Primary Site >> Liver Cancer
Gene >> HGF
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Ref: Interleukin 6, the third mediator of acute-phase reaction, modulates hepatic protein synthesis in human and mouse. Comparison with interleukin 1 beta and tumor necrosis factor-alpha. PMID: 3138137 |
Ref: Growth factors in liver development, regeneration and carcinogenesis. PMID: 1667366 |
Ref: Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells. PMID: 1309612 |
Ref: Effect of intracellular pH and two growth factors, epidermal growth factor and human hepatocyte growth factor, on DNA synthesis in non-regenerating and regenerating hepatocytes and hepatoma cells. PMID: 7862427 Ref: [Development of diagnostic method for liver disease]. PMID: 7996709 Ref: The peroxisome proliferator class of non-genotoxic hepatocarcinogens synergize with epidermal growth factor to promote clonal expansion of initiated rat hepatocytes. PMID: 8001222 |
Ref: Negative selection in hepatic tumor promotion in relation to cancer risk assessment. PMID: 7482557 Ref: Growth control and gene expression in a new hepatocellular carcinoma cell line, Hep40: inhibitory actions of vitamin K. PMID: 7593224 Ref: Hepatocyte growth factor and acute phase proteins in patients with chronic liver diseases. PMID: 8721905 |
Ref: Responsiveness of hepatocytes from dichloroacetic acid or phenobarbital treated mice to growth factors in primary culture. PMID: 8616822 Ref: Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers. PMID: 8930401 Ref: [Gene expression of HGF and its receptor in experimental hepatomas]. PMID: 9275531 |
Ref: Involvement of hepatocyte growth factor in increased integrin expression on HepG2 cells triggered by adhesion to endothelial cells. PMID: 9000597 Ref: Co-expression and regulation of Met and Ron proto-oncogenes in human hepatocellular carcinoma tissues and cell lines. PMID: 9214452 Ref: Analysis of transforming growth factor (TGF)-alpha/epidermal growth factor receptor, hepatocyte growth Factor/c-met,TGF-beta receptor type II, and p53 expression in human hepatocellular carcinomas. PMID: 9815784 |
Ref: Hepatocyte growth factor enhances the invasion activity of human hepatocellular carcinoma cell lines. PMID: 9472107 Ref: Hepatocyte growth factor stimulates DNA synthesis in rat preneoplastic hepatocytes but not in liver carcinoma cells. PMID: 9516398 Ref: Phenobarbital suppresses growth and accelerates restoration of differentiation markers of primary culture rat hepatocytes in the chemically defined hepatocyte growth medium containing hepatocyte growth factor and epidermal growth factor. PMID: 9637786 Ref: [Stimulation of asialoglycoprotein receptor activity after transcatheter arterial embolotherapy in clinical study and continuous infusion of human hepatocyte growth factor in rat]. PMID: 9703826 |
Ref: Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: an immunohistochemical study. PMID: 10220746 |
Ref: u-PA and c-MET mRNA expression is co-ordinately enhanced while hepatocyte growth factor mRNA is down-regulated in human hepatocellular carcinoma. PMID: 10925356 Ref: Hepatocarcinoma cells stimulate hepatocyte growth factor secretion in human liver myofibroblasts. PMID: 10995891 |
Ref: Detection of serum and intrahepatic human hepatocyte growth factor in patients with type C liver diseases. PMID: 11223718 Ref: Characterization of a new rat cell line established from 2'AAF-induced combined hepatocellular cholangiocellular carcinoma. PMID: 11249201 Ref: Comparative genomic hybridization of hepatocellular carcinoma: correlation with fluorescence in situ hybridization in paraffin-embedded tissue. PMID: 11257209 Ref: Trans-resveratrol, a grapevine-derived polyphenol, blocks hepatocyte growth factor-induced invasion of hepatocellular carcinoma cells. PMID: 11408926 Ref: Invasiveness of hepatocellular carcinoma cell lines: contribution of hepatocyte growth factor, c-met, and transcription factor Ets-1. PMID: 11527416 Ref: SF/HGF-c-Met autocrine and paracrine promote metastasis of hepatocellular carcinoma. PMID: 11854908 |
Ref: Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells. PMID: 11981761 Ref: The prognostic molecular markers in hepatocellular carcinoma. PMID: 12046056 Ref: Serum concentrations of human hepatocyte growth factor is a useful indicator for predicting the occurrence of hepatocellular carcinomas in C-viral chronic liver diseases. PMID: 12209727 Ref: Insulin-like growth factor I is a comitogen for hepatocyte growth factor in a rat model of hepatocellular carcinoma. PMID: 12395318 |
Ref: HGF, MET, and matrix-related proteases in hepatocellular carcinoma, fibrolamellar variant, cirrhotic and normal liver. PMID: 12527708 Ref: An absolute role of the PKC-dependent NF-kappaB activation for induction of MMP-9 in hepatocellular carcinoma cells. PMID: 12745093 Ref: Induction of multiple matrix metalloproteinase genes in human hepatocellular carcinoma by hepatocyte growth factor via a transcription factor Ets-1. PMID: 14662117 |
Ref: SU5416 is a potent inhibitor of hepatocyte growth factor receptor (c-Met) and blocks HGF-induced invasiveness of human HepG2 hepatoma cells. PMID: 15288476 Ref: Involvement of cell cycle regulatory proteins and MAP kinase signaling pathway in growth inhibition and cell cycle arrest by a selective cyclooxygenase 2 inhibitor, etodolac, in human hepatocellular carcinoma cell lines. PMID: 15298730 Ref: Negative regulation of hepatocellular carcinoma cell growth by signal regulatory protein alpha1. PMID: 15349900 Ref: Effects of human hepatocyte growth factor on the proliferation of human hepatocytes and hepatocellular carcinoma cell lines. PMID: 15359093 |
Ref: Vascular administration of adenoviral vector soaked in absorbable gelatin sponge particles (GSP) prolongs the transgene expression in hepatocytes. PMID: 15578067 Ref: Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vector-mediated NK4 gene therapy. PMID: 15905856 |
Ref: Non-parenchymal liver cells support the growth advantage in the first stages of hepatocarcinogenesis. PMID: 16081514 Ref: Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways. PMID: 16458870 Ref: The role of a protease inhibitor against hepatectomy. PMID: 16506388 Ref: [Study on the prognostic value of hepatocyte growth factor and c-met for patients with hepatocellular carcinoma]. PMID: 16784653 Ref: Effect of hepatocyte growth factor on endogenous hepatocarcinogenesis in rats fed a choline-deficient L-amino acid-defined diet. PMID: 16786119 Ref: Dysregulation of growth factor signaling in human hepatocellular carcinoma. PMID: 16799620 Ref: Blockage of HGF/c-Met system by gene therapy (adenovirus-mediated NK4 gene) suppresses hepatocellular carcinoma in mice. PMID: 16839638 Ref: Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice. PMID: 17006939 Ref: A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. PMID: 17087938 |
Ref: Potential involvement of the cyclooxygenase-2 pathway in hepatocellular carcinoma-associated angiogenesis. PMID: 17097688 Ref: Evaluation of interleukin-6, interleukin-10 and human hepatocyte growth factor as tumor markers for hepatocellular carcinoma. PMID: 17140760 Ref: [Molecular mechanisms of DHEA and DHEAs on apoptosis and cell cycle arrest via Akt pathway in hepatoma cell lines]. PMID: 17594810 Ref: Angiogenesis soluble factors as hepatocellular carcinoma noninvasive markers for monitoring hepatitis C virus cirrhotic patients awaiting liver transplantation. PMID: 18049111 Ref: Liver stem cells and molecular signaling pathways in hepatocellular carcinoma. PMID: 19360142 |
Ref: Significance of serum hepatocyte growth factor levels in patients with hepatocellular carcinoma undergoing hepatic resection. PMID: 17218078 Ref: Involvement of Egr-1 in HGF-induced elevation of the human 5alpha-R1 gene in human hepatocellular carcinoma cells. PMID: 18215136 Ref: Molecular evaluation of apoptotic versus antiapoptotic angiogenic markers in hepatocellular carcinoma. PMID: 18339319 Ref: New cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis. PMID: 18594539 Ref: KAI1/CD82 suppresses hepatocyte growth factor-induced migration of hepatoma cells via upregulation of Sprouty2. PMID: 18622748 Ref: A novel and effective hepatocyte growth factor kringle 1 domain and p53 cocktail viral gene therapy for the treatment of hepatocellular carcinoma. PMID: 18722051 Ref: S-adenosylmethionine and proliferation: new pathways, new targets. PMID: 18793149 Ref: Deficient response of IL-6 impaired liver regeneration after hepatectomy in patients with viral hepatitis. PMID: 18795707 Ref: Molecular pathogenesis and targeted therapy of hepatocellular carcinoma. PMID: 18854656 |
Ref: Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. PMID: 19220580 Ref: [Comparative genomic classification of human hepatocellular carcinoma]. PMID: 19318328 Ref: Down-regulation of the HGF/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line. PMID: 19447220 |
Ref: Identification and confirmation of biomarkers using an integrated platform for quantitative analysis of glycoproteins and their glycosylations. PMID: 19961239 Ref: Inhibition of poly adenosine diphosphate-ribose polymerase decreases hepatocellular carcinoma growth by modulation of tumor-related gene expression. PMID: 20034026 Ref: The identification of stem cells in human liver diseases and hepatocellular carcinoma. PMID: 20080086 Ref: Hepatocyte growth factor protects hepatoblastoma cells from chemotherapy-induced apoptosis by AKT activation. PMID: 20372801 Ref: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor. PMID: 20977675 Ref: miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines. PMID: 21055388 Ref: Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice. PMID: 21060154 |
Ref: Predictive value of serum biomarkers in patients after portal vein embolization (PVE): a pilot study. PMID: 21273621 Ref: Molecular pathogenesis of hepatocellular carcinoma. PMID: 21303380 Ref: miR-198 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the HGF/c-MET pathway. PMID: 21658389 Ref: Regulation of human hepatocellular carcinoma cells by Spred2 and correlative studies on its mechanism. PMID: 21703232 Ref: Differences in the properties and mirna expression profiles between side populations from hepatic cancer cells and normal liver cells. PMID: 21826246 Ref: Molecular targeted therapy for hepatocellular carcinoma: bench to bedside. PMID: 21829017 Ref: Hepatic regeneration after sublethal partial liver irradiation in cirrhotic rats. PMID: 21952315 Ref: HGF/c-Met related activation of beta-catenin in hepatoblastoma. PMID: 21992464 |
Ref: Serum antithrombin III level is well correlated with multiple indicators for assessment of liver function and diagnostic accuracy for predicting postoperative liver failure in hepatocellular carcinoma patients. PMID: 22353523 Ref: Liver hypertrophy and accelerated growth of implanted tumors in nonembolized liver of rabbit after left portal vein embolization. PMID: 22494913 Ref: Serine protease hepsin regulates hepatocyte size and hemodynamic retention of tumor cells by hepatocyte growth factor signaling in mice. PMID: 22505209 Ref: Growth factor pathways in development and progression of hepatocellular carcinoma. PMID: 22652888 Ref: beta-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice. PMID: 22761897 Ref: Hepatocyte growth factor enhances alternative splicing of the Kruppel-like factor 6 (KLF6) tumor suppressor to promote growth through SRSF1. PMID: 22859706 Ref: Pathways and targets in hepatocellular carcinoma. PMID: 23176622 Ref: Emerging signaling pathways in hepatocellular carcinoma. PMID: 24159576 |
Ref: Targeting the HGF/c-MET pathway in hepatocellular carcinoma. PMID: 23388504 Ref: Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells. PMID: 23537747 Ref: Microarray analyses reveal liver metastasis-related genes in metastatic colorectal cancer cell model. PMID: 23563852 Ref: Celastrol exerts synergistic effects with PHA-665752 and inhibits tumor growth of c-Met-deficient hepatocellular carcinoma in vivo. PMID: 23649759 Ref: Ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling. PMID: 23749170 Ref: Linking MLL and the HGF-MET signaling pathway in liver cancer. PMID: 23934122 Ref: HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma. PMID: 23934123 Ref: Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma. PMID: 23954207 Ref: Cell surface glycan alterations in epithelial mesenchymal transition process of Huh7 hepatocellular carcinoma cell. PMID: 23977005 |
Ref: Radiofrequency ablation suppresses distant tumour growth in a novel rat model of multifocal hepatocellular carcinoma. PMID: 23822114 Ref: Met as a therapeutic target in HCC: facts and hopes. PMID: 24045150 Ref: A phase II trial of a selective c-Met inhibitor tivantinib (ARQ 197) monotherapy as a second- or third-line therapy in the patients with metastatic gastric cancer. PMID: 24337769 Ref: Anti-miR-197 inhibits migration in HCC cells by targeting KAI 1/CD82. PMID: 24613834 Ref: Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment. PMID: 24687604 Ref: Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic steatohepatitis in mice. PMID: 24845607 Ref: Four individually druggable MET hotspots mediate HGF-driven tumor progression. PMID: 24865428 Ref: [Association of expression of HGF and its receptor c-Met to primary colorectal cancers with synchronous liver metastasis]. PMID: 24953371 Ref: Evaluation of Apoptotic Marker Bcl2, CD4+, Human Hepatocyte Growth Factor and Metalloproteinase-9 as Tumor Markers for Patients with Hepatocellular Carcinoma. PMID: 24966485 Ref: Antineoplastic activity of monocrotaline against hepatocellular carcinoma. PMID: 25028149 Ref: MiR-181a-5p is downregulated in hepatocellular carcinoma and suppresses motility, invasion and branching-morphogenesis by directly targeting c-Met. PMID: 25058462 |
Ref: Radioembolization of hepatocellular carcinoma activates liver regeneration, induces inflammation and endothelial stress and activates coagulation. PMID: 24836705 Ref: Leishmanial lipid affords protection against oxidative stress induced hepatic injury by regulating inflammatory mediators and confining apoptosis progress. PMID: 25445725 Ref: Preclinical trials for prevention of tumor progression of hepatocellular carcinoma by LZ-8 targeting c-Met dependent and independent pathways. PMID: 25607934 Ref: Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellular carcinoma cells. PMID: 25620570 Ref: MACC1 suppresses cell apoptosis in hepatocellular carcinoma by targeting the HGF/c-MET/AKT pathway. PMID: 25660117 Ref: Regulation of MET receptor tyrosine kinase signaling by suppressor of cytokine signaling 1 in hepatocellular carcinoma. PMID: 25728680 Ref: Gene expression analysis for evaluation of potential biomarkers in hepatocellular carcinoma. PMID: 25862856 Ref: Knockdown of c-MET induced apoptosis in ABCB1-overexpressed multidrug-resistance cancer cell lines. PMID: 25908454 Ref: Hydrogen peroxide inducible clone-5 mediates reactive oxygen species signaling for hepatocellular carcinoma progression. PMID: 26416447 Ref: Tivantinib induces G2/M arrest and apoptosis by disrupting tubulin polymerization in hepatocellular carcinoma. PMID: 26458953 Ref: Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer. PMID: 26556861 Ref: c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma. PMID: 27508192 |
Ref: SENP1 regulates hepatocyte growth factor-induced migration and epithelial-mesenchymal transition of hepatocellular carcinoma. PMID: 26695141 Ref: Oxidation of heat shock protein 60 and protein disulfide isomerase activates ERK and migration of human hepatocellular carcinoma HepG2. PMID: 26840563 Ref: Trends in the development of MET inhibitors for hepatocellular carcinoma. PMID: 26984595 Ref: Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling. PMID: 27134167 Ref: Sorafenib inhibits macrophage-mediated epithelial-mesenchymal transition in hepatocellular carcinoma. PMID: 27203677 Ref: Biomarker Analyses of Clinical Outcomes in Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib with or without Erlotinib in the SEARCH Trial. PMID: 27220960 Ref: The effect of sequential transcatheter arterial chemoembolization (TACE) and portal venous embolizations (PVE) vs. TACE or PVE alone on rabbit VX2 liver carcinoma and on liver regeneration. PMID: 27466990 Ref: Repression of Human Hepatocellular Carcinoma Growth by Regulating Met/EGFR/VEGFR-Akt/NF-kappaB Pathways with Theanine and Its Derivative, (R)-2-(6,8-Dibromo-2-oxo-2H-chromene-3-carboxamido)-5-(ethylamino)-5-oxopentanoic Ethyl Ester (DTBrC). PMID: 27569455 Ref: Exosomes derived from HCC cells induce sorafenib resistance in hepatocellular carcinoma both in vivo and in vitro. PMID: 27716356 Ref: Peritumoral stromal neutrophils are essential for c-Met-elicited metastasis in human hepatocellular carcinoma. PMID: 27853643 |
Ref: Targeting Signalling Pathways in Hepatocellular Carcinoma. PMID: 27719638 Ref: Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway. PMID: 28075467 Ref: Correlations of microvascular blood flow of contrast-enhanced ultrasound and HGF/c-Met signaling pathway with clinicopathological features and prognosis of patients with hepatocellular carcinoma. PMID: 28243120 Ref: MiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA, VEGFR1, VEGFR2, HGF and MMP2. PMID: 28358369 Ref: Peri-tumor associated fibroblasts promote intrahepatic metastasis of hepatocellular carcinoma by recruiting cancer stem cells. PMID: 28716525 Ref: Therapeutic effects of hepatocyte growth factor-overexpressing dental pulp stem cells on liver cirrhosis in a rat model. PMID: 29150644 Ref: Serum cytokine profiles predict survival benefits in patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective cohort study. PMID: 29258450 |
Ref: Heat stress induced, ligand-independent MET and EGFR signalling in hepatocellular carcinoma. PMID: 28954551 Ref: Deficiency of periostin impairs liver regeneration in mice after partial hepatectomy. PMID: 28965986 Ref: Splenectomy after partial hepatectomy accelerates liver regeneration in mice by promoting tight junction formation via polarity protein Par 3-aPKC. PMID: 29166570 Ref: Transplantation of bone marrow-derived endothelial progenitor cells and hepatocyte stem cells from liver fibrosis rats ameliorates liver fibrosis. PMID: 29375209 Ref: Multi-parameter gene expression profiling of peripheral blood for early detection of hepatocellular carcinoma. PMID: 29391759 Ref: Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway. PMID: 29416603 Ref: The dual blockade of MET and VEGFR2 signaling demonstrates pronounced inhibition on tumor growth and metastasis of hepatocellular carcinoma. PMID: 29712569 Ref: MicroRNA-449a suppresses hepatocellular carcinoma cell growth via G1 phase arrest and the HGF/MET c-Met pathway. PMID: 30108016 Ref: Chemopreventive and antitumor effects of benzyl isothiocynate on HCC models: A possible role of HGF /pAkt/ STAT3 axis and VEGF. PMID: 30216802 Ref: Inhibition of SRC/FAK cue: A novel pathway for the synergistic effect of rosuvastatin on the anti-cancer effect of dasatinib in hepatocellular carcinoma. PMID: 30292831 |