Primary Site >> Colorectal Cancer
Gene >> HMGA1
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Ref: High mobility group A1 is expressed in metastatic adenocarcinoma to the liver and intrahepatic cholangiocarcinoma, but not in hepatocellular carcinoma: its potential use in the diagnosis of liver neoplasms. PMID: 14714251 |
Ref: Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas. PMID: 17210682 Ref: Transcriptional control of the human high mobility group A1 gene: basal and oncogenic Ras-regulated expression. PMID: 17510387 |
Ref: A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets. PMID: 20473941 |
Ref: HMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cells. PMID: 22276142 Ref: Caveolin-1 increases aerobic glycolysis in colorectal cancers by stimulating HMGA1-mediated GLUT3 transcription. PMID: 22706202 Ref: High-mobility group A1 protein inhibits p53-mediated intrinsic apoptosis by interacting with Bcl-2 at mitochondria. PMID: 22932725 |
Ref: The Wnt/beta-catenin/T-cell factor 4 pathway up-regulates high-mobility group A1 expression in colon cancer. PMID: 22961697 Ref: MicroRNA-137, an HMGA1 target, suppresses colorectal cancer cell invasion and metastasis in mice by directly targeting FMNL2. PMID: 23201162 Ref: Microarray analysis reveals that high mobility group A1 is involved in colorectal cancer metastasis. PMID: 23835740 |
Ref: HMGA1 interacts with beta-catenin to positively regulate Wnt/beta-catenin signaling in colorectal cancer cells. PMID: 24696416 Ref: HMGA1 silencing restores normal stem cell characteristics in colon cancer stem cells by increasing p53 levels. PMID: 24833610 Ref: High mobility group A1 protein expression reduces the sensitivity of colon and thyroid cancer cells to antineoplastic drugs. PMID: 25409711 |
Ref: HMGA1 drives metabolic reprogramming of intestinal epithelium during hyperproliferation, polyposis, and colorectal carcinogenesis. PMID: 25643065 Ref: Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes. PMID: 26009897 |
Ref: Hmga1 null mouse embryonic fibroblasts display downregulation of spindle assembly checkpoint gene expression associated to nuclear and karyotypic abnormalities. PMID: 26889953 Ref: HMGA1 silencing reduces stemness and temozolomide resistance in glioblastoma stem cells. PMID: 27486901 Ref: MicroRNA-214 suppresses growth, migration and invasion through a novel target, high mobility group AT-hook 1, in human cervical and colorectal cancer cells. PMID: 27537384 Ref: Fecal Metabolome in Hmga1 Transgenic Mice with Polyposis: Evidence for Potential Screen for Early Detection of Precursor Lesions in Colorectal Cancer. PMID: 27696867 |
Ref: H19 promotes the migration and invasion of colon cancer by sponging miR-138 to upregulate the expression of HMGA1. PMID: 28358427 |
Ref: Lessons from the Crypt: HMGA1-Amping up Wnt for Stem Cells and Tumor Progression. PMID: 29618461 Ref: Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles. PMID: 29697014 |