Primary Site >> Colorectal Cancer
Gene >> HMGCR
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Ref: Cholesterol metabolism and colon cancer. PMID: 8502754 |
Ref: Mevalonic acid is limiting for N-linked glycosylation and translocation of the insulin-like growth factor-1 receptor to the cell surface. Evidence for a new link between 3-hydroxy-3-methylglutaryl-coenzyme a reductase and cell growth. PMID: 8663239 Ref: Expression of the low-density lipoprotein receptor, HMG-CoA reductase, and multidrug resistance (Mdr1) genes in colorectal carcinomas. PMID: 8678896 Ref: Effects of monoterpenes and mevinolin on murine colon tumor CT-26 in vitro and its hepatic "metastases" in vivo. PMID: 8886130 |
Ref: Estrogenic regulation of cholesterol biosynthesis and cell growth in DLD-1 human colon cancer cells. PMID: 16293557 |
Ref: Diosgenin, a naturally occurring steroid [corrected] saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells. PMID: 17555873 |
Ref: Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells. PMID: 17869085 Ref: Early induction of LDL receptor gene expression by genistein in DLD-1 colon cancer cell line. PMID: 18621112 Ref: Effect of genistein on cholesterol metabolism-related genes in a colon cancer cell line. PMID: 18850198 |
Ref: Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer. PMID: 20403997 Ref: The relationship between HMGCR genetic variation, alternative splicing, and statin efficacy. PMID: 20587337 |
Ref: HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation. PMID: 24582560 Ref: HMG-CoA reductase expression in primary colorectal cancer correlates with favourable clinicopathological characteristics and an improved clinical outcome. PMID: 24708688 |
Ref: Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. PMID: 25895029 |
Ref: Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer. PMID: 28340513 Ref: Statin use, candidate mevalonate pathway biomarkers, and colon cancer survival in a population-based cohort study. PMID: 28524155 |