Primary Site >> Colorectal Cancer
Gene >> HSP90AA1
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Ref: Heat shock proteins are differentially expressed in human gastrointestinal cancers. PMID: 8528482 |
Ref: Heat-shock protein expression in cisplatin-sensitive and -resistant human tumor cells. PMID: 8824551 Ref: Increase of P-glycoprotein-mediated drug resistance by hsp 90 beta. PMID: 8991187 |
Ref: KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules. PMID: 10383157 Ref: DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90. PMID: 10564678 Ref: Suppressive subtractive hybridisation reveals differential expression of serglycin, sorcin, bone marrow proteoglycan and prostate-tumour-inducing gene I (PTI-1) in drug-resistant and sensitive tumour cell lines of haematopoetic origin. PMID: 10674022 |
Ref: Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone. PMID: 10962573 Ref: Programmed cell death (PCD). Apoptosis, autophagic PCD, or others? PMID: 11193023 |
Ref: Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis. PMID: 11358818 |
Ref: Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library. PMID: 12177805 Ref: Use of radiolabelled choline as a pharmacodynamic marker for the signal transduction inhibitor geldanamycin. PMID: 12232764 Ref: Heat shock protects HCT116 and H460 cells from TRAIL-induced apoptosis. PMID: 12460647 |
Ref: Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases. PMID: 12633846 Ref: Effect of selenium-enriched broccoli diet on differential gene expression in min mouse liver(1,2). PMID: 12770647 Ref: Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models. PMID: 14600095 |
Ref: Quantitative effects on c-Jun N-terminal protein kinase signaling determine synergistic interaction of cisplatin and 17-allylamino-17-demethoxygeldanamycin in colon cancer cell lines. PMID: 14722256 Ref: Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus. PMID: 15004035 Ref: Heat shock protein 70 is induced in mouse human colon tumor xenografts after sublethal radiofrequency ablation. PMID: 15070600 Ref: SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. PMID: 15235609 Ref: Induction of HSF1 expression is associated with sporadic colorectal cancer. PMID: 15457556 |
Ref: Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells. PMID: 15632176 Ref: Combined inhibition of extracellular signal-regulated kinases and HSP90 sensitizes human colon carcinoma cells to ionizing radiation. PMID: 15735687 Ref: Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models. PMID: 15841378 Ref: 17-Allylamino-17-demethoxygeldanamycin overcomes TRAIL resistance in colon cancer cell lines. PMID: 15993848 |
Ref: Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma. PMID: 16618741 Ref: Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates. PMID: 17034135 Ref: Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. PMID: 17114002 |
Ref: Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells. PMID: 16774932 Ref: Inhibition of G1/S transition potentiates oxaliplatin-induced cell death in colon cancer cell lines. PMID: 17343830 Ref: Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. PMID: 17431102 Ref: Bone morphogenetic protein-4 inhibits heat-induced apoptosis by modulating MAPK pathways in human colon cancer HCT116 cells. PMID: 17640799 Ref: Proteome analysis of metastatic colorectal cancer cells recognized by the lectin Helix pomatia agglutinin (HPA). PMID: 17994629 Ref: R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies. PMID: 18000499 Ref: Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo. PMID: 18025273 Ref: Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex. PMID: 18220746 |
Ref: 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. PMID: 18020435 Ref: Synthesis and evaluation of derrubone and select analogues. PMID: 18154304 Ref: Molecular characterization of hsp90 isoforms in colorectal cancer cells and its association with tumour progression. PMID: 18497978 Ref: Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells. PMID: 18504430 Ref: Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives. PMID: 18676857 |
Ref: 90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1. PMID: 18820127 Ref: Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors. PMID: 18931700 Ref: Indirect participation of Hsp90 in the regulation of the cyclin E turnover. PMID: 18977205 Ref: Tosylcyclonovobiocic acids promote cleavage of the hsp90-associated cochaperone p23. PMID: 19118525 Ref: Evaluation of the Hsp90 inhibitor NVP-AUY922 in multicellular tumour spheroids with respect to effects on growth and PET tracer uptake. PMID: 19324279 Ref: [Association between expressions of HSP70, HSP90 and efficacy of chemotherapy in colorectal cancer patients with unresectable liver metastasis]. PMID: 19598015 |
Ref: Geldanamycin and its anti-cancer activities. PMID: 19850405 Ref: A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. PMID: 20012863 Ref: Stromal hyaluronan interaction with epithelial CD44 variants promotes prostate cancer invasiveness by augmenting expression and function of hepatocyte growth factor and androgen receptor. PMID: 20200161 Ref: Geldanamycin-induced PCNA degradation in isolated Hsp90 complex from cancer cells. PMID: 20394503 Ref: Safety, efficacy, pharmacokinetics, and pharmacodynamics of the combination of sorafenib and tanespimycin. PMID: 20525756 Ref: Increased expression of co-chaperone HOP with HSP90 and HSC70 and complex formation in human colonic carcinoma. PMID: 20617406 Ref: Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation. PMID: 20664927 Ref: Design and synthesis of Hsp90 inhibitors: exploring the SAR of Sansalvamide A derivatives. PMID: 20708938 Ref: A cell-based screen for inhibitors of protein folding and degradation. PMID: 20717760 Ref: Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor. PMID: 20798912 Ref: Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition. PMID: 21129190 |
Ref: Structure based design of heat shock protein 90 inhibitors acting as anticancer agents. PMID: 21306907 Ref: Protein-selective capture to analyze electrophile adduction of hsp90 by 4-hydroxynonenal. PMID: 21749116 Ref: Molecular basis for the actions of Hsp90 inhibitors and cancer therapy. PMID: 21811259 Ref: Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies. PMID: 21932796 |
Ref: Cooperative enhancement of radiosensitivity after combined treatment of 17-(allylamino)-17-demethoxygeldanamycin and celecoxib in human lung and colon cancer cell lines. PMID: 21830942 Ref: Impact of butyrate on PKM2 and HSP90beta expression in human colon tissues of different transformation stages: a comparison of gene and protein data. PMID: 22009386 Ref: Hsp90 inhibitors sensitise human colon cancer cells to topoisomerase I poisons by depletion of key anti-apoptotic and cell cycle checkpoint proteins. PMID: 22138446 Ref: Possible predictors of histopathological response to neoadjuvant chemoradiotherapy for rectal cancer. PMID: 22160161 Ref: Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors. PMID: 22192591 Ref: Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33. PMID: 22451720 Ref: Alterations of the Hsp70/Hsp90 chaperone and the HOP/CHIP co-chaperone system in cancer. PMID: 22669480 Ref: Effect of preoperative fever-range whole-body hyperthermia on immunological markers in patients undergoing colorectal cancer surgery. PMID: 22855633 Ref: Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. PMID: 22984537 |
Ref: A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth. PMID: 23322205 Ref: Hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis: role of heat shock proteins and dissecting effects of hyperthermia. PMID: 23456378 Ref: DTNQ-Pro, a Mimetic Dipeptide, Sensitizes Human Colon Cancer Cells to 5-Fluorouracil Treatment. PMID: 23710334 Ref: Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1alpha and STAT-3. PMID: 23838996 Ref: HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells. PMID: 23840275 Ref: Combining trail with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling. PMID: 23852390 Ref: Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX. PMID: 24185264 Ref: Role of apoptosis in colon cancer biology, therapy, and prevention. PMID: 24273467 |
Ref: p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression. PMID: 24451373 Ref: The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer. PMID: 24682747 Ref: Expression analysis of heat shock protein 90 (HSP90) and Her2 in colon carcinoma. PMID: 24733427 Ref: Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer. PMID: 24962213 Ref: TRAP1-dependent regulation of p70S6K is involved in the attenuation of protein synthesis and cell migration: relevance in human colorectal tumors. PMID: 24962791 Ref: UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib. PMID: 25210794 Ref: TRAP1 is involved in BRAF regulation and downstream attenuation of ERK phosphorylation and cell-cycle progression: a novel target for BRAF-mutated colorectal tumors. PMID: 25239454 Ref: HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy. PMID: 25296971 Ref: Comparative Study of 17-AAG and NVP-AUY922 in Pancreatic and Colorectal Cancer Cells: Are There Common Determinants of Sensitivity? PMID: 25389454 Ref: Ganetespib, a novel Hsp90 inhibitor in patients with KRAS mutated and wild type, refractory metastatic colorectal cancer. PMID: 25444464 |
Ref: Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins. PMID: 24292678 Ref: Upregulation of heat shock proteins and the promotion of damage-associated molecular pattern signals in a colorectal cancer model by modulated electrohyperthermia. PMID: 24973890 Ref: HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells. PMID: 25446253 Ref: Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells. PMID: 25544127 Ref: [Co-inhibition effect of 17-DMAG and oxaliplatin on proliferation and invasion of colorectal cancer cells]. PMID: 25940182 Ref: Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer. PMID: 25982393 Ref: Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: a novel strategy for human BRAF-driven colorectal carcinoma. PMID: 26084290 Ref: Anticancer activity of MPT0G157, a derivative of indolylbenzenesulfonamide, inhibits tumor growth and angiogenesis. PMID: 26087180 Ref: Data supporting the identification of compound for inhibition of survivin of colorectal cancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissues. PMID: 26217796 Ref: Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma. PMID: 26306675 Ref: Adenomatous polyposis coli mutants dominantly activate Hsf1-dependent cell stress pathways through inhibition of microtubule dynamics. PMID: 26320184 Ref: Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancer. PMID: 26416450 Ref: Effect of Root Extracts of Medicinal Herb Glycyrrhiza glabra on HSP90 Gene Expression and Apoptosis in the HT-29 Colon Cancer Cell Line. PMID: 26745117 |
Ref: Hyperthermic intraperitoneal chemotherapy leads to an anticancer immune response via exposure of cell surface heat shock protein 90. PMID: 25867070 Ref: Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore. PMID: 26852363 Ref: Acquired resistance to HSP90 inhibitor 17-AAG and increased metastatic potential are associated with MUC1 expression in colon carcinoma cells. PMID: 26872308 Ref: Heat shock protein 90 is involved in the regulation of HMGA2-driven growth and epithelial-to-mesenchymal transition of colorectal cancer cells. PMID: 26893968 Ref: GRP94/gp96 in Cancer: Biology, Structure, Immunology, and Drug Development. PMID: 26916005 Ref: Paricalcitol Enhances the Chemopreventive Efficacy of 5-Fluorouracil on an Intermediate-Term Model of Azoxymethane-Induced Colorectal Tumors in Rats. PMID: 27020656 Ref: Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94. PMID: 27072698 Ref: HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells. PMID: 27075590 Ref: Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells: The role of drug-irradiation schedule. PMID: 27224913 Ref: A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer. PMID: 27259245 Ref: Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922. PMID: 27391062 Ref: CD24 promoted cancer cell angiogenesis via Hsp90-mediated STAT3/VEGF signaling pathway in colorectal cancer. PMID: 27494878 Ref: Identification of Tumor Antigen AF20 as Glycosylated Transferrin Receptor 1 in Complex with Heat Shock Protein 90 and/or Transporting ATPase. PMID: 27802297 Ref: [Pancreatic acinar neoplasms : Comparative molecular characterization]. PMID: 27807633 Ref: HSP90 inhibitor enhances anti-proliferative and apoptotic effects of celecoxib on HT-29 colorectal cancer cells via increasing BAX/BCL-2 ratio. PMID: 27894402 |
Ref: Re-examining HSPC1 inhibitors. PMID: 28255900 Ref: Extracellular Hsp90 and TGFbeta regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model. PMID: 28302086 Ref: Epigenetic effects of inhibition of heat shock protein 90 (HSP90) in human pancreatic and colon cancer. PMID: 28583846 Ref: FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors. PMID: 28619760 Ref: Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells. PMID: 28789442 Ref: STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1alpha/VEGF signaling pathway. PMID: 29100402 Ref: Hsp90 inhibitor sensitizes TRAIL-mediated apoptosis via chop-dependent DR5 upregulation in colon cancer cells. PMID: 29218092 Ref: Network analysis of common genes related to esophageal, gastric, and colon cancers. PMID: 29379595 Ref: Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis. PMID: 29403306 |
Ref: Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies. PMID: 29242316 Ref: Cdc37 facilitates cell survival of colorectal carcinoma via activating the CDK4 signaling pathway. PMID: 29288563 Ref: Identification of genomic expression differences between right-sided and left-sided colon cancer based on bioinformatics analysis. PMID: 29430186 Ref: Cyclin-dependent kinase 1 targeting improves sensitivity to radiation in BRAF V600E colorectal carcinoma cells. PMID: 29663854 Ref: New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting. PMID: 29807796 Ref: Aberrant expression of stress-induced phosphoprotein 1 in colorectal cancer and its clinicopathologic significance. PMID: 29879402 Ref: Serum heat shock protein 90alpha have an advantage in diagnosis of colorectal cancer at early stage. PMID: 29939072 |