Primary Site >> Stomach Cancer
Gene >> IGF1R
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Ref: Comparative genomic hybridization of cancer of the gastroesophageal junction: deletion of 14Q31-32.1 discriminates between esophageal (Barrett's) and gastric cardia adenocarcinomas. PMID: 9973227 |
Ref: IQGAP1, a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 and 40A. PMID: 11289714 |
Ref: Gastric cancer: the role of insulin-like growth factor 2 (IGF 2) and its receptors (IGF 1R and M6-P/IGF 2R). PMID: 14595755 |
Ref: Impact of PTEN on the expression of insulin-like growth factors (IGFs) and IGF-binding proteins in human gastric adenocarcinoma cells. PMID: 15809062 Ref: Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature. PMID: 15838387 |
Ref: Gastric cancer in the era of molecularly targeted agents: current drug development strategies. PMID: 19363621 Ref: [Expression and significance of IGF-1R and VEGF in gastric carcinoma]. PMID: 19500509 |
Ref: Expression and prognostic significance of CEACAM6, ITGB1, and CYR61 in peripheral blood of patients with gastric cancer. PMID: 21618249 |
Ref: Evaluation of the antitumor effects and mechanisms of PF00299804, a pan-HER inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancer. PMID: 22135232 |
Ref: MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. PMID: 22614005 Ref: A novel proteomics-based clinical diagnostics technology identifies heterogeneity in activated signaling pathways in gastric cancers. PMID: 23372746 Ref: Met, IGF1R, and other new targets in upper GI malignancies. PMID: 23873272 |
Ref: Targeting receptor tyrosine kinases in gastric cancer. PMID: 24782606 Ref: MicroRNA-206 suppresses gastric cancer cell growth and metastasis. PMID: 24855559 Ref: miR-1271 regulates cisplatin resistance of human gastric cancer cell lines by targeting IGF1R, IRS1, mTOR, and BCL2. PMID: 24875127 Ref: MiR-503 regulates cisplatin resistance of human gastric cancer cell lines by targeting IGF1R and BCL2. PMID: 24931256 Ref: Functional genetic approach identifies MET, HER3, IGF1R, INSR pathways as determinants of lapatinib unresponsiveness in HER2-positive gastric cancer. PMID: 24973425 Ref: Expression of insulin-like growth factor receptor type 1 correlate with lymphatic metastases in human gastric cancer. PMID: 25119174 Ref: Phosphorylated insulin-like growth factor-1 receptor expression predicts poor prognosis of Chinese patients with gastric cancer. PMID: 25348345 Ref: Immunohistochemical analysis of RTKs expression identified HER3 as a prognostic indicator of gastric cancer. PMID: 25455899 |
Ref: Insulin-like growth factor pathway aberrations and gastric cancer; evaluation of prognostic significance and assessment of therapeutic potentials. PMID: 25487446 Ref: Involvement of miR-143 in cisplatin resistance of gastric cancer cells via targeting IGF1R and BCL2. PMID: 25492481 Ref: Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R. PMID: 25780292 Ref: Development of trastuzumab-resistant human gastric carcinoma cell lines and mechanisms of drug resistance. PMID: 26108989 Ref: [Association of prognosis with insulin-like growth factor receptor type I expression in gastric cancer patients: a meta-analysis]. PMID: 26499155 |
Ref: Relationship between insulin-like growth factor axis gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX. PMID: 27144430 Ref: Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo. PMID: 27277844 Ref: Importance of the type I insulin-like growth factor receptor in HER2, FGFR2 and MET-unamplified gastric cancer with and without Ras pathway activation. PMID: 27437872 Ref: Anti-proliferative role and prognostic implication of miR-141 in gastric cancer. PMID: 27648145 Ref: miR-494 inhibits invasion and proliferation of gastric cancer by targeting IGF-1R. PMID: 27735036 Ref: Letter to the Editor - miR-494 inhibits invasion and proliferation of gastric cancer by targeting IGF-1R. PMID: 27874961 |
Ref: Impact of insulin-like growth factor-1 receptor and amphiregulin expression on survival in patients with stage II/III gastric cancer enrolled in the Adjuvant Chemotherapy Trial of S-1 for Gastric Cancer. PMID: 26884344 Ref: Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer. PMID: 27891760 Ref: IGF1/IGF1R/STAT3 signaling-inducible IFITM2 promotes gastric cancer growth and metastasis. PMID: 28223169 Ref: Formation of the IGF1R/CAV1/SRC tri-complex antagonizes TRAIL-induced apoptosis in gastric cancer cells. PMID: 28403518 Ref: MicroRNA455 is downregulated in gastric cancer and inhibits cell proliferation, migration and invasion via targeting insulinlike growth factor 1 receptor. PMID: 28714005 Ref: MicroRNA-302b-3p Suppresses Cell Proliferation Through AKT Pathway by Targeting IGF-1R in Human Gastric Cancer. PMID: 28743112 Ref: The crucial role of SRPK1 in IGF-1-induced EMT of human gastric cancer. PMID: 29069776 Ref: [Expression and Prognostic Significance of P-IGF1R in Gastric Cancer]. PMID: 29262508 |
Ref: Gastric poorly cohesive carcinoma: a correlative study of mutational signatures and prognostic significance based on histopathological subtypes. PMID: 28873240 Ref: Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype. PMID: 29725014 Ref: IGF-1-induced MMP-11 expression promotes the proliferation and invasion of gastric cancer cells through the JAK1/STAT3 signaling pathway. PMID: 29731870 Ref: miR-598 acts as a tumor suppressor in human gastric cancer by targeting IGF-1R. PMID: 29844688 Ref: Identification of Potential Biomarkers Involved in Gastric Cancer Through Integrated Analysis of Non-Coding RNA Associated Competing Endogenous RNAs Network. PMID: 30336538 Ref: NUCKS1 promotes gastric cancer cell aggressiveness by upregulating IGF-1R and subsequently activating the PI3K/Akt/mTOR signaling pathway. PMID: 30371738 |