Primary Site >> Colorectal Cancer
Gene >> HUWE1
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Ref: Over-expression of human UREB1 in colorectal cancer: HECT domain of human UREB1 inhibits the activity of tumor suppressor p53 protein. PMID: 15567145 |
Ref: Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase. PMID: 25253726 |
Ref: Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. PMID: 27184401 Ref: Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation via Mule in colorectal cancer cells. PMID: 27517746 |
Ref: HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation. PMID: 28003334 Ref: Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway. PMID: 28107519 Ref: E3 ubiquitin ligase Mule targets beta-catenin under conditions of hyperactive Wnt signaling. PMID: 28137882 |