Primary Site >> Colorectal Cancer
Gene >> IDH1
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Ref: Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production. PMID: 21996744 Ref: COLD-PCR enrichment of rare cancer mutations prior to targeted amplicon resequencing. PMID: 22194627 Ref: Targeting cancer metabolism. PMID: 23071355 |
Ref: Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas. PMID: 23204232 Ref: The CpG island methylator phenotype: what's in a name? PMID: 23801749 |
Ref: Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer. PMID: 24887488 Ref: Isocitrate dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype. PMID: 25496513 |
Ref: Mathematical analysis predicts imbalanced IDH1/2 expression associates with 2-HG-inactivating beta-oxygenation pathway in colorectal cancer. PMID: 25586680 Ref: Novel molecular insights from routine genotyping of colorectal carcinomas. PMID: 25683705 Ref: Diagnostic yield of targeted next generation sequencing in various cancer types: an information-theoretic approach. PMID: 26227479 Ref: Metformin prevents DMH-induced colorectal cancer in diabetic rats by reversing the warburg effect. PMID: 26376762 Ref: Evidence that 2-hydroxyglutarate is not readily metabolized in colorectal carcinoma cells. PMID: 26629338 |
Ref: Absence of IDH mutation in colorectal cancers with microsatellite instability. PMID: 26987944 Ref: Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease. PMID: 27063727 Ref: Decreased expression of IDH1-R132H correlates with poor survival in gastrointestinal cancer. PMID: 27655638 Ref: Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer. PMID: 27824159 Ref: Personalized oncogenomics in the management of gastrointestinal carcinomas-early experiences from a pilot study. PMID: 28050146 |
Ref: Implementation and utilization of the molecular tumor board to guide precision medicine. PMID: 28915716 |
Ref: Butyrate Inhibits Indices of Colorectal Carcinogenesis via Enhancing alpha-Ketoglutarate-Dependent DNA Demethylation of Mismatch Repair Genes. PMID: 29577594 Ref: Distinct Histopathologic and Molecular Alterations in Inflammatory Bowel Disease-Associated Intestinal Adenocarcinoma: c-MYC Amplification is Common and Associated with Mucinous/Signet Ring Cell Differentiation. PMID: 29788391 Ref: Supra-physiological concentration of glyoxylate inhibits proliferation of human colon cancer cells through oxidative stress. PMID: 29852189 Ref: Correlation of IDH1 and B7H3 expression with prognosis of CRC patients. PMID: 29871819 Ref: IDH1-mutant cancer cells are sensitive to cisplatin and an IDH1-mutant inhibitor counteracts this sensitivity. PMID: 29879375 Ref: LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/beta-catenin pathway and predicts poor survival of glioma patients. PMID: 30208924 |