Primary Site >> Colorectal Cancer
Gene >> IGF1
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Ref: Insulin receptor proliferation: a mechanism for tumor-associated hypoglycemia. PMID: 3528210 Ref: Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas. PMID: 3779638 |
Ref: Presence of somatomedin receptors on primary human breast and colon carcinomas. PMID: 2961436 Ref: Simultaneous production of IGF-I and EGF competing growth factors by HT-29 human colon cancer line. PMID: 3500134 |
Ref: Insulin and insulin-like growth factor 1 stimulate proliferation of metastatic variants of colon carcinoma 26. PMID: 2540132 Ref: Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer. PMID: 2747657 |
Ref: Production of insulin-like growth factor II (IGF-II) and different forms of IGF-binding proteins by HT-29 human colon carcinoma cell line. PMID: 1694180 Ref: Treatment of patients with metastatic pancreatic and gastrointestinal tumours with the somatostatin analogue Sandostatin: a phase II study including endocrine effects. PMID: 1977468 Ref: Detection of colonic growth factors using a human colonic carcinoma cell line (LIM1215). PMID: 2228314 Ref: Growth-regulatory factors for normal, premalignant, and malignant human cells in vitro. PMID: 2404378 |
Ref: Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein. PMID: 1709585 Ref: Tumor IGF-II content in a patient with a colon adenocarcinoma correlates with abnormal expression of the gene. PMID: 1713573 Ref: Insulin-like growth factor I rapidly induces tyrosine phosphorylation of a Mr 150,000 and a Mr 160,000 protein in highly metastatic mouse colon carcinoma 26 NL-17 cells. PMID: 1718586 Ref: Type-II insulin-like growth-factor receptor in conditioned medium from HT-29 human colon carcinoma cell line. PMID: 1848538 |
Ref: des-(1-3)-IGF-I, an insulin-like growth factor analog used to mimic a potential IGF-II autocrine loop, promotes the differentiation of human colon-carcinoma cells. PMID: 1281142 Ref: Insulin like growth factor I is an autocrine regulator of human colon cancer cell differentiation and growth. PMID: 1311629 Ref: Characterization of insulinlike growth factor I receptors in human colon cancer. PMID: 1312970 Ref: Expression of type I, but not type II insulin-like growth factor receptor on both undifferentiated and differentiated HT29 human colon carcinoma cell line. PMID: 1322432 Ref: Growth regulation and co-stimulation of human colorectal cancer cell lines by insulin-like growth factor I, II and transforming growth factor alpha. PMID: 1558785 |
Ref: Monocyte-conditioned media possess a novel factor which increases motility of cancer cells. PMID: 8428796 |
Ref: Alterations in serum levels of insulin-like growth factors and insulin-like growth-factor-binding proteins in patients with colorectal cancer. PMID: 7514152 Ref: Expression of IGF-II and IGF-binding proteins by colon cancer cells in relation to growth response to IGFs. PMID: 7524348 Ref: Episomal expression of sense and antisense insulin-like growth factor (IGF)-binding protein-4 complementary DNA alters the mitogenic response of a human colon cancer cell line (HT-29) by mechanisms that are independent of and dependent upon IGF-I. PMID: 7527300 Ref: Surface distribution of the EGF receptor during differentiation of the human colon carcinoma cell line HT29-D4. PMID: 7815389 Ref: Blockade of the insulin-like growth-factor-I receptor inhibits growth of human colorectal cancer cells: evidence of a functional IGF-II-mediated autocrine loop. PMID: 8050827 Ref: Human colon carcinoma cells (CaCo-2) synthesize IGF-II and express IGF-I receptors and IGF-II/M6P receptors. PMID: 9397946 |
Ref: Constitutive or inducible overexpression of the IGF-2 gene in cells of a human colon carcinoma cell line. PMID: 7531153 Ref: Type I insulin-like growth factor receptors in human colorectal cancer. PMID: 7695979 Ref: Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. PMID: 7706497 Ref: IGF-2 autocrine stimulation in tumorigenic clones of a human colon-carcinoma cell line. PMID: 7759165 Ref: Expression of growth factor receptor-encoded mRNA by colonic epithelial cells is altered in inflammatory bowel disease. PMID: 7895532 Ref: Activation of the E-cadherin/catenin complex in human MCF-7 breast cancer cells by all-trans-retinoic acid. PMID: 8519658 |
Ref: The lack of an effect by insulin or insulin-like growth factor-1 in attenuating colon-2-mediated cancer cachexia. PMID: 8616811 Ref: Growth inhibition signalled through the interleukin-4/interleukin-13 receptor complex is associated with tyrosine phosphorylation of insulin receptor substrate-1. PMID: 8645156 Ref: A dose-finding study of lanreotide (a somatostatin analog) in patients with colorectal carcinoma. PMID: 8646723 Ref: Mevalonic acid is limiting for N-linked glycosylation and translocation of the insulin-like growth factor-1 receptor to the cell surface. Evidence for a new link between 3-hydroxy-3-methylglutaryl-coenzyme a reductase and cell growth. PMID: 8663239 Ref: Cytokine regulation of ezrin expression in the human colon cancer cell line HT29. PMID: 8687142 Ref: The role of somatostatin analogues in the treatment of gastro-enteropancreatic endocrine tumours. PMID: 8813475 Ref: Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma. PMID: 8910616 Ref: Insulin receptor tyrosine kinase activity in colon carcinoma. PMID: 9222417 |
Ref: Insulin-like growth factors and their binding proteins in human colonocytes: preferential degradation of insulin-like growth factor binding protein 2 in colonic cancers. PMID: 9218734 Ref: A rare case of gastric cancer in an acromegalic patient. PMID: 9250902 Ref: Inhibition of tumor cell kinetics and serum insulin growth factor I levels by octreotide in colorectal cancer patients. PMID: 9287967 Ref: Acromegaly, colonic polyps and carcinoma. PMID: 9302367 Ref: Surface-bound plasmin induces selective proteolysis of insulin-like-growth-factor (IGF)-binding protein-4 (IGFBP-4) and promotes autocrine IGF-II bio-availability in human colon-carcinoma cells. PMID: 9311602 Ref: Insulin-like growth factor binding proteins as mediators of IGF-I effects on colon cancer cell proliferation. PMID: 9386991 Ref: Paracrine interactions between mesothelial and colon-carcinoma cells in a rat model. PMID: 9399671 Ref: Diabetes mellitus and colorectal cancer risk. PMID: 9419395 |
Ref: Insulin-like growth factor-I and II receptor expression in rat colon mucosa are affected by dietary lipid intake. PMID: 9446837 Ref: Insulin-like growth factor-I promotes multidrug resistance in MCLM colon cancer cells. PMID: 9525472 Ref: Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. PMID: 9731515 Ref: Integrin ligation and PKC activation are required for migration of colon carcinoma cells. PMID: 9739085 Ref: Insulin-like growth factor-binding protein-2 inhibits proliferation of human embryonic kidney fibroblasts and of IGF-responsive colon carcinoma cell lines. PMID: 9742949 Ref: Sequence alterations of insulin-like growth factor binding protein 3 in neoplastic and normal gastrointestinal tissues. PMID: 9809981 Ref: Role of insulin-like growth factor-I (IGF-I) receptor, IGF-I, and IGF binding protein-2 in human colorectal cancers. PMID: 10985759 |
Ref: Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. PMID: 10203281 Ref: Inhibition of epidermal-growth-factor-receptor-dependent signalling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro. PMID: 10394957 Ref: IGF-I and IGF-II in relation to colorectal cancer. PMID: 10449601 Ref: Expression of insulin-like growth factor-1 receptor in human colorectal cancer. PMID: 10534157 Ref: Antagonistic Analogs of Growth Hormone-releasing Hormone: New Potential Antitumor Agents. PMID: 10542394 Ref: Re: Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. PMID: 10580038 Ref: Insulin-like growth factor-I and binding protein-3 and risk of cancer. PMID: 10592442 Ref: IGFs and human cancer: implications regarding the risk of growth hormone therapy. PMID: 10592443 Ref: Determination of insulin-like growth factor-I in the monitoring of growth hormone treatment with respect to efficacy of treatment and side effects: should potential risks of cardiovascular disease and cancer be considered? PMID: 10592459 Ref: Vegan proteins may reduce risk of cancer, obesity, and cardiovascular disease by promoting increased glucagon activity. PMID: 10687887 Ref: Nutritional factors in human cancers. PMID: 10736613 |
Ref: Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. PMID: 10699960 Ref: Chemoprevention of breast cancer: the Italian experience. PMID: 10762020 Ref: One year growth hormone replacement therapy does not alter colonic epithelial cell proliferation in growth hormone deficient adults. PMID: 10762288 Ref: Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways. PMID: 10766192 Ref: Enhancement of immunogenicity of tumor cells by cotransfection with genes encoding antisense insulin-like growth factor-1 and B7.1 molecules. PMID: 10766352 Ref: A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women. PMID: 10794477 Ref: Antagonists of growth hormone-releasing hormone (GH-RH) inhibit IGF-II production and growth of HT-29 human colon cancers. PMID: 10817510 Ref: Incidence of malignant tumors in patients with acromegaly. PMID: 10890185 Ref: Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. PMID: 10910078 Ref: A prospective study of plasma levels of insulin-like growth factor I (IGF-I) and IGF-binding protein-3, and colorectal cancer risk among men. PMID: 10984282 Ref: Circulating insulin-like growth factor II and colorectal adenomas. PMID: 10999841 Ref: The prevalence and characteristics of colorectal neoplasia in acromegaly. PMID: 10999843 Ref: Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women. PMID: 11018095 Ref: Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin. PMID: 11035789 Ref: Insulin-like growth factor I receptor antagonism augments response to chemoradiation therapy in colon cancer cells. PMID: 11038295 Ref: Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer. PMID: 11044360 Ref: More about: prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. PMID: 11106691 Ref: RESPONSE: more about: prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3 PMID: 11106693 Ref: RESPONSE: more about: prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF- binding protein-3 PMID: 11106694 Ref: IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in Caco-2 human colon carcinoma cells. PMID: 11114729 Ref: Does the GH-IGF axis play a role in cancer pathogenesis? PMID: 11161960 |
Ref: High-risk colorectal adenomas and serum insulin-like growth factors. PMID: 11136321 Ref: Incidence of a second tumor in hypopituitary patients operated for pituitary tumors. PMID: 11158027 Ref: Effect of inflammatory cytokines and growth factors on tumour cell adhesion to the peritoneum. PMID: 11276014 Ref: Insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced but not basal proliferation and adhesion of LIM 1215 colon cancer cells. PMID: 11306178 Ref: Energy balance and cancer: the role of insulin and insulin-like growth factor-I. PMID: 11310428 Ref: Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody. PMID: 11313939 Ref: Increased levels of insulin-like growth factor binding protein-2 in sera and tumours from patients with colonic neoplasia with and without acromegaly. PMID: 11318786 Ref: Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions. PMID: 11402025 Ref: Androgenic progestins amplify the breast cancer risk associated with hormone replacement therapy by boosting IGF-I activity. PMID: 11425289 Ref: Protein shuttles, IGF-I and colorectal cancer. PMID: 11427994 Ref: The interaction of insulin-like growth factor-I with the N-terminal domain of IGFBP-5. PMID: 11447105 Ref: Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men. PMID: 11535708 Ref: The growth hormone-insulin-like growth factor-I axis and colorectal cancer. PMID: 11597519 Ref: Clinical features and therapeutic outcomes of 65 patients with acromegaly at Tokyo Women's Medical University. PMID: 11688841 Ref: IGF-1, IGF-2 and IGFBP-3 in prediagnostic serum: association with colorectal cancer in a cohort of Chinese men in Shanghai. PMID: 11742490 Ref: Nutrition and health: epidemiology of diet, cancer and cardiovascular disease in Italy. PMID: 11894740 |
Ref: Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. PMID: 11861378 Ref: Association of a common polymorphism in the human GH1 gene with colorectal neoplasia. PMID: 11904318 Ref: Insulin-like growth factor-I has a biphasic effect on colon carcinoma cells through transient inactivation of forkhead1, initially mitogenic, then mediating growth arrest and differentiation. PMID: 11920634 Ref: Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden. PMID: 11950809 Ref: Activation of the TGFalpha autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells. PMID: 11973637 Ref: Prevention of cytokine-induced apoptosis by insulin-like growth factor-I is independent of cell adhesion molecules in HT29-D4 colon carcinoma cells-evidence for a NF-kappaB-dependent survival mechanism. PMID: 12058282 Ref: Decreased production of insulin-like growth factor-binding protein (IGFBP)-6 by transfection of colon cancer cells with an antisense IGFBP-6 cDNA construct leads to stimulation of cell proliferation. PMID: 12084030 Ref: Effects of weight control and physical activity in cancer prevention: role of endogenous hormone metabolism. PMID: 12095952 Ref: Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. PMID: 12096082 Ref: Regulation of TRAIL expression by the phosphatidylinositol 3-kinase/Akt/GSK-3 pathway in human colon cancer cells. PMID: 12140294 Ref: Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959-85: a cohort study. PMID: 12147369 Ref: Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. PMID: 12149254 Ref: Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma. PMID: 12189136 Ref: Local expression of insulin-like growth factor-I affects angiogenesis in colorectal cancer. PMID: 12218293 Ref: Insulin-like growth factor II and colorectal cancer risk in women. PMID: 12223436 Ref: Effects of genetic blockade of the insulin-like growth factor receptor in human colon cancer cell lines. PMID: 12360481 Ref: Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer. PMID: 12374697 Ref: Impact of insulin-like growth factor receptor-I function on angiogenesis, growth, and metastasis of colon cancer. PMID: 12379772 Ref: Overexpression of the insulin-like growth factor I receptor in human colon carcinomas. PMID: 12412161 Ref: Extracellular thiol/disulfide redox state affects proliferation rate in a human colon carcinoma (Caco2) cell line. PMID: 12446207 Ref: Nutrition, energy balance and colon cancer risk: the role of insulin and insulin-like growth factor-I. PMID: 12484189 Ref: Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-l-cysteine. PMID: 12485928 Ref: Modifiable risk factors for colon cancer. PMID: 12489270 Ref: Effects of a 9-month strength training intervention on insulin, insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and IGFBP-3 in 30-50-year-old women. PMID: 12496050 Ref: Mono- or dual-phosphorylation of akt kinase is regulated by distinct receptors that involve the common insulin receptor substrate. PMID: 12503617 Ref: Oncological complications of excess GH in acromegaly. PMID: 12638722 |
Ref: Byssochlamysol, a new antitumor steroid against IGF-1-dependent cells from Byssochlamys nivea. I. Taxonomy, fermentation, isolation and biological activity. PMID: 12670042 Ref: Insulin resistance and its contribution to colon carcinogenesis. PMID: 12671184 Ref: Body mass index and colon cancer: an evaluation of the modifying effects of estrogen (United States). PMID: 12708728 Ref: Acromegaly due to ectopic secretion of GHRH by bronchial carcinoid in a patient with empty sella. PMID: 12739745 Ref: Glycemic load, carbohydrate intake, and risk of colorectal cancer in women: a prospective cohort study. PMID: 12813175 Ref: Insulin-like growth factor 1 receptor activates c-SRC and modifies transformation and motility of colon cancer in vitro. PMID: 12820418 Ref: IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer. PMID: 12845531 Ref: Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. PMID: 12888657 Ref: Serum insulin-like growth factor I and subsequent risk of colorectal cancer among Japanese-American men. PMID: 12936897 Ref: Hyperinsulinemia may boost both hematocrit and iron absorption by up-regulating activity of hypoxia-inducible factor-1alpha. PMID: 14592787 Ref: Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway. PMID: 14633695 Ref: Interleukin-1beta (IL-1beta) and IL-6 modulate insulin-like growth factor-binding protein (IGFBP) secretion in colon cancer epithelial (Caco-2) cells. PMID: 14656210 Ref: Acromegaly and colorectal cancer: a comprehensive review of epidemiology, biological mechanisms, and clinical implications. PMID: 14710350 Ref: Inhibition of the biologic response to insulin-like growth factor I in MCF-7 breast cancer cells by a new monoclonal antibody to the insulin-like growth factor-I receptor. The importance of receptor down-regulation. PMID: 14710368 Ref: Increased fasting serum levels of growth hormone and gastrin in patients with gastric and large bowel cancer. PMID: 15244195 |
Ref: Matrix metalloproteinase-7 facilitates insulin-like growth factor bioavailability through its proteinase activity on insulin-like growth factor binding protein 3. PMID: 14744783 Ref: Alpha-catenin is required for IGF-I-induced cellular migration but not invasion in human colonic cancer cells. PMID: 14961074 Ref: Insulin-like growth factor (IGF)-binding protein-4 inhibits colony formation of colorectal cancer cells by IGF-independent mechanisms. PMID: 14996716 Ref: Aspirin, NSAIDs, and colorectal cancer: possible involvement in an insulin-related pathway. PMID: 15066917 Ref: A prospective study of plasma C-peptide and colorectal cancer risk in men. PMID: 15069117 Ref: Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53. PMID: 15131018 Ref: Cancer risk following growth hormone use in childhood: implications for current practice. PMID: 15144231 Ref: Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer. PMID: 15247132 Ref: Dietary and lifestyle correlates of plasma insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3): the multiethnic cohort. PMID: 15342444 Ref: Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding. PMID: 15525596 Ref: Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence. PMID: 15562834 Ref: Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis. PMID: 15585629 Ref: Expression of the insulin-like growth factor-I receptor and proapoptotic Bax and Bak proteins in human colorectal cancer. PMID: 15659820 Ref: Growth hormone receptor antagonist administration inhibits growth of human colorectal carcinoma in nude mice. PMID: 15736405 Ref: Acromegaly and cancer. PMID: 15761242 |
Ref: Colonoscopic screening and follow-up in patients with acromegaly: a multicenter study in Italy. PMID: 15507515 Ref: Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling. PMID: 15592498 Ref: The role of the insulin-like growth factor system in colorectal cancer: review of current knowledge. PMID: 15650828 Ref: A new single nucleotide polymorphism in the insulin-like growth factor I regulatory region associates with colorectal cancer risk in singapore chinese. PMID: 15668488 Ref: Energy balance, insulin-related genes and risk of colon and rectal cancer. PMID: 15688407 Ref: Activated Ras enhances insulin-like growth factor I induction of vascular endothelial growth factor in prostate epithelial cells. PMID: 15781617 Ref: Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care--correlations with food intake, metabolism, exercise capacity, and hormones. PMID: 15822132 Ref: A prospective study of C-peptide, insulin-like growth factor-I, insulin-like growth factor binding protein-1, and the risk of colorectal cancer in women. PMID: 15824155 Ref: Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor. PMID: 15849510 Ref: Blockade of paracrine supply of insulin-like growth factors using neutralizing antibodies suppresses the liver metastasis of human colorectal cancers. PMID: 15867252 Ref: Insulin-like growth factor polymorphisms and colorectal cancer risk. PMID: 15894673 Ref: Association of an exon 1 polymorphism in the IGFBP3 gene with circulating IGFBP-3 levels and colorectal cancer risk: the multiethnic cohort study. PMID: 15894694 Ref: [Study on the relations between serum insulin-like growth factor-1, insulin-like growth factor binding protein-3 and colorectal cancer: a meta-analysis]. PMID: 15921617 Ref: Variation in plasma insulin-like growth factor-1 and insulin-like growth factor binding protein-3: genetic factors. PMID: 15941947 Ref: Associations between plasma insulin-like growth factor proteins and C-peptide and quality of life in patients with metastatic colorectal cancer. PMID: 15941948 Ref: ERbeta is a potent inhibitor of cell proliferation in the HCT8 human colon cancer cell line through regulation of cell cycle components. PMID: 15947116 Ref: Change of the growth hormone-insulin-like growth factor-I axis in patients with gastrointestinal cancer: related to tumour type and nutritional status. PMID: 16022754 Ref: Leptin, insulin-like growth factor-1, and insulin-like growth factor-2 are mitogens in ApcMin/+ but not Apc+/+ colonic epithelial cell lines. PMID: 16030096 Ref: ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma. PMID: 16044163 Ref: EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells. PMID: 16053920 Ref: Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps. PMID: 16083703 Ref: Studies involving the GH-IGF axis: Lessons from IGF-I and IGF-I receptor gene targeting mouse models. PMID: 16114270 Ref: Membrane rafts segregate pro- from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily. PMID: 16127155 Ref: Variation in plasma insulin-like growth factor-1 and insulin-like growth factor binding protein-3: personal and lifestyle factors (United States). PMID: 16132801 Ref: Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA. PMID: 16150444 Ref: Insulin resistance, apoptosis, and colorectal adenoma risk. PMID: 16172212 Ref: Differential expression of IGF-binding protein-3 in normal and malignant colon and its influence on apoptosis. PMID: 16322329 Ref: Genistein inhibits insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells: a possible mechanism of the growth inhibitory effect of Genistein. PMID: 16379552 |
Ref: Physical activity, insulin-like growth factor 1, insulin-like growth factor binding protein 3, and survival from colorectal cancer. PMID: 16299029 Ref: Hyperinsulinemia, but not other factors associated with insulin resistance, acutely enhances colorectal epithelial proliferation in vivo. PMID: 16410309 Ref: P53 correlates positively with VEGF in preoperative sera of colorectal cancer patients. PMID: 16416012 Ref: IGF1 gene polymorphism and risk for hereditary nonpolyposis colorectal cancer. PMID: 16418517 Ref: Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer. PMID: 16448675 Ref: NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling. PMID: 16488889 Ref: PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States). PMID: 16489531 Ref: Antagonists of growth hormone-releasing hormone in oncology. PMID: 16533148 Ref: Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences. PMID: 16675592 Ref: Biology of insulin-like growth factor binding protein-4 and its role in cancer (review). PMID: 16685432 Ref: Fas-associated phosphatase-1 promotes Fas-mediated apoptosis in human colon cancer cells: novel function of FAP-1. PMID: 16706817 Ref: Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner. PMID: 16728583 Ref: Computational model for the IGF-II/IGF2r complex that is predictive of mutational and surface plasmon resonance data. PMID: 16741994 Ref: Insulin-like growth factors and cancer: no role in screening. Evidence from the BUPA study and meta-analysis of prospective epidemiological studies. PMID: 16804529 Ref: Carbohydrate digestibility predicts colon carcinogenesis in azoxymethane-treated rats. PMID: 17044771 Ref: Cancers associated with acromegaly. PMID: 17047386 Ref: [Colorectal carcinoma screening in patients with type 2 diabetes mellitus]. PMID: 17115358 Ref: Insulin-like growth factor-I receptor correlates with connexin 26 and Bcl-xL expression in human colorectal cancer. PMID: 17384270 |
Ref: Isolated isoflavones do not affect the circulating insulin-like growth factor system in men at increased colorectal cancer risk. PMID: 17237315 Ref: Plasma C-peptide, insulin-like growth factor-I, insulin-like growth factor binding proteins and risk of colorectal cancer in a nested case-control study: the Japan public health center-based prospective study. PMID: 17266031 Ref: Clinical pharmacodynamic effects of the growth hormone receptor antagonist pegvisomant: implications for cancer therapy. PMID: 17289896 Ref: Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition. PMID: 17372899 Ref: ATP non-competitive IGF-1 receptor kinase inhibitors as lead anti-neoplastic and anti-papilloma agents. PMID: 17376430 Ref: Insulin-like growth factor-I and risk of high-grade cervical intraepithelial neoplasia. PMID: 17416762 Ref: Gestational programming of offspring obesity: a potential contributor to Alzheimer's disease. PMID: 17430249 Ref: Insulinlike growth factor I receptor and estrogen receptor beta expressions are inversely correlated in colorectal neoplasms and affected by the insulin resistance syndrome. PMID: 17442373 Ref: Metabolic syndrome and gastrointestinal diseases. PMID: 17464454 Ref: Promotion of cancer cell migration: an insulin-like growth factor (IGF)-independent action of IGF-binding protein-6. PMID: 17519236 Ref: Tomato lycopene extract supplementation decreases insulin-like growth factor-I levels in colon cancer patients. PMID: 17554202 Ref: Role of insulin-like growth factor-1 in colon cancerogenesis: a case-control study. PMID: 17560457 Ref: Dietary carbohydrate, glycemic index, and glycemic load and the risk of colorectal cancer in the BCDDP cohort. PMID: 17605083 Ref: PGE2 inhibits apoptosis in human adenocarcinoma Caco-2 cell line through Ras-PI3K association and cAMP-dependent kinase A activation. PMID: 17640974 Ref: Targeting of insulin-like growth factor-I receptor with a monoclonal antibody inhibits growth of hepatic metastases from human colon carcinoma in mice. PMID: 17653802 Ref: A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo. PMID: 17671083 Ref: [Serum concentration of insulin, C-peptide and insulin-like growth factor I in patients with colon adenomas and colorectal cancer]. PMID: 17679371 Ref: Increased apoptosis and decreased proliferation of colorectal cancer cells using insulin-like growth factor binding protein-4 gene delivered locally by gene transfer. PMID: 17824980 Ref: Fetal programming of colon cancer in adult rats: correlations with altered neonatal growth trajectory, circulating IGF-I and IGF binding proteins, and testosterone. PMID: 17911399 Ref: Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer. PMID: 17991659 Ref: Polymorphisms in the insulin like growth factor 1 and IGF binding protein 3 genes and risk of colorectal cancer. PMID: 18031946 Ref: Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. PMID: 18087038 Ref: IGF-1 Gene Expression in Rat Colonic Mucosa After Different Exercise Volumes. PMID: 24149475 |
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