29 human colon cancer line. PMID: 3500134 |
Ref: Production of insulin-like growth factor II (IGF-II) and different forms of IGF-binding proteins by HT-29 human colon carcinoma cell line. PMID: 1694180 Ref: Abnormal expression and structural modification of the insulin-like growth-factor-II gene in human colorectal tumors. PMID: 1975564 |
Ref: Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein. PMID: 1709585 Ref: Tumor IGF-II content in a patient with a colon adenocarcinoma correlates with abnormal expression of the gene. PMID: 1713573 Ref: Type-II insulin-like growth-factor receptor in conditioned medium from HT-29 human colon carcinoma cell line. PMID: 1848538 |
Ref: des-(1-3)-IGF-I, an insulin-like growth factor analog used to mimic a potential IGF-II autocrine loop, promotes the differentiation of human colon-carcinoma cells. PMID: 1281142 Ref: Expression of type I, but not type II insulin-like growth factor receptor on both undifferentiated and differentiated HT29 human colon carcinoma cell line. PMID: 1322432 Ref: Insulin-like growth factor II in two human colon-carcinoma cell lines: gene structure and expression, and protein secretion. PMID: 1399116 Ref: Cellular and molecular mechanisms of hepatocarcinogenesis. PMID: 1439879 Ref: Pattern of growth factor, proto-oncogene and carcinoembryonic antigen gene expression in human colorectal carcinoma cell lines. PMID: 1495747 Ref: Growth regulation and co-stimulation of human colorectal cancer cell lines by insulin-like growth factor I, II and transforming growth factor alpha. PMID: 1558785 |
Ref: Alterations in serum levels of insulin-like growth factors and insulin-like growth-factor-binding proteins in patients with colorectal cancer. PMID: 7514152 Ref: Expression of IGF-II and IGF-binding proteins by colon cancer cells in relation to growth response to IGFs. PMID: 7524348 Ref: Episomal expression of sense and antisense insulin-like growth factor (IGF)-binding protein-4 complementary DNA alters the mitogenic response of a human colon cancer cell line (HT-29) by mechanisms that are independent of and dependent upon IGF-I. PMID: 7527300 Ref: Expression of insulin-like growth factor (IGF)-II and IGF-I receptor during proliferation and differentiation of CaCo-2 human colon carcinoma cells. PMID: 7848910 Ref: Blockade of the insulin-like growth-factor-I receptor inhibits growth of human colorectal cancer cells: evidence of a functional IGF-II-mediated autocrine loop. PMID: 8050827 Ref: Human colon carcinoma cells (CaCo-2) synthesize IGF-II and express IGF-I receptors and IGF-II/M6P receptors. PMID: 9397946 |
Ref: Constitutive or inducible overexpression of the IGF-2 gene in cells of a human colon carcinoma cell line. PMID: 7531153 Ref: Cell polarity of the insulin-like growth factor system in human intestinal epithelial cells. Unique apical sorting of insulin-like growth factor binding protein-6 in differentiated human colon cancer cells. PMID: 7542277 Ref: Insulin-like growth factor-II expression in carcinoma in colon cell lines: implications for autocrine actions. PMID: 7627387 Ref: IGF-2 autocrine stimulation in tumorigenic clones of a human colon-carcinoma cell line. PMID: 7759165 |
Ref: Proliferation and differentiation of a human colon cancer cell line (CaCo2) is associated with significant changes in the expression and secretion of insulin-like growth factor (IGF) IGF-II and IGF binding protein-4: role of IGF-II. PMID: 8612513 Ref: Constitutive insulin-like growth factor-II expression interferes with the enterocyte-like differentiation of CaCo-2 cells. PMID: 8626497 Ref: Differential effect of interleukin-4 and transforming growth factor beta 1 on expression of proto-oncogenes and autocrine insulin-like growth factor II in colorectal carcinoma cells. PMID: 8645306 Ref: Coordinate expression of insulin-like growth factor II (IGF-II) and IGF-II/mannose-6-phosphate receptor mRNA and stable expression of IGF-I receptor mRNA during differentiation of human colon carcinoma cells (Caco-2). PMID: 8765974 Ref: Relaxation of imprinting of the insulin-like growth factor II gene in colorectal cancer. PMID: 8913273 Ref: IGF2 but not H19 shows loss of imprinting in human glioma. PMID: 8968084 |
Ref: Coexpression of stromelysin-3 and insulin-like growth factor II in tumors of ectodermal, mesodermal, and endodermal origin: indicator of a fetal cell phenotype. PMID: 9177406 Ref: Insulin-like growth factors and their binding proteins in human colonocytes: preferential degradation of insulin-like growth factor binding protein 2 in colonic cancers. PMID: 9218734 Ref: Association between CpG island methylation and microsatellite instability in colorectal cancer. PMID: 9269998 Ref: Surface-bound plasmin induces selective proteolysis of insulin-like-growth-factor (IGF)-binding protein-4 (IGFBP-4) and promotes autocrine IGF-II bio-availability in human colon-carcinoma cells. PMID: 9311602 Ref: Effect of aspirin on cell proliferation and differentiation of colon adenocarcinoma Caco-2 cells. PMID: 9399670 |
Ref: The role of glucagon administration in the diagnosis and treatment of patients with tumor hypoglycemia. PMID: 9554538 Ref: Expression of insulin-like growth factor-2 can predict the prognosis of human colorectal cancer patients: correlation with tumor progression, proliferative activity and survival. PMID: 9560057 Ref: Differential activation of IGF-II promoters P3 and P4 in Caco-2 cells during growth and differentiation. PMID: 9609759 Ref: OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson-Golabi-Behmel overgrowth syndrome, induces apoptosis in a cell line-specific manner. PMID: 9628896 Ref: Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability. PMID: 9809551 Ref: Sequence alterations of insulin-like growth factor binding protein 3 in neoplastic and normal gastrointestinal tissues. PMID: 9809981 Ref: Aging and DNA methylation in colorectal mucosa and cancer. PMID: 9850084 |
Ref: Possible paracrine mechanism of insulin-like growth factor-2 in the development of liver metastases from colorectal carcinoma. PMID: 9921969 Ref: Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. PMID: 10203281 Ref: IGF-II in primary human colorectal tumors: peptide level, activated promoters, parental imprinting and gene rearrangement. PMID: 10226796 Ref: Analysis of IGF2 gene imprinting in breast and colorectal cancer by allele specific-PCR. PMID: 10398115 Ref: IGF-I and IGF-II in relation to colorectal cancer. PMID: 10449601 Ref: Antagonistic Analogs of Growth Hormone-releasing Hormone: New Potential Antitumor Agents. PMID: 10542394 Ref: [Relationship between insulin-like growth factor II and prognosis of colorectal cancer]. PMID: 11829934 |
Ref: Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice. PMID: 10706126 Ref: Antagonists of growth hormone-releasing hormone (GH-RH) inhibit IGF-II production and growth of HT-29 human colon cancers. PMID: 10817510 Ref: Multipoint imprinting analysis in sporadic colorectal cancers with and without microsatellite instability. PMID: 10891541 Ref: Aging, methylation and cancer. PMID: 10963127 Ref: Circulating insulin-like growth factor II and colorectal adenomas. PMID: 10999841 Ref: Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer. PMID: 11044360 Ref: Analysis of genomic imprinting of insulin-like growth factor 2 in colorectal cancer. PMID: 11053988 Ref: IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in Caco-2 human colon carcinoma cells. PMID: 11114729 |
Ref: Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer. PMID: 11120891 Ref: Insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced but not basal proliferation and adhesion of LIM 1215 colon cancer cells. PMID: 11306178 Ref: Increased levels of insulin-like growth factor binding protein-2 in sera and tumours from patients with colonic neoplasia with and without acromegaly. PMID: 11318786 Ref: Loss of imprinting of long QT intronic transcript 1 in colorectal cancer. PMID: 11340379 Ref: Insulin-like growth factor-II renders LIM 2405 human colon cancer cells resistant to butyrate-induced apoptosis: a potential mechanism for colon cancer cell survival in vivo. PMID: 11577001 Ref: Synthetic low-calcaemic vitamin D(3) analogues inhibit secretion of insulin-like growth factor II and stimulate production of insulin-like growth factor-binding protein-6 in conjunction with growth suppression of HT-29 colon cancer cells. PMID: 11604234 Ref: Large scale mapping of methylcytosines in CTCF-binding sites in the human H19 promoter and aberrant hypomethylation in human bladder cancer. PMID: 11726548 Ref: IGF-1, IGF-2 and IGFBP-3 in prediagnostic serum: association with colorectal cancer in a cohort of Chinese men in Shanghai. PMID: 11742490 |
Ref: Inhibition of Caco-2 cell proliferation by all-trans retinoic acid: role of insulin-like growth factor binding protein-6. PMID: 11807815 Ref: Relevance of biologic markers in colorectal carcinoma: a comparative study of a broad panel. PMID: 11857296 Ref: Insulin-like growth factor-I has a biphasic effect on colon carcinoma cells through transient inactivation of forkhead1, initially mitogenic, then mediating growth arrest and differentiation. PMID: 11920634 Ref: DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. PMID: 11932749 Ref: Development of a highly specialized cDNA array for the study and diagnosis of epithelial ovarian cancer. PMID: 12019173 Ref: Decreased production of insulin-like growth factor-binding protein (IGFBP)-6 by transfection of colon cancer cells with an antisense IGFBP-6 cDNA construct leads to stimulation of cell proliferation. PMID: 12084030 Ref: Trans-10,cis-12-conjugated linoleic acid inhibits Caco-2 colon cancer cell growth. PMID: 12121883 Ref: Insulin-like growth factor II and colorectal cancer risk in women. PMID: 12223436 Ref: Effects of genetic blockade of the insulin-like growth factor receptor in human colon cancer cell lines. PMID: 12360481 Ref: Overexpression of the insulin-like growth factor I receptor in human colon carcinomas. PMID: 12412161 Ref: Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. PMID: 12438232 Ref: [Expression and clinical significance of IGF-II mRNA and bcl-2 protein in colorectal adenocarcinomas]. PMID: 12526221 |
Ref: [The expression and imprinting status of insulin-like growth factor 2 gene in colorectal cancer]. PMID: 12579496 Ref: Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. PMID: 12637750 Ref: IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer. PMID: 12845531 Ref: Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. PMID: 12888657 Ref: Inhibition of angiotensin II activity enhanced the antitumor effect of cyclooxygenase-2 inhibitors via insulin-like growth factor I receptor pathway. PMID: 14583467 Ref: trans-10, cis-12 conjugated linoleic acid reduces insulin-like growth factor-II secretion in HT-29 human colon cancer cells. PMID: 14585185 Ref: Interleukin-1beta (IL-1beta) and IL-6 modulate insulin-like growth factor-binding protein (IGFBP) secretion in colon cancer epithelial (Caco-2) cells. PMID: 14656210 |
Ref: Insulin-like growth factor (IGF)-binding protein-4 inhibits colony formation of colorectal cancer cells by IGF-independent mechanisms. PMID: 14996716 Ref: Loss of insulin-like growth factor-II imprinting and the presence of screen-detected colorectal adenomas in women. PMID: 14996863 Ref: Loss of imprinting of insulin growth factor II gene: a potential heritable biomarker for colon neoplasia predisposition. PMID: 15057734 Ref: IGF2 loss of imprinting: a potential heritable risk factor for colorectal cancer. PMID: 15057757 Ref: Oncofetal splice-pattern of the human H19 gene. PMID: 15147959 Ref: Differential expression patterns of the insulin-like growth factor 2 gene in human colorectal cancer. PMID: 15192314 Ref: Allele-specific methylation analysis on upstream promoter region of H19 by methylation-specific PCR with confronting two-pair primers. PMID: 15492815 Ref: Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding. PMID: 15525596 Ref: Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis. PMID: 15585629 Ref: Growth hormone receptor antagonist administration inhibits growth of human colorectal carcinoma in nude mice. PMID: 15736405 |
Ref: Transcriptome analysis of a human colorectal cancer cell line shows molecular targets of insulin-like growth factor-binding protein-4 overexpression. PMID: 15455346 Ref: A case of colorectal carcinoma in adenoma analyzed by a cDNA array. PMID: 15490195 Ref: Regulatory sequences of H19 and IGF2 genes in DNA-based therapy of colorectal rat liver metastases. PMID: 15521051 Ref: The role of the insulin-like growth factor system in colorectal cancer: review of current knowledge. PMID: 15650828 Ref: Overexpression of mature insulin-like growth factor (IGF)-II leads to growth arrest in Caco-2 human colon cancer cells. PMID: 15701574 Ref: Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. PMID: 15731405 Ref: Gene expression profiling of colorectal adenomas and early invasive carcinomas by cDNA array analysis. PMID: 15785755 Ref: Chemoprevention: mouse colon and lung tumor bioassay and modulation of DNA methylation as a biomarker. PMID: 15824018 Ref: Blockade of paracrine supply of insulin-like growth factors using neutralizing antibodies suppresses the liver metastasis of human colorectal cancers. PMID: 15867252 Ref: [Loss of IGF2 imprinting in colorectal cancer]. PMID: 15881352 Ref: IGFBP-6 five years on; not so 'forgotten'? PMID: 15914054 Ref: Interleukin-5 potentiates the growth response of Caco-2 cells to IGF-II: a role in colonic carcinogenesis complicating ulcerative colitis? PMID: 15935984 Ref: Associations between plasma insulin-like growth factor proteins and C-peptide and quality of life in patients with metastatic colorectal cancer. PMID: 15941948 Ref: Leptin, insulin-like growth factor-1, and insulin-like growth factor-2 are mitogens in ApcMin/+ but not Apc+/+ colonic epithelial cell lines. PMID: 16030096 Ref: Positive correlation of insulin-like growth factor-II with proliferating cell index in patients with colorectal neoplasia. PMID: 16030122 Ref: Insulin resistance, apoptosis, and colorectal adenoma risk. PMID: 16172212 |
Ref: Clinicopathological characteristics of colorectal cancers with loss of imprinting of insulin-like growth factor 2. PMID: 16432831 Ref: Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting. PMID: 16488992 Ref: Loss of imprinting in IGF2 in colorectal carcinoma assessed by microdissection. PMID: 16525660 Ref: Antagonists of growth hormone-releasing hormone in oncology. PMID: 16533148 Ref: Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer. PMID: 16603642 Ref: Biology of insulin-like growth factor binding protein-4 and its role in cancer (review). PMID: 16685432 Ref: Computational model for the IGF-II/IGF2r complex that is predictive of mutational and surface plasmon resonance data. PMID: 16741994 Ref: Insulin-like growth factors and cancer: no role in screening. Evidence from the BUPA study and meta-analysis of prospective epidemiological studies. PMID: 16804529 Ref: Inhibition of insulin receptor isoform-A signalling restores sensitivity to gefitinib in previously de novo resistant colon cancer cells. PMID: 16819546 Ref: IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment. PMID: 17118177 |
Ref: Insulin-like growth factors induce apoptosis as well as proliferation in LIM 1215 colon cancer cells. PMID: 16888814 Ref: Isolated isoflavones do not affect the circulating insulin-like growth factor system in men at increased colorectal cancer risk. PMID: 17237315 Ref: Cytoplasmic localization of p27 (cyclin-dependent kinase inhibitor 1B/KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability, and CpG island methylator phenotype. PMID: 17239930 Ref: TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer. PMID: 17270239 Ref: Clinical pharmacodynamic effects of the growth hormone receptor antagonist pegvisomant: implications for cancer therapy. PMID: 17289896 Ref: Loss of imprinting of IGF2 as an epigenetic marker for the risk of human cancer. PMID: 17325430 Ref: Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer. PMID: 17339237 Ref: Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. PMID: 17350669 Ref: Matrix metalloproteinase-7 triggers the matricrine action of insulin-like growth factor-II via proteinase activity on insulin-like growth factor binding protein 2 in the extracellular matrix. PMID: 17359288 Ref: CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma. PMID: 17372756 Ref: Loss of imprinting of insulin-like growth factor II is associated with increased risk of proximal colon cancer. PMID: 17382534 Ref: An epigenetic approach to cancer etiology. PMID: 17464249 Ref: 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high. PMID: 17474983 Ref: Promotion of cancer cell migration: an insulin-like growth factor (IGF)-independent action of IGF-binding protein-6. PMID: 17519236 Ref: Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. PMID: 17591929 Ref: MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. PMID: 17621591 Ref: Targeting of insulin-like growth factor-I receptor with a monoclonal antibody inhibits growth of hepatic metastases from human colon carcinoma in mice. PMID: 17653802 Ref: A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo. PMID: 17671083 Ref: Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer. PMID: 17710160 Ref: Promoter methylation status of multiple genes in uveal melanoma. PMID: 17898258 Ref: Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer. PMID: 17991659 Ref: Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. PMID: 18056424 Ref: IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53. PMID: 18084616 Ref: Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. PMID: 18087038 |
Ref: Assessing the potential usefulness of IGF-related peptides and adiponectin for predicting disease risk. PMID: 17928251 Ref: Increased insulin-like growth factor-1 after oophorectomy in postmenopausal women. PMID: 18054929 Ref: WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 18084250 Ref: Antagonists of growth-hormone-releasing hormone: an emerging new therapy for cancer. PMID: 18084344 Ref: CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci. PMID: 18204436 Ref: Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells. PMID: 18317448 Ref: Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer. PMID: 18365005 Ref: LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 18366060 Ref: PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations. PMID: 18516290 Ref: Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer. PMID: 18541649 Ref: Genetic alterations in colorectal cancers with demethylation of insulin-like growth factor II. PMID: 18619647 Ref: Up-regulation of the hypoxia-inducible factor-1 transcriptional pathway in colorectal carcinomas. PMID: 18619649 Ref: Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype. PMID: 18628431 Ref: Clinicopathological significance of the gene expression of matrix metalloproteinase-7, insulin-like growth factor-1, insulin-like growth factor-2 and insulin-like growth factor-1 receptor in patients with colorectal cancer: insulin-like growth factor-1 re PMID: 18636198 Ref: The H19 locus acts in vivo as a tumor suppressor. PMID: 18719115 Ref: CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels. PMID: 18834226 Ref: No effect of red clover-derived isoflavone intervention on the insulin-like growth factor system in women at increased risk of colorectal cancer. PMID: 18842999 Ref: Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets. PMID: 18940803 Ref: Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype. PMID: 18983468 Ref: Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. PMID: 19002263 Ref: Plasma insulin-like growth factors, insulin-like binding protein-3, and outcome in metastatic colorectal cancer: results from intergroup trial N9741. PMID: 19073970 |
Ref: Expression of insulin-like growth factor system components in colorectal tissue and its relation with serum IGF levels. PMID: 18801683 Ref: CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. PMID: 18832519 Ref: JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype. PMID: 19107235 Ref: Dietary carbohydrate source alters gene expression profile of intestinal epithelium in mice. PMID: 19116885 Ref: Temporal stability and age-related prevalence of loss of imprinting of the insulin-like growth factor-2 gene. PMID: 19242102 Ref: Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice. PMID: 19366832 Ref: SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 19430421 Ref: DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer. PMID: 19470733 Ref: IGF-I, IGF-II, IGFBP2, IGFBP3 and acid-labile subunit (ALS) in colorectal cancer patients before surgery and during one year follow up in relation to age. PMID: 19482725 Ref: Insulin-like growth factor-II methylation status in lymphocyte DNA and colon cancer risk in the Northern Sweden Health and Disease cohort. PMID: 19549920 Ref: Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer. PMID: 19671761 Ref: A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. PMID: 19686742 Ref: Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer. PMID: 19789368 Ref: Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype. PMID: 19825961 Ref: Association of serum retinol and carotenoids with insulin-like growth factors and insulin-like growth factor binding protein-3 among control subjects of a nested case-control study in the Japan Collaborative Cohort Study. PMID: 20553078 Ref: Insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein-3, and risk of colorectal cancer: a nested case-control study in the Japan Collaborative Cohort study. PMID: 20553081 |
Ref: Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer. PMID: 19957330 Ref: Insulin-like growth factors are more effective than progastrin in reversing proapoptotic effects of curcumin: critical role of p38MAPK. PMID: 20133951 Ref: Plasma insulin-like growth factor-binding protein-2 levels as diagnostic and prognostic biomarker of colorectal cancer. PMID: 20157191 Ref: Silencing of the insulin receptor isoform A favors formation of type 1 insulin-like growth factor receptor (IGF-IR) homodimers and enhances ligand-induced IGF-IR activation and viability of human colon carcinoma cells. PMID: 20179263 Ref: PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. PMID: 20200425 Ref: (-)-Epigallocatechin gallate inhibits growth and activation of the VEGF/VEGFR axis in human colorectal cancer cells. PMID: 20346928 Ref: Polymorphisms in methyl-group metabolism genes and risk of sporadic colorectal cancer with relation to the CpG island methylator phenotype. PMID: 20381446 Ref: Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain. PMID: 20479215 Ref: Hypomethylation of the IGF2 DMR in colorectal tumors, detected by bisulfite pyrosequencing, is associated with poor prognosis. PMID: 20682317 Ref: The insulin-like growth factor signaling pathway as a target for treatment of colorectal carcinoma. PMID: 20920993 Ref: Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer. PMID: 21037082 Ref: Evaluation of allelic expression of imprinted genes in adult human blood. PMID: 21042416 Ref: Specific hypomethylated CpGs at the IGF2 locus act as an epigenetic biomarker for familial adenomatous polyposis colorectal cancer. PMID: 22121898 |
Ref: Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review. PMID: 20473920 Ref: The development of composite circulating biomarker models for use in anticancer drug clinical development. PMID: 20549702 Ref: Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression. PMID: 21068132 Ref: MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers. PMID: 21140203 Ref: The "cryptic" mechanism of action of glucagon-like peptide-2. PMID: 21527727 Ref: Detection of viral DNA sequences in sporadic colorectal cancers in relation to CpG island methylation and methylator phenotype. PMID: 21625944 Ref: B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP). PMID: 21738611 Ref: Analysis of expression profile of gene encoding proteins of signal cascades activated by insulin-like growth factors in colorectal cancer. PMID: 21978709 Ref: No Association of Insulin-like Growth Factor Gene Polymorphisms with Survival in Patients with Colorectal Cancer. PMID: 22022297 Ref: C57BL/KsJ-db/db-Apc mice exhibit an increased incidence of intestinal neoplasms. PMID: 22174655 Ref: Effect of maternal and post-weaning folate supply on gene-specific DNA methylation in the small intestine of weaning and adult apc and wild type mice. PMID: 22303319 Ref: IGF-IR in patients with advanced colorectal cancer in correlation with certain clinico-morphological factors: Initial report. PMID: 22848281 |
Ref: Rhabdoid carcinoma of the colon: a distinct entity with a very aggressive behavior: a case report associated with a polyposis coli and review of the literature. PMID: 21791485 Ref: Serum IGF1, IGF2 and IGFBP3 and risk of advanced colorectal adenoma. PMID: 21932422 Ref: CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer. PMID: 22001634 Ref: Multiple antitumor effects of picropodophyllin in colon carcinoma cell lines: clinical implications. PMID: 22159423 Ref: Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells. PMID: 22269172 Ref: Genetic variants, prediagnostic circulating levels of insulin-like growth factors, insulin, and glucose and the risk of colorectal cancer: the Multiethnic Cohort study. PMID: 22354904 Ref: Proteomic analysis of primary colon cancer-associated fibroblasts using the SELDI-ProteinChip platform. PMID: 22374607 Ref: IGF2R genetic variants, circulating IGF2 concentrations and colon cancer risk in African Americans and Whites. PMID: 22377707 Ref: Loss of imprinting of IGF2 correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients. PMID: 22427002 Ref: Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites. PMID: 22565227 Ref: [Epigenomic markers for tumors]. PMID: 22619996 Ref: Comprehensive molecular characterization of human colon and rectal cancer. PMID: 22810696 Ref: Insulin-like growth factor 2 messenger RNA binding protein 3 (IGF2BP3) is a marker of unfavourable prognosis in colorectal cancer. PMID: 22840368 Ref: Recurrent R-spondin fusions in colon cancer. PMID: 22895193 Ref: Insulin-like growth factor 2 gene methylation in peripheral blood mononuclear cells of patients with hepatitis C related cirrhosis or hepatocellular carcinoma. PMID: 22902352 Ref: Gene therapy for colorectal cancer by an oncolytic adenovirus that targets loss of the insulin-like growth factor 2 imprinting system. PMID: 23171475 |
Ref: Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer. PMID: 23034738 Ref: The Igf2as transcript is exported into cytoplasm and associated with polysomes. PMID: 23108799 Ref: Insulin-like growth factor 2 in development and disease: a mini-review. PMID: 23257688 Ref: Circulation insulin-like growth factor peptides and colorectal cancer risk: an updated systematic review and meta-analysis. PMID: 23269623 Ref: Humoral autoimmune response to IGF2 mRNA-binding protein (IMP2/p62) and its tissue-specific expression in colon cancer. PMID: 23421499 Ref: Progastrin-induced secretion of insulin-like growth factor 2 from colonic myofibroblasts stimulates colonic epithelial proliferation in mice. PMID: 23523669 Ref: Gene therapy for cancer through adenovirus vectormediated expression of the Ad5 early region gene 1A based on loss of IGF2 imprinting. PMID: 23900345 Ref: [Expression of molecular markers detected by immunohistochemistry and risk of lymph node metastasis in stage T1 and T2 colorecrectal cancers]. PMID: 23985256 Ref: The association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia. PMID: 24108782 Ref: DNA methylation as an epigenetic biomarker in colorectal cancer. PMID: 24260063 |
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