Primary Site >> Stomach Cancer
Gene >> HGF
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Ref: Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase. PMID: 1655790 |
Ref: Stimulation of prostaglandin production by hepatocyte growth factor in human gastric carcinoma cells. PMID: 8243642 Ref: Biologic effect of human hepatocyte growth-factor on human gastric-carcinoma cell-lines. PMID: 21573331 Ref: Reduced tumorigenicity and cell motility of a gastric-carcinoma cell-line by introduction of wild-type p53 gene. PMID: 21573358 Ref: Expression of hepatocyte growth factor(hgf) and C-met gene in human gastric-cancer cell-lines. PMID: 21573474 |
Ref: [Metastasis-related genes]. PMID: 7526801 Ref: [Genetic characteristics of scirrhous gastric carcinomas]. PMID: 7944479 Ref: Effect of hepatocyte growth factor on the expression of E- and P-cadherin in gastric carcinoma cell lines. PMID: 7952499 Ref: Cancer-stromal interaction through growth factor/cytokine networks implicated in growth of stomach cancer. PMID: 8983075 |
Ref: Roles of hepatocyte growth factor and its receptor in gastric mucosa. A cell biological and molecular biological study. PMID: 7729276 |
Ref: Dissociation of c-fos induction and mitogen-activated-protein kinase activation from the hepatocyte-growth-factor-induced motility response in human gastric carcinoma cells. PMID: 8612619 Ref: [Genetic alterations in stomach cancer]. PMID: 8692139 Ref: A splice variant of the c-met proto-oncogene is the predominant population expressed in human gastric mucosa and carcinoma. PMID: 21594385 |
Ref: Effect of hepatocyte growth factor on cell cycle and c-met expression in human gastric cancer cells. PMID: 9413205 Ref: Increased concentration of hepatocyte growth factor in the sera of patients with gastrointestinal cancer. PMID: 21590229 |
Ref: Correlation of hepatocyte growth factor-induced proliferation and calcium-activated potassium current in human gastric cancer cells. PMID: 9459603 Ref: Serum hepatocyte growth factor level associate with gastric cancer progression. PMID: 9854473 Ref: Serum human hepatocyte growth factor (hHGF) is elevated in patients with metastatic gastric carcinoma. PMID: 9951944 |
Ref: Serum human hepatocyte growth factor (hHGF) is elevated in patients with metastatic gastric carcinoma. PMID: 10228863 Ref: Significant correlation between serum level of hepatocyte growth factor and progression of gastric carcinoma. PMID: 10501881 |
Ref: Upregulation of HGF activator inhibitor type 1 but not type 2 along with regeneration of intestinal mucosa. PMID: 10762618 Ref: Elevation of serum hepatocyte growth factor concentration in patients with gastric cancer is mediated by production from tumor tissue. PMID: 10810432 Ref: A novel germ line juxtamembrane Met mutation in human gastric cancer. PMID: 11042681 |
Ref: K252a inhibits the oncogenic properties of Met, the HGF receptor. PMID: 12118367 Ref: Tumor suppression effect using NK4, a molecule acting as an antagonist of HGF, on human gastric carcinomas. PMID: 12136432 |
Ref: Influence of gastrin on the expression of cyclooxygenase-2, hepatocyte growth factor and apoptosis-related proteins in gastric epithelial cells. PMID: 12674216 |
Ref: Suppression of tumor growth, invasion and angiogenesis of human gastric cancer by adenovirus-mediated expression of NK4. PMID: 15026993 Ref: Helicobacter pylori eradication treatment modulates epithelial cell proliferation and tissue content of hepatocyte growth factor in the gastric mucosa. PMID: 15298622 Ref: Adenoviral-mediated gene transduction of the hepatocyte growth factor (HGF) antagonist, NK4, suppresses peritoneal metastases of gastric cancer in nude mice. PMID: 15341989 Ref: Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells. PMID: 15530853 |
Ref: Clinical significance of interleukin-6 (IL-6) in the spread of gastric cancer: role of IL-6 as a prognostic factor. PMID: 15864720 Ref: 15th anniversary of rebamipide: looking ahead to the new mechanisms and new applications. PMID: 16184418 Ref: Modulation of E-cadherin by hepatocyte growth factor induces aggressiveness of gastric carcinoma. PMID: 16244541 |
Ref: Preclinical study of a "tailor-made" combination of NK4-expressing gene therapy and gefitinib (ZD1839, Iressa) for disseminated peritoneal scirrhous gastric cancer. PMID: 16206271 Ref: Effects of COX-2 inhibitor on growth of human gastric cancer cells and its relation to hepatocyte growth factor. PMID: 16243430 Ref: Hepatocyte growth factor/c-met signaling in regulating urokinase plasminogen activator in human stomach cancer: A potential therapeutic target for human stomach cancer. PMID: 16646560 |
Ref: Serum hepatocyte growth factor as a marker of tumor activity in head and neck squamous cell carcinoma. PMID: 17306605 Ref: Association of extracellular cleavage of E-cadherin mediated by MMP-7 with HGF-induced in vitro invasion in human stomach cancer cells. PMID: 17396032 Ref: [Expression of hepatocyte growth factor and its receptor in gastric cancer]. PMID: 18024311 |
Ref: Hepatocyte growth factor promotes cell survival by phosphorylation of BAD in gastric cancer cells. PMID: 18488712 |
Ref: Prognostic value of tumor-related molecular expression in gastric carcinoma. PMID: 19294533 Ref: Molecular characterization and significance for prognosis of free gastric cancer cells in the peritoneal cavity. PMID: 19621724 Ref: Increase in the circulating level of hepatocyte growth factor in pancreatic cancer patients. PMID: 20017454 |
Ref: Expression of Reg IV and Hath1 in neuroendocrine neoplasms. PMID: 19924642 Ref: Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice. PMID: 21060154 |
Ref: Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer. PMID: 22042954 Ref: Comparison between the gastric cancer cell line MKN-45 and the high-potential peritoneal dissemination gastric cancer cell line MKN-45P. PMID: 22531121 Ref: Anti-MET targeted therapy has come of age: the first durable complete response with MetMAb in metastatic gastric cancer. PMID: 22586678 |
Ref: c-Met upregulates aquaporin 3 expression in human gastric carcinoma cells via the ERK signalling pathway. PMID: 22261330 Ref: Essential role of gastric gland mucin in preventing gastric cancer in mice. PMID: 22307328 Ref: Targeted therapy for gastric cancer. PMID: 22552927 Ref: 'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells. PMID: 22738633 |
Ref: Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer. PMID: 23402812 Ref: MYO5B is epigenetically silenced and associated with MET signaling in human gastric cancer. PMID: 23456500 Ref: SB365, Pulsatilla saponin D, targets c-Met and exerts antiangiogenic and antitumor activities. PMID: 23671132 Ref: Hepatocyte growth factor-mediated gastrin-releasing peptide induces IL-8 expression through Ets-1 in gastric cancer cells. PMID: 23924923 Ref: The genomic landscape of oesophagogastric junctional adenocarcinoma. PMID: 24308032 |
Ref: Population pharmacokinetics of rilotumumab, a fully human monoclonal antibody against hepatocyte growth factor, in cancer patients. PMID: 24186235 Ref: Targeting the HGF/MET pathway in gastric cancer. PMID: 24965570 Ref: Gastric cancer--epidemiologic and clinical aspects. PMID: 25167943 Ref: Rilotumumab extends PFS in gastric cancer. PMID: 25185191 Ref: RhoGDI2 is associated with HGF-mediated tumor invasion through VEGF in stomach cancer. PMID: 25253431 Ref: Gastric Cancer: New Drugs - New Strategies. PMID: 26674336 |
Ref: The selective intravenous inhibitor of the MET tyrosine kinase SAR125844 inhibits tumor growth in MET-amplified cancer. PMID: 25504634 Ref: Clinical significance of hepatocyte growth factor/c-Met expression in the assessment of gastric cancer progression. PMID: 25592281 Ref: Targeted therapy in gastric cancer. PMID: 25706252 Ref: c-Met targeting in advanced gastric cancer: An open challenge. PMID: 26049023 Ref: Inhibition of ligand-independent constitutive activation of the Met oncogenic receptor by the engineered chemically-modified antibody DN30. PMID: 26119717 Ref: LincHOTAIR epigenetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer. PMID: 26136075 Ref: Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy. PMID: 26267324 |
Ref: Tumor Specific Recruitment and Reprogramming of Mesenchymal Stem Cells in Tumorigenesis. PMID: 26676563 Ref: Neuropilin-1 is associated with clinicopathology of gastric cancer and contributes to cell proliferation and migration as multifunctional co-receptors. PMID: 26795388 Ref: Current Molecular Targeted Therapy in Advanced Gastric Cancer: A Comprehensive Review of Therapeutic Mechanism, Clinical Trials, and Practical Application. PMID: 26880889 Ref: A novel antagonist anti-cMet antibody with antitumor activities targeting both ligand-dependent and ligand-independent c-Met receptors. PMID: 27144973 Ref: PKG II reverses HGF-triggered cellular activities by phosphorylating serine 985 of c-Met in gastric cancer cells. PMID: 27147579 Ref: Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazo l-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844). PMID: 27355974 |
Ref: Hepatocyte growth factor/MET in cancer progression and biomarker discovery. PMID: 28064454 Ref: Identification of 3-substituted-6-(1-(1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)quinoline derivatives as highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitors via metabolite profiling-based structural optimization. PMID: 28411455 Ref: Predictive value for lymph node metastasis of epithelial-mesenchymal transition and cancer stem cell marker expression in early gastric cancer. PMID: 28595915 Ref: miR-26a/b Inhibit Tumor Growth and Angiogenesis by Targeting the HGF-VEGF Axis in Gastric Carcinoma. PMID: 28738343 Ref: [Checkpoint Inhibitors in the Treatment of Upper Gastrointestinal Tract Tumors]. PMID: 29239193 |
Ref: Exosomes serve as nanoparticles to suppress tumor growth and angiogenesis in gastric cancer by delivering hepatocyte growth factor siRNA. PMID: 29285843 Ref: HGF derived from cancerassociated fibroblasts promotes vascularization in gastric cancer via PI3K/AKT and ERK1/2 signaling. PMID: 29917165 Ref: Current advances of targeting HGF/c-Met pathway in gastric cancer. PMID: 30069449 Ref: Hepatocyte growth factor-induced mesenchymal-epithelial transition factor activation leads to insulin-like growth factor 1 receptor inhibitor unresponsiveness in gastric cancer cells. PMID: 30333869 |