Primary Site >> Colorectal Cancer
Gene >> HIF1A
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Ref: Expression of hypoxia-inducible genes in tumor cells. PMID: 9692838 |
Ref: Quinoxaline 1,4-dioxides: hypoxia-selective therapeutic agents. PMID: 11933073 Ref: Modulation of angiogenesis-related proteins synthesis by sodium butyrate in colon cancer cell line HT29. PMID: 12016145 Ref: Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. PMID: 12149254 Ref: The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis. PMID: 12208766 Ref: A role of histone H4 hypoacetylation in vascular endothelial growth factor expression in colon mucosa adjacent to implanted cancer in athymic mice cecum. PMID: 12865631 |
Ref: Butyrate impairs intestinal tumor cell-induced angiogenesis by inhibiting HIF-1alpha nuclear translocation. PMID: 12559948 Ref: Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. PMID: 12615733 Ref: The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation. PMID: 12657718 Ref: Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma. PMID: 12673675 Ref: Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. PMID: 12727858 Ref: Hyperinsulinemia may boost both hematocrit and iron absorption by up-regulating activity of hypoxia-inducible factor-1alpha. PMID: 14592787 Ref: [Relationship of hypoxia-inducible factor 1 alpha (HIF-1alpha) gene expression with vascular endothelial growth factor (VEGF) and microvessel density (MVD) in human colorectal adenoma and adenocarcinoma]. PMID: 14613646 Ref: Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth. PMID: 14695194 |
Ref: Mutation of the von Hippel-Lindau (VHL) gene in human colorectal carcinoma: association with cytoplasmic accumulation of hypoxia-inducible factor (HIF)-1alpha. PMID: 14965365 Ref: Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. PMID: 14996738 Ref: Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. PMID: 15024076 Ref: Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. PMID: 15026543 Ref: [Expression and pathobiological implication of hypoxia-inducible factor-1alpha in human colorectal carcinoma]. PMID: 15256117 Ref: n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. PMID: 15358633 Ref: Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma. PMID: 15492789 Ref: Expression levels and significance of hypoxia inducible factor-1 alpha and vascular endothelial growth factor in human colorectal adenocarcinoma. PMID: 15498380 Ref: Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. PMID: 15623639 Ref: (125)I-Labeled mouse anti-human carbonic anhydrase IX monoclonal antibody PMID: 22675743 |
Ref: A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia. PMID: 16024616 Ref: A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. PMID: 16061869 Ref: Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors. PMID: 16103077 Ref: Hypoxia-inducible factor-1-mediated activation of stanniocalcin-1 in human cancer cells. PMID: 16109785 Ref: Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells. PMID: 16127434 Ref: Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer. PMID: 16132575 Ref: Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stress. PMID: 16189147 Ref: Modulation of TRAIL-induced tumor cell apoptosis in a hypoxic environment. PMID: 16294025 |
Ref: Hypoxia, angiogenesis and apoptosis markers in locally advanced rectal cancer. PMID: 16052307 Ref: Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis. PMID: 16407833 Ref: Hypoxia-inducible factor-1alpha promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts. PMID: 16452228 Ref: Desferrioxamine, an iron chelator, enhances HIF-1alpha accumulation via cyclooxygenase-2 signaling pathway. PMID: 16527254 Ref: Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. PMID: 16543245 Ref: Hypoxia-inducible factor-1alpha induces the epithelial-mesenchymal transition of human prostatecancer cells. PMID: 16701010 Ref: An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis. PMID: 16777983 Ref: Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. PMID: 16818642 Ref: E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis. PMID: 16819549 Ref: Endogenous markers of hypoxia/anaerobic metabolism and anemia in primary colorectal cancer. PMID: 16827797 Ref: [Modulation of colon cancer cell invasiveness induced by deoxycholic acid]. PMID: 16861876 Ref: Association between ulcerative growth and hypoxia inducible factor-1alpha polymorphisms in colorectal cancer patients. PMID: 16865676 Ref: Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway--a report of the Tumour Angiogenesis Research Group. PMID: 16896001 Ref: Expression of NOS and HIF-1alpha in human colorectal carcinoma and implication in tumor angiogenesis. PMID: 16937436 |
Ref: Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis. PMID: 16819509 Ref: Heparanase promotes angiogenesis through Cox-2 and HIF1alpha. PMID: 16890383 Ref: Exercise associated genes in rat colon mucosa: upregulation of ornithin decarboxylase-1. PMID: 17111318 Ref: Colorectal serrated adenocarcinoma. PMID: 17204027 Ref: Recombinant human erythropoietin alpha modulates the effects of radiotherapy on colorectal cancer microvessels. PMID: 17299396 Ref: Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors. PMID: 17308115 Ref: Clinicopathological significance and linkage of the distribution of HIF-1alpha and GLUT-1 in human primary colorectal cancer. PMID: 17387384 Ref: Isoleucine, an essential amino acid, prevents liver metastases of colon cancer by antiangiogenesis. PMID: 17409434 Ref: 1alpha,25-dihydroxyvitamin D3 (Calcitriol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cells. PMID: 17431122 Ref: Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas. PMID: 17452775 Ref: Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells. PMID: 17488804 Ref: Cumulative expression of HIF-1-alpha, Bax, Bcl-xL and P53 in human colorectal cancer. PMID: 17558861 Ref: Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity. PMID: 17569115 Ref: Expression of the obesity hormone leptin and its receptor correlates with hypoxia-inducible factor-1 alpha in human colorectal cancer. PMID: 17591803 Ref: Hypoxia upregulates carcinoembryonic antigen expression in cancer cells. PMID: 17657737 Ref: Activated VEGFR2/KDR pathway in tumour cells and tumour associated vessels of colorectal cancer. PMID: 17883421 Ref: [Influence of artificial pneumoperitoneal media on colon carcinoma cell proliferation in vitro]. PMID: 18000780 Ref: Up-regulation and stabilization of HIF-1alpha in colorectal carcinomas. PMID: 18023174 Ref: Serum lactate dehydrogenase levels and glycolysis significantly correlate with tumor VEGFA and VEGFR expression in metastatic CRC patients. PMID: 18086000 Ref: [Expression of MMP-2, HIF-1alpha and VEGF in colon adenoma and colon cancer]. PMID: 18172354 Ref: Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex. PMID: 18220746 Ref: Increased VEGF165 expression in HCT116 colon cancer cells after transient transfection with a GFP vector encoding HIF-1 gene. PMID: 18365547 |
Ref: Extracellular matrix and HIF-1 signaling: the role of prolidase. PMID: 17999410 Ref: Differential involvement of vascular endothelial growth factor in the survival of hypoxic colon cancer cells. PMID: 18172321 Ref: Antitumor effect of the angiogenesis inhibitor bevacizumab is dependent on susceptibility of tumors to hypoxia-induced apoptosis. PMID: 18178171 Ref: Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines. PMID: 18292935 Ref: Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum. PMID: 18351386 Ref: Histone deacetylase inhibitors: the anticancer, antimetastatic and antiangiogenic activities of AN-7 are superior to those of the clinically tested AN-9 (Pivanex). PMID: 18506586 Ref: The role of hypoxia in recurrence following resection of Dukes' B colorectal cancer. PMID: 18594846 Ref: Up-regulation of the hypoxia-inducible factor-1 transcriptional pathway in colorectal carcinomas. PMID: 18619649 Ref: Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity. PMID: 18645006 Ref: Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein bid in ex vivo colorectal cancer. PMID: 18648372 Ref: Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) through inhibiting protein synthesis. PMID: 18655183 Ref: Resveratrol inhibits hypoxia-induced metastasis potential enhancement by restricting hypoxia-induced factor-1 alpha expression in colon carcinoma cells. PMID: 18674879 Ref: Role of Hypoxia-inducible factor-1 alpha and Survivin in colorectal carcinoma progression. PMID: 18704463 Ref: Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells. PMID: 18791199 Ref: Hypoxia-inducible factor 1 alpha expression increases during colorectal carcinogenesis and tumor progression. PMID: 18983642 Ref: Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells. PMID: 19020709 Ref: Highlights and prizes of an international meeting. PMID: 19081855 |
Ref: HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. PMID: 19030186 Ref: p53 hot-spot mutants increase tumor vascularization via ROS-mediated activation of the HIF1/VEGF-A pathway. PMID: 19091459 Ref: Relations of TGF-beta1 with HIF-1 alpha, GLUT-1 and longer survival of colorectal cancer patients. PMID: 19142800 Ref: Effect of HIF-1 modulation on the response of two- and three-dimensional cultures of human colon cancer cells to 5-fluorouracil. PMID: 19171477 Ref: Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/hypoxia-inducible factor-1alpha axis. PMID: 19190131 Ref: Immunohistochemical detection of changes in tumor hypoxia. PMID: 19251089 Ref: Cyclooxygenase-2 and Hypoxia-Inducible Factor-1alpha protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis. PMID: 19268443 Ref: The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity. PMID: 19297328 Ref: Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression. PMID: 19298255 Ref: p38alpha blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1alpha- to FoxO-dependent transcription. PMID: 19343039 Ref: Accelerated perinecrotic outgrowth of colorectal liver metastases following radiofrequency ablation is a hypoxia-driven phenomenon. PMID: 19387320 Ref: A novel benzimidazole analogue inhibits the hypoxia-inducible factor (HIF)-1 pathway. PMID: 19433063 Ref: Targeting both HIF-1 and HIF-2 in human colon cancer cells improves tumor response to sunitinib treatment. PMID: 19435875 Ref: Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis. PMID: 19436307 Ref: Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma. PMID: 19529947 Ref: Expression patterns of hypoxic markers at the invasive margin of colorectal cancers and liver metastases. PMID: 19540709 Ref: Inhibition of p38alpha unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism. PMID: 19587525 Ref: GLUT1 gene is a potential hypoxic marker in colorectal cancer patients. PMID: 19619276 Ref: Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1alpha in human colon cancer cells. PMID: 19647009 Ref: Up-regulation of Kruppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha. PMID: 19671674 Ref: Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells. PMID: 19755992 Ref: The mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) enhances the radiation responsiveness of lung and colorectal tumor xenografts. PMID: 19843666 Ref: Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer. PMID: 19843849 Ref: Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications. PMID: 20003271 Ref: [Combination with SN-38 on human colon cancer LoVo cells]. PMID: 20021826 Ref: Mutational analysis of hypoxia-related genes HIF1alpha and CUL2 in common human cancers. PMID: 20078552 |
Ref: Comparison of beta-catenin with TGF-beta1, HIF-1alpha and patients' disease-free survival in human colorectal cancer. PMID: 19898961 Ref: Preoperative radiotherapy downregulates the nuclear expression of hypoxia-inducible factor-1alpha in rectal cancer. PMID: 20001759 Ref: Carbonic anhydrase IX expression in prostate cancer. PMID: 20038959 Ref: Down-regulation of HIF-1alpha by oncolytic reovirus infection independently of VHL and p53. PMID: 20075985 Ref: p38alpha is required for ovarian cancer cell metabolism and survival. PMID: 20169663 Ref: Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells. PMID: 20217131 Ref: (-)-Epigallocatechin gallate inhibits growth and activation of the VEGF/VEGFR axis in human colorectal cancer cells. PMID: 20346928 Ref: HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers. PMID: 20363910 Ref: CD133 expression is a potential prognostic indicator in intrahepatic cholangiocarcinoma. PMID: 20379837 Ref: Clinicopathological significance of nuclear factor-kappa B, HIF-1 alpha, and vascular endothelial growth factor expression in stage III colorectal cancer. PMID: 20398057 Ref: Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. PMID: 20403915 Ref: Targeted knockdown of SEPT9_v1 inhibits tumor growth and angiogenesis of human prostate cancer cells concomitant with disruption of hypoxia-inducible factor-1 pathway. PMID: 20407014 Ref: Identification of differential proteins in colon cancer SW480 cells with HIF1-alpha silence by proteome analysis. PMID: 20429620 Ref: Inhibition of metastasis, angiogenesis, and tumor growth by Chinese herbal cocktail Tien-Hsien Liquid. PMID: 20429953 Ref: Human enhancer of filamentation 1 Is a mediator of hypoxia-inducible factor-1alpha-mediated migration in colorectal carcinoma cells. PMID: 20442290 Ref: Melatonin suppresses tumor angiogenesis by inhibiting HIF-1alpha stabilization under hypoxia. PMID: 20449875 Ref: Hypoxia-inducible factor-1alpha modulates the down-regulation of the homeodomain protein CDX2 in colorectal cancer. PMID: 20514449 Ref: Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells. PMID: 20525878 Ref: Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia. PMID: 20537792 Ref: Single nucleotide polymorphisms in the hypoxia-inducible factor-1 gene and colorectal cancer risk. PMID: 20572162 Ref: Sunitinib deregulates tumor adaptation to hypoxia by inhibiting HIF-1alpha synthesis in HT-29 colon cancer cells. PMID: 20599738 Ref: LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line. PMID: 20599784 Ref: Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. PMID: 20644254 Ref: Association of hypoxia-inducible factor 1-alpha gene polymorphisms and colorectal cancer prognosis. PMID: 20651398 Ref: PIASy stimulates HIF1alpha SUMOylation and negatively regulates HIF1alpha activity in response to hypoxia. PMID: 20661221 Ref: FM19G11: A new modulator of HIF that links mTOR activation with the DNA damage checkpoint pathways. PMID: 20676050 Ref: Inhibition of hypoxia inducible factor-1alpha by dihydroxyphenylethanol, a product from olive oil, blocks microsomal prostaglandin-E synthase-1/vascular endothelial growth factor expression and reduces tumor angiogenesis. PMID: 20682710 Ref: Thymosin beta4 induces the expression of vascular endothelial growth factor (VEGF) in a hypoxia-inducible factor (HIF)-1alpha-dependent manner. PMID: 20691219 Ref: The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine. PMID: 20724530 Ref: Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia. PMID: 20842118 Ref: Clinicopathologic significance of HIF-1alpha, CXCR4, and VEGF expression in colon cancer. PMID: 20953377 Ref: Clinicopathological significance of p53, hypoxia-inducible factor 1alpha, and vascular endothelial growth factor expression in colorectal cancer. PMID: 21036736 Ref: Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1alpha and HIF-2alpha target genes. PMID: 21073737 Ref: Cell death by the quinoxaline dioxide DCQ in human colon cancer cells is enhanced under hypoxia and is independent of p53 and p21. PMID: 21078189 Ref: Effect of hypoxia-inducible factor 1-alpha on Survivin in colorectal cancer. PMID: 21472255 |
Ref: Anti-tumor activity and mechanisms of a novel vascular disrupting agent, (Z)-3,4',5-trimethoxylstilbene-3'-O-phosphate disodium (M410). PMID: 20012336 Ref: No association of the hypoxia-inducible factor-1alpha gene polymorphisms with survival in patients with colorectal cancer. PMID: 20635169 Ref: Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1alpha translational pathway in colorectal cancer cells. PMID: 20857420 Ref: Clinical significance of CD133 and hypoxia inducible factor-1alpha gene expression in rectal cancer after preoperative chemoradiotherapy. PMID: 20970309 Ref: Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1alpha. PMID: 21042279 Ref: Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells. PMID: 21056497 Ref: The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth. PMID: 21239473 Ref: NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1alpha. PMID: 21278237 Ref: Mechanisms of confluence-dependent expression of CD26 in colon cancer cell lines. PMID: 21284881 Ref: Cetuximab enhances the activities of irinotecan on gastric cancer cell lines through downregulating the EGFR pathway upregulated by irinotecan. PMID: 21286718 Ref: Hypoxia and lineage specification of cell line-derived colorectal cancer stem cells. PMID: 21368208 Ref: Associations between single nucleotide polymorphisms of MMP2, VEGF, and HIF1A genes and the risk of developing colorectal cancer. PMID: 21378341 Ref: Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis. PMID: 21390062 Ref: Honokiol inhibits hypoxia-inducible factor-1 pathway. PMID: 21473672 Ref: Antagonistic crosstalk between APC and HIF-1alpha. PMID: 21502812 Ref: [Association of peripheral blood hypoxia-inducible factor-1alpha with metastasis of colorectal cancer]. PMID: 21515475 Ref: [Association of hypoxia-inducible factor 1alpha expression with microlymphatic vessel density and lymph node micrometastasis in rectal cancer]. PMID: 21538273 Ref: Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) by regulating 26 S proteasome-mediated protein degradation in human colon cancer cells. PMID: 21576240 Ref: Effects of inflammatory factors on mesenchymal stem cells and their role in the promotion of tumor angiogenesis in colon cancer. PMID: 21592963 Ref: Pretreatment HIF-1alpha and GLUT-1 expressions do not correlate with outcome after preoperative chemoradiotherapy in rectal cancer. PMID: 21617210 Ref: MicroRNA-22 regulates hypoxia signaling in colon cancer cells. PMID: 21629773 Ref: LDH-A influences hypoxia-inducible factor 1alpha (HIF1 alpha) and is critical for growth of HT29 colon carcinoma cells in vivo. PMID: 21660559 Ref: In vitro antimetastatic effect of Changweiqing through antiinvasion of hypoxic colorectal carcinoma LoVo cells. PMID: 21725877 Ref: The colorectal tumor microenvironment: the next decade. PMID: 21735168 Ref: Role of cyclophilin B in tumorigenesis and cisplatin resistance in hepatocellular carcinoma in humans. PMID: 21748762 Ref: Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer. PMID: 21763680 Ref: Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1alpha (HIF-1alpha), vascular endothelial growth factor (VEGF) and angiogenesis. PMID: 21775820 Ref: Long-term exposure to hypoxia inhibits tumor progression of lung cancer in rats and mice. PMID: 21812995 Ref: The novel Bcl-2 inhibitor ABT-737 is more effective in hypoxia and is able to reverse hypoxia-induced drug resistance in neuroblastoma cells. PMID: 22006676 Ref: Expression of hypoxia-inducible factor 1alpha predicts clinical outcome after preoperative hyperthermo-chemoradiotherapy for locally advanced rectal cancer. PMID: 22104271 Ref: Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma. PMID: 22111880 Ref: Carbonic anhydrase IX, hypoxia-inducible factor-1alpha, ezrin and glucose transporter-1 as predictors of disease outcome in rectal cancer: multivariate Cox survival models following data reduction by principal component analysis of the clinicopathological PMID: 22199327 Ref: Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation. PMID: 22202117 |
Ref: A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice. PMID: 21919080 Ref: Thrombin-dependent modulation of beta1-integrin-mediated signaling up-regulates prolidase and HIF-1alpha through p-FAK in colorectal cancer cells. PMID: 21993963 Ref: In vivo topoisomerase I inhibition attenuates the expression of hypoxia-inducible factor 1alpha target genes and decreases tumor angiogenesis. PMID: 22033674 Ref: Molecular mechanism underlying the detection of colorectal cancer by 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography. PMID: 22065316 Ref: Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells. PMID: 22084398 Ref: Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells. PMID: 22134768 Ref: Angiogenesis in synchronous and metachronous colorectal liver metastases: the liver as a permissive soil. PMID: 22156924 Ref: Transforming growth factor-beta1 induces glutathione peroxidase-1 and protects from H2O2-induced cell death in colon cancer cells via the Smad2/ERK1/2/HIF-1alpha pathway. PMID: 22307228 Ref: Down-regulation of MutS homolog 3 by hypoxia in human colorectal cancer. PMID: 22343000 Ref: SN-38 overcomes chemoresistance of colorectal cancer cells induced by hypoxia, through HIF1alpha. PMID: 22399605 Ref: Overexpression of nuclear NHERF1 in advanced colorectal cancer: association with hypoxic microenvironment and tumor invasive phenotype. PMID: 22440733 Ref: Hypoxia-inducible factor 1 regulated ARC expression mediated hypoxia induced inactivation of the intrinsic death pathway in p53 deficient human colon cancer cells. PMID: 22475487 Ref: Oxidative balance and colon and rectal cancer: interaction of lifestyle factors and genes. PMID: 22531693 Ref: Anti-tumor activity of the novel hexahydrocannabinol analog LYR-8 in Human colorectal tumor xenograft is mediated through the inhibition of Akt and hypoxia-inducible factor-1alpha activation. PMID: 22687485 Ref: Gene expression profiles of tumor regression grade in locally advanced rectal cancer after neoadjuvant chemoradiotherapy. PMID: 22711167 Ref: The HIF-1alpha hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy. PMID: 22719018 Ref: HIF-1alpha-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism. PMID: 22745382 Ref: Low expression of prolyl hydroxylase 2 is associated with tumor grade and poor prognosis in patients with colorectal cancer. PMID: 22802519 Ref: Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition. PMID: 22804960 Ref: Understanding molecular mechanisms in peritoneal dissemination of colorectal cancer : future possibilities for personalised treatment by use of biomarkers. PMID: 22825001 Ref: Main effects and interactions of carbonic anhydrase IX, hypoxia-inducible factor-1alpha, ezrin and glucose transporter-1 in multivariate analysis for disease outcome in rectal cancer. PMID: 22843905 Ref: A systems biology approach to the global analysis of transcription factors in colorectal cancer. PMID: 22852817 Ref: Ethanol enhances tumor angiogenesis in vitro induced by low-dose arsenic in colon cancer cells through hypoxia-inducible factor 1 alpha pathway. PMID: 22872060 Ref: Hypoxia-related proteins in patients with rectal cancer undergoing neoadjuvant combined modality therapy. PMID: 22874607 Ref: Anticancer effects of KI-10F: a novel compound affecting apoptosis, angiogenesis and cell growth in colon cancer. PMID: 22941304 Ref: Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling. PMID: 22943412 Ref: Expression of endothelial cell-specific molecule-1 regulated by hypoxia inducible factor-1alpha in human colon carcinoma: impact of ESM-1 on prognosis and its correlation with clinicopathological features. PMID: 22948784 Ref: Nitric oxide produced endogenously is responsible for hypoxia-induced HIF-1alpha stabilization in colon carcinoma cells. PMID: 22971010 Ref: Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells. PMID: 22992293 Ref: Dietary administration of scallion extract effectively inhibits colorectal tumor growth: cellular and molecular mechanisms in mice. PMID: 23024755 Ref: Single nucleotide polymorphisms in the HIF-1alpha gene and chemoradiotherapy of locally advanced rectal cancer. PMID: 23162650 Ref: Polysaccharide K suppresses angiogenesis in colon cancer cells. PMID: 23181101 |
Ref: Intratumoral expression profiling of genes involved in angiogenesis in colorectal cancer patients treated with chemotherapy plus the VEGFR inhibitor PTK787/ZK 222584 (vatalanib). PMID: 22664478 Ref: Glucose transporter 1 (GLUT1) of anaerobic glycolysis as predictive and prognostic values in neoadjuvant chemoradiotherapy and laparoscopic surgery for locally advanced rectal cancer. PMID: 22847606 Ref: SB365, Pulsatilla saponin D suppresses the proliferation of human colon cancer cells and induces apoptosis by modulating the AKT/mTOR signalling pathway. PMID: 23017388 Ref: Immunohistological expression of HIF-1alpha, GLUT-1, Bcl-2 and Ki-67 in consecutive biopsies during chemoradiotherapy in patients with rectal cancer. PMID: 23030583 Ref: Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2. PMID: 23045284 Ref: The influence of tissue ischemia on biomarker expression in colorectal cancer. PMID: 23060299 Ref: Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment. PMID: 23149916 Ref: c-Myc enhances colon cancer cell-mediated angiogenesis through the regulation of HIF-1alpha. PMID: 23237807 Ref: Piceatannol, a hydroxystilbene natural product, stabilizes HIF-1alpha protein by inhibiting HIF prolyl hydroxylase. PMID: 23261967 Ref: Pharmacologic activation of tumor hypoxia: a means to increase tumor 2-deoxy-2-[18F]fluoro-D-glucose uptake? PMID: 23348791 Ref: p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-kappaB pathway. PMID: 23354733 Ref: Oleuropein, a secoiridoid derived from olive tree, inhibits the proliferation of human colorectal cancer cell through downregulation of HIF-1alpha. PMID: 23368925 Ref: A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-alpha. PMID: 23381944 Ref: Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy. PMID: 23428964 Ref: Mad1 mediates hypoxia-induced doxorubicin resistance in colon cancer cells by inhibiting mitochondrial function. PMID: 23459071 Ref: Activation of AMP-Activated Protein Kinase alpha and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells. PMID: 23589723 Ref: A kinome-wide siRNA screen identifies multiple roles for protein kinases in hypoxic stress adaptation, including roles for IRAK4 and GAK in protection against apoptosis in VHL-/- renal carcinoma cells, despite activation of the NF-kappaB pathway. PMID: 23591012 Ref: Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells. PMID: 23640464 Ref: Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells. PMID: 23651517 Ref: Phosphoglycerate kinase 1 as a promoter of metastasis in colon cancer. PMID: 23727790 Ref: Overexpression of hypoxia inducible factor-1 alpha is an independent risk factor for recurrence after curative resection of colorectal liver metastases. PMID: 23748663 Ref: Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth. PMID: 23759331 Ref: P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1alpha. PMID: 23811286 Ref: Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1alpha and STAT-3. PMID: 23838996 Ref: hypoxia-inducible factors activate CD133 promoter through ETS family transcription factors. PMID: 23840432 Ref: TNFalpha and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells. PMID: 23866118 Ref: Phenethyl isothiocyanate inhibits hypoxia-induced accumulation of HIF-1alpha and VEGF expression in human glioma cells. PMID: 23870899 Ref: Regulation of hypoxia-inducible factor 1alpha (HIF-1alpha) by lysophosphatidic acid is dependent on interplay between p53 and Kruppel-like factor 5. PMID: 23880760 Ref: HIG2 promotes colorectal cancer progression via hypoxia-dependent and independent pathways. PMID: 23916472 Ref: Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma. PMID: 23922772 Ref: Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer (CRC) receiving bevacizumab. PMID: 23930204 Ref: hClock gene expression in human colorectal carcinoma. 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PMID: 27353863 Ref: Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signaling. PMID: 27367023 Ref: miR-526b-3p functions as a tumor suppressor in colon cancer by regulating HIF-1alpha. PMID: 27398161 Ref: HIF-1alpha expression and high microvessel density are characteristic features in serrated colorectal cancer. PMID: 27421843 Ref: A taspine derivative supresses Caco-2 cell growth by competitively targeting EphrinB2 and regulating its pathway. PMID: 27460008 Ref: Ursolic acid sensitized colon cancer cells to chemotherapy under hypoxia by inhibiting MDR1 through HIF-1alpha. PMID: 27604859 Ref: A Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitochondrial Respiration. PMID: 27611801 Ref: Exclusive inhibition of PI3K/Akt/mTOR signaling is not sufficient to prevent PDGF-mediated effects on glycolysis and proliferation in colorectal cancer. PMID: 27626684 Ref: In vitro and in vivo activities of an antitumor peptide HM-3: A special dose-efficacy relationship on an HCT116 xenograft model in nude mice. PMID: 27633584 Ref: Gold nanoparticles enhance anti-tumor effect of radiotherapy to hypoxic tumor. PMID: 27730800 Ref: Filamin A interacting protein 1-like expression inhibits progression in colorectal cancer. PMID: 27750216 Ref: Inhibitory effects of dieckol on hypoxia-induced epithelial-mesenchymal transition of HT29 human colorectal cancer cells. PMID: 27779676 Ref: c-Myc is regulated by HIF-2alpha in chronic hypoxia and influences sensitivity to 5-FU in colon cancer. PMID: 27793037 Ref: Ascorbate availability affects tumor implantation-take rate and increases tumor rejection in Gulo(-/-) mice. PMID: 27800507 Ref: Isorhamnetin Inhibits Reactive Oxygen Species-Dependent Hypoxia Inducible Factor (HIF)-1alpha Accumulation. PMID: 27803454 Ref: Yi Ai Fang, a traditional Chinese herbal formula, impacts the vasculogenic mimicry formation of human colorectal cancer through HIF-1alpha and epithelial mesenchymal transition. PMID: 27806701 Ref: Sestrin2 inhibits hypoxia-inducible factor-1alpha accumulation via AMPK-mediated prolyl hydroxylase regulation. PMID: 27840318 Ref: Hypoxia-induced vasculogenic mimicry formation in human colorectal cancer cells: Involvement of HIF-1a, Claudin-4, and E-cadherin and Vimentin. PMID: 27869227 Ref: Newcastle disease virus degrades HIF-1alpha through proteasomal pathways independent of VHL and p53. PMID: 27902314 Ref: NQO1 inhibits proteasome-mediated degradation of HIF-1alpha. PMID: 27966538 Ref: Hypoxia facilitates epithelial-mesenchymal transition-mediated rectal cancer progress. PMID: 27966740 Ref: Partial Oxygen Pressure Affects the Expression of Prognostic Biomarkers HIF-1 Alpha, Ki67, and CK20 in the Microenvironment of Colorectal Cancer Tissue. 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Ref: Novel synthetic curcumin analogs as potent antiangiogenic agents in colorectal cancer. PMID: 27128654 Ref: Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells. PMID: 27481098 Ref: Exosomes Derived From Hypoxic Colorectal Cancer Cells Promote Angiogenesis Through Wnt4-Induced beta-Catenin Signaling in Endothelial Cells. PMID: 27712599 Ref: Lysyl Oxidase Is a Strong Determinant of Tumor Cell Colonization in Bone. PMID: 27742687 Ref: Increased Expression of Thymosin beta4 Is Independently Correlated with Hypoxia Inducible Factor-1alpha (HIF-1alpha) and Worse Clinical Outcome in Human Colorectal Cancer. PMID: 27744656 Ref: NOX2-ROS-HIF-1alpha signaling is critical for the inhibitory effect of oleanolic acid on rectal cancer cell proliferation. PMID: 27938946 Ref: [Expression of hypoxia-inducible factor 1alpha, glucose transporter 1 and lactate dehydrogenase 5 in colorectal cancer and clinicopathologic significance]. PMID: 28173667 Ref: The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1alpha Levels and Colorectal Cancer Cell Survival under Hypoxia. PMID: 28199842 Ref: Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1alpha stabilization. PMID: 28214471 Ref: Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity. PMID: 28278498 Ref: Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1alpha via the mTOR/p70S6K/4E-BP1 and MAPK pathways. PMID: 28341244 Ref: Increased hypoxia-inducible factor-1alpha in striated muscle of tumor-bearing mice. PMID: 28341633 Ref: Gene expression levels of gamma-glutamyl hydrolase in tumor tissues may be a useful biomarker for the proper use of S-1 and tegafur-uracil/leucovorin in preoperative chemoradiotherapy for patients with rectal cancer. PMID: 28417167 Ref: Inhibition of P-glycoprotein stimulates cell death under Hypoxia-mimicking conditions. PMID: 28421447 Ref: Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis. PMID: 28423551 Ref: Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells. PMID: 28435028 Ref: The YAP1/SIX2 axis is required for DDX3-mediated tumor aggressiveness and cetuximab resistance in KRAS-wild-type colorectal cancer. PMID: 28435452 Ref: MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis. PMID: 28471448 Ref: Inhibition of Ubiquitin-conjugating Enzyme E2 May Activate the Degradation of Hypoxia-inducible Factors and, thus, Overcome Cellular Resistance to Radiation in Colorectal Cancer. PMID: 28476810 Ref: Myocyte enhancer factor 2D promotes colorectal cancer angiogenesis downstream of hypoxia-inducible factor 1alpha. PMID: 28478181 Ref: The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia. PMID: 28486050 Ref: Upregulation of circadian gene 'hClock' contribution to metastasis of colorectal cancer. PMID: 28498393 Ref: Synthesis and biological evaluation of kresoxim-methyl analogues as novel inhibitors of hypoxia-inducible factor (HIF)-1 accumulation in cancer cells. PMID: 28526370 Ref: Clinicopathologic and prognostic significance of immunohistochemical expression of HIF-1alpha, CXCR4 and CA9 in colorectal carcinoma. PMID: 28554753 Ref: Genome-wide network-based pathway analysis of CSF t-tau/Abeta1-42 ratio in the ADNI cohort. PMID: 28558704 Ref: Cell type-dependent HIF1 alpha-mediated effects of hypoxia on proliferation, migration and metastatic potential of human tumor cells. PMID: 28562340 Ref: The novel hypoxia-inducible factor-1alpha inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth. PMID: 28569777 Ref: Oroxylin A suppresses the development and growth of colorectal cancer through reprogram of HIF1alpha-modulated fatty acid metabolism. PMID: 28594405 Ref: Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1alpha and VEGF receptors. PMID: 28594907 Ref: Right- vs. Left-Sided Metastatic Colorectal Cancer: Differences in Tumor Biology and Bevacizumab Efficacy. PMID: 28598398 Ref: Tanshinone IIA inhibits beta-catenin/VEGF-mediated angiogenesis by targeting TGF-beta1 in normoxic and HIF-1alpha in hypoxic microenvironments in human colorectal cancer. PMID: 28602978 Ref: KLF2 inhibits cell growth via regulating HIF-1alpha/Notch-1 signal pathway in human colorectal cancer HCT116 cells. PMID: 28628187 Ref: Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia. PMID: 28756022 Ref: 15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1. PMID: 28757355 Ref: Role of HSPA1L as a cellular prion protein stabilizer in tumor progression via HIF-1alpha/GP78 axis. PMID: 28759037 Ref: Mesua ferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways. 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