Primary Site >> Colorectal Cancer
Gene >> HSPA5
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Ref: Expression of the 100-kda glucose-regulated protein (GRP100/endoplasmin) is associated with tumorigenicity in a model of rat colon adenocarcinoma. PMID: 8314328 |
Ref: Heat shock proteins are differentially expressed in human gastrointestinal cancers. PMID: 8528482 Ref: Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II. PMID: 8704275 |
Ref: A novel mutant from apoptosis-resistant colon cancer HT-29 cells showing hyper-apoptotic response to hypoxia, low glucose and cisplatin. PMID: 9914786 |
Ref: Increased sensitivity of human colon cancer cells to DNA cross-linking agents after GRP78 up-regulation. PMID: 10198218 |
Ref: Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate. PMID: 12507930 |
Ref: Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis. PMID: 12606154 |
Ref: Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells. PMID: 15142672 Ref: Effective photoimmunotherapy of murine colon carcinoma induced by the combination of photodynamic therapy and dendritic cells. PMID: 15240542 Ref: Effect on tumor cells of blocking survival response to glucose deprivation. PMID: 15339968 |
Ref: Expression of stress response protein glucose regulated protein-78 mediated by c-Myb. PMID: 15778089 |
Ref: Overexpression of glucose-regulated protein 78 in colon cancer. PMID: 16182273 Ref: Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells. PMID: 16524888 Ref: Selective cytotoxic activity of valinomycin against HT-29 Human colon carcinoma cells via down-regulation of GRP78. PMID: 16595926 |
Ref: Glucose-deprived HT-29 human colon carcinoma cells are sensitive to verrucosidin as a GRP78 down-regulator. PMID: 17161515 Ref: Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. PMID: 17283163 Ref: [Differential expression of secretagogin and glucose-related protein 78 in colorectal carcinoma: a proteome study]. PMID: 17493385 |
Ref: Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator. PMID: 17941090 Ref: 15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription. PMID: 18852146 |
Ref: Extended liver resection after preoperative chemotherapy: influence on regeneration and endoplasmic reticulum stress response. PMID: 18688639 Ref: Tosylcyclonovobiocic acids promote cleavage of the hsp90-associated cochaperone p23. PMID: 19118525 Ref: High Ki67, Bax, and thymidylate synthase expression well correlates with response to chemoradiation therapy in locally advanced rectal cancers: proposal of a logistic model for prediction. PMID: 19491899 Ref: Inhibition of MEK sensitizes paclitaxel-induced apoptosis of human colorectal cancer cells by downregulation of GRP78. PMID: 19521235 Ref: Thioredoxin reductase 1 ablation sensitizes colon cancer cells to methylseleninate-mediated cytotoxicity. PMID: 19782697 |
Ref: The integrated stress response-associated signals modulates intestinal tumor cell growth by NSAID-activated gene 1 (NAG-1/MIC-1/PTGF-beta). PMID: 20130018 Ref: Bax deficiency mediated drug resistance can be reversed by endoplasmic reticulum stress induced death signaling. PMID: 20138027 Ref: Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein. PMID: 20145244 Ref: Proteomics-based identification of a tumor-associated antigen and its corresponding autoantibody in gastric cancer. PMID: 20204278 Ref: Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity. PMID: 20232300 Ref: Cell-bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells. PMID: 20536712 Ref: Organometallic osmium arene complexes with potent cancer cell cytotoxicity. PMID: 20977192 |
Ref: The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells. PMID: 20607588 Ref: Glucose regulated protein 78 (GRP78) is overexpressed in colorectal carcinoma and regulates colorectal carcinoma cell growth and apoptosis. PMID: 21156321 Ref: Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer. PMID: 21268086 Ref: GRP78 promoter polymorphism rs391957 as potential predictor for clinical outcome in gastric and colorectal cancer patients. PMID: 21382870 Ref: RNA interference (RNAi) of Ufd1 protein can sensitize a hydroxycamptothecin-resistant colon cancer cell line SW1116/HCPT to hydroxycamptothecin. PMID: 21401896 Ref: Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis. PMID: 21472681 Ref: The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model. PMID: 21555373 Ref: Celecoxib induces cell apoptosis coupled with up-regulation of the expression of VEGF by a mechanism involving ER stress in human colorectal cancer cells. PMID: 21567098 Ref: Sorcin induces a drug-resistant phenotype in human colorectal cancer by modulating Ca(2+) homeostasis. PMID: 22052463 |
Ref: TRAP1 and the proteasome regulatory particle TBP7/Rpt3 interact in the endoplasmic reticulum and control cellular ubiquitination of specific mitochondrial proteins. PMID: 21979464 Ref: Geranylgeranylacetone attenuates cisplatin-induced reductions in cell viability by suppressing the elevation of intracellular p53 content without heat shock protein induction. PMID: 22515118 Ref: GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells. PMID: 22529978 Ref: DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. PMID: 22898250 Ref: Colon cancer cells expressing cell surface GRP78 as a marker for reduced tumorigenicity. PMID: 22945507 Ref: New prognosis biomarkers identified by dynamic proteomic analysis of colorectal cancer. PMID: 22996014 |
Ref: Investigation of the extracts from Bidens pilosa Linn. var. radiata Sch. Bip. for antioxidant activities and cytotoxicity against human tumor cells. PMID: 22382861 Ref: [Preliminary study on glucose regulated protein 78 kD and heat shock protein 20 differential expression between left-sided colon carcinoma and right-sided colon carcinoma]. PMID: 23355246 Ref: 20-O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol induces apoptosis via induction of endoplasmic reticulum stress in human colon cancer cells. PMID: 23381572 Ref: The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer. PMID: 23456958 Ref: Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion. PMID: 23485528 Ref: Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth. PMID: 23759331 Ref: Polymorphisms of glucose-regulated protein 78 and risk of colorectal cancer: a case-control study in southwest China. PMID: 23818965 Ref: Brefeldin a effectively inhibits cancer stem cell-like properties and MMP-9 activity in human colorectal cancer Colo 205 cells. PMID: 23973996 Ref: Effects of parafibromin expression on the phenotypes and relevant mechanisms in the DLD-1 colon carcinoma cell line. PMID: 23991985 Ref: Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1. PMID: 24113185 Ref: Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress. PMID: 24225777 |
Ref: Caffeine inhibits paclitaxelinduced apoptosis in colorectal cancer cells through the upregulation of Mcl1 levels. PMID: 24173825 Ref: Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells. PMID: 24314144 Ref: OSU-CG5, a novel energy restriction mimetic agent, targets human colorectal cancer cells in vitro. PMID: 24464048 Ref: Suppression of colorectal cancer liver metastasis by apolipoprotein(a) kringle V in a nude mouse model through the induction of apoptosis in tumor-associated endothelial cells. PMID: 24699568 Ref: The presence of anti-GRP78 antibodies in the serum of patients with colorectal carcinoma: a potential biomarker for early cancer detection. PMID: 24803280 Ref: Cripto haploinsufficiency affects in vivo colon tumor development. PMID: 24805056 Ref: Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, potentiate the anti-angiogenic effects of bevacizumab by suppressing angiopoietin2, BiP, and Hsp90alpha in human colorectal cancer. PMID: 24945998 Ref: Silencing of JMJD2B induces cell apoptosis via mitochondria-mediated and death receptor-mediated pathway activation in colorectal cancer. PMID: 24957706 Ref: GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the beta-catenin signaling. PMID: 24977433 Ref: GRP78 secreted by colon cancer cells facilitates cell proliferation via PI3K/Akt signaling. PMID: 25227822 Ref: Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades. PMID: 25232957 Ref: Astragalus saponins modulates colon cancer development by regulating calpain-mediated glucose-regulated protein expression. PMID: 25319833 |
Ref: GRP78 mediates the therapeutic efficacy of curcumin on colon cancer. PMID: 25277658 Ref: Glucose-regulated protein 78 (GRP78) regulates colon cancer metastasis through EMT biomarkers and the NRF-2/HO-1 pathway. PMID: 25431258 Ref: Expression of glucose regulated protein 78 (GRP78) determines colorectal cancer response to chemotherapy. PMID: 25519021 Ref: Patulin induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway. PMID: 25577197 Ref: Glucose-regulated protein 78 mediates the therapeutic efficacy of 17-DMAG in colon cancer cells. PMID: 25618598 Ref: GRP78 Protein Expression as Prognostic Values in Neoadjuvant Chemoradiotherapy and Laparoscopic Surgery for Locally Advanced Rectal Cancer. PMID: 25687871 Ref: A therapeutically relevant, 3,3'-diindolylmethane derivative NGD16 attenuates angiogenesis by targeting glucose regulated protein, 78kDa (GRP78). PMID: 25794856 Ref: Overexpressed GRP78 affects EMT and cell-matrix adhesion via autocrine TGF-beta/Smad2/3 signaling. PMID: 25934251 Ref: A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer. PMID: 26064972 Ref: The interplay between GRP78 expression and Akt activation in human colon cancer cells under celecoxib treatment. PMID: 26225471 Ref: Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest. PMID: 26459308 Ref: Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress. PMID: 26496833 |
Ref: GRP78 regulates sensitivity of human colorectal cancer cells to DNA targeting agents. PMID: 25399254 Ref: Crude extract of Rheum palmatum L. Induces cell cycle arrest S phase and apoptosis through mitochondrial-dependent pathways in U-2 OS human osteosarcoma cells. PMID: 25689151 Ref: Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein. PMID: 25823022 Ref: TRAIL-Induced Caspase Activation Is a Prerequisite for Activation of the Endoplasmic Reticulum Stress-Induced Signal Transduction Pathways. PMID: 26212606 Ref: Crocin and quercetin prevent PAT-induced apoptosis in mammalian cells: Involvement of ROS-mediated ER stress pathway. PMID: 26314699 Ref: FAM172A is a tumor suppressor in colorectal carcinoma. PMID: 26637224 Ref: Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis. PMID: 26784903 Ref: Potassium-3-beta-hydroxy-20-oxopregn-5-en-17-alpha-yl sulfate: a novel inhibitor of 78 kDa glucose-regulated protein. PMID: 26893572 Ref: Celecoxib induces apoptosis but up-regulates VEGF via endoplasmic reticulum stress in human colorectal cancer in vitro and in vivo. PMID: 26931344 Ref: Molecular mode of action of NKP-1339 - a clinically investigated ruthenium-based drug - involves ER- and ROS-related effects in colon carcinoma cell lines. PMID: 26988975 Ref: FOXM1 promotes invasion and migration of colorectal cancer cells partially dependent on HSPA5 transactivation. PMID: 27034162 Ref: Endoplasmic reticulum stress induces 5-fluorouracil resistance in human colon cancer cells. PMID: 27163731 Ref: Endoplasmic reticulum stress and IRE-1 signaling cause apoptosis in colon cancer cells in response to andrographolide treatment. PMID: 27166181 Ref: Endoplasmic reticulum stress, unfolded protein response and development of colon adenocarcinoma. PMID: 27220766 Ref: [Roles of glucose-regulated protein 78 in proliferation and migration of human colorectal carcinoma cell line RKO]. PMID: 27256049 Ref: Calnexin, an ER stress-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer. PMID: 27369741 Ref: Elucidation of a novel phenformin derivative on glucose-deprived stress responses in HT-29 cells. PMID: 27392906 Ref: Acetylation modification regulates GRP78 secretion in colon cancer cells. PMID: 27460191 Ref: Non-thermal gas plasma-induced endoplasmic reticulum stress mediates apoptosis in human colon cancer cells. PMID: 27573888 Ref: Bifidobacteria Prevent Tunicamycin-Induced Endoplasmic Reticulum Stress and Subsequent Barrier Disruption in Human Intestinal Epithelial Caco-2 Monolayers. PMID: 27611782 Ref: Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer. PMID: 27622014 Ref: Glucose-regulated protein 78 contributes to the proliferation and tumorigenesis of human colorectal carcinoma via AKT and ERK pathways. PMID: 27634156 |
Ref: Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells. PMID: 27819675 Ref: BRAF-mutated cells activate GCN2-mediated integrated stress response as a cytoprotective mechanism in response to vemurafenib. PMID: 27965097 Ref: Curcumin enhances the effects of irinotecan on colorectal cancer cells through the generation of reactive oxygen species and activation of the endoplasmic reticulum stress pathway. PMID: 28402965 Ref: Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78. PMID: 28551635 Ref: GRP78 Regulates Apoptosis, Cell Survival and Proliferation in 5-Fluorouracil-resistant SNUC5 Colon Cancer Cells. PMID: 28870916 Ref: Citrinin induces apoptosis in human HCT116 colon cancer cells through endoplasmic reticulum stress. PMID: 29165056 Ref: Jolkinolide B induces apoptosis of colorectal carcinoma through ROS-ER stress-Ca(2+)-mitochondria dependent pathway. PMID: 29207638 |
Ref: Knockdown of CEMIP suppresses proliferation and induces apoptosis in colorectal cancer cells: downregulation of GRP78 and attenuation of unfolded protein response. PMID: 29024602 Ref: A Novel Doxorubicin Prodrug with GRP78 Recognition and Nucleus-Targeting Ability for Safe and Effective Cancer Therapy. PMID: 29207873 Ref: The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer. PMID: 29374142 Ref: Resistant starch prevents tumorigenesis of dimethylhydrazine-induced colon tumors via regulation of an ER stress-mediated mitochondrial apoptosis pathway. PMID: 29393371 Ref: A phase I clinical trial of dTCApFs, a derivative of a novel human hormone peptide, for the treatment of advanced/metastatic solid tumors. PMID: 29423221 Ref: The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer. PMID: 29483217 Ref: Ajuba receptor mediates the internalization of tumor-secreted GRP78 into macrophages through different endocytosis pathways. PMID: 29643986 Ref: Suppression of GRP78 sensitizes human colorectal cancer cells to oxaliplatin by downregulation of CD24. PMID: 29805687 Ref: Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer. PMID: 29879413 Ref: Astragaloside attenuates the progression of prostate cancer cells through endoplasmic reticulum stress pathways. PMID: 30128005 Ref: Lysosomal permeabilization and endoplasmic reticulum stress mediate the apoptotic response induced after photoactivation of a lipophilic zinc(II) phthalocyanine. PMID: 30130653 Ref: Aloe-Emodin Induces Endoplasmic Reticulum Stress-Dependent Apoptosis in Colorectal Cancer Cells. PMID: 30199885 Ref: A combination of curcumin and oligomeric proanthocyanidins offer superior anti-tumorigenic properties in colorectal cancer. PMID: 30218018 Ref: Klotho suppresses colorectal cancer through modulation of the unfolded protein response. PMID: 30232408 Ref: 2-Deoxyglucose has distinct and cell line-specific effects on the survival of different cancer cells upon antitumor drug treatment. PMID: 30375744 |