Primary Site >> Colorectal Cancer
Gene >> HGF
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Ref: Cellular and molecular mechanisms of hepatocarcinogenesis. PMID: 1439879 |
Ref: [Metastasis related genes and malignancy in human esophageal, gastric and colorectal cancers]. PMID: 8094950 Ref: Regulation of spreading and growth of colon cancer cells by hepatocyte growth factor. PMID: 8386069 Ref: Molecular mechanism of stomach carcinogenesis. PMID: 8440743 |
Ref: [Metastasis-related genes]. PMID: 7526801 Ref: Hepatocyte growth factor/scatter factor modulates intestinal epithelial cell proliferation and migration. PMID: 8048940 Ref: Hepatocyte growth factor stimulates invasion across reconstituted basement membranes by a new human small intestinal cell line. PMID: 8306528 |
Ref: [Expression of hepatocyte growth factor and its receptor, C-Met in human digestive tissues and different gastric and colonic cancer cell lines]. PMID: 8761141 Ref: Interleukin 4 inhibits hepatocyte growth factor-induced invasion and migration of colon carcinomas. PMID: 8891890 |
Ref: Progression of familial adenomatous polyposis (FAP) colonic cells after transfer of the src or polyoma middle T oncogenes: cooperation between src and HGF/Met in invasion. PMID: 9010033 Ref: Increased concentration of hepatocyte growth factor in the sera of patients with gastrointestinal cancer. PMID: 21590229 |
Ref: Modulation of hepatocyte growth factor-induced scattering of HT29 colon carcinoma cells. Involvement of the MAPK pathway. PMID: 9512500 Ref: Serum hepatocyte growth factor as an index of disease status of patients with colorectal carcinoma. PMID: 9716026 |
Ref: Association of the HGF/SF receptor, c-met, with the cell-surface adhesion molecule, E-cadherin, and catenins in human tumor cells. PMID: 10425198 Ref: CD44 stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrins and c-Met and activation of integrins. PMID: 10485493 |
Ref: Nk4, a new HGF/SF variant, is an antagonist to the influence of HGF/SF on the motility and invasion of colon cancer cells. PMID: 10699931 Ref: Expression of hepatocyte growth factor and c-met in ulcerative colitis. PMID: 10959552 Ref: Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer. PMID: 11073815 Ref: In vivo and in vitro interactions between human colon carcinoma cells and hepatic stellate cells. PMID: 11123428 Ref: Experimental and clinicopathologic studies on the function of the HGF receptor in human colon cancer metastasis. PMID: 11827067 |
Ref: Pericellular activation of hepatocyte growth factor/scatter factor (HGF/SF) in colorectal carcinomas: roles of HGF activator (HGFA) and HGFA inhibitor type 1 (HAI-1). PMID: 11436357 Ref: Bacterial lipopolysaccharide induces transforming growth factor beta and hepatocyte growth factor through toll-like receptor 2 in cultured human colon cancer cells. PMID: 11725828 Ref: Elevated serum hepatocyte growth factor in children and young adults with inflammatory bowel disease. PMID: 11740227 |
Ref: Hepatocyte growth factor levels in liver and blood, and post-operative liver cell proliferation in patients with benign and malignant liver tumors after partial hepatectomy. PMID: 12388921 |
Ref: Met receptor overexpression and oncogenic Ki-ras mutation cooperate to enhance tumorigenicity of colon cancer cells in vivo. PMID: 12651912 Ref: Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin. PMID: 12856716 Ref: Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors. PMID: 12958170 |
Ref: HGF and ligation of alphavbeta5 integrin induce a novel, cancer cell-specific gene expression required for cell scattering. PMID: 14697335 Ref: Inhibition by evodiamine of hepatocyte growth factor-induced invasion and migration of tumor cells. PMID: 15056871 Ref: Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac. PMID: 15059978 Ref: Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell-cell adhesion complexes. PMID: 15077188 Ref: Flavonoids promote cell migration in nontumorigenic colon epithelial cells differing in Apc genotype: implications of matrix metalloproteinase activity. PMID: 15231453 |
Ref: Phase I investigation of recombinant anti-human vascular endothelial growth factor antibody in patients with advanced cancer. PMID: 15737560 Ref: MET signalling in primary colon epithelial cells leads to increased transformation irrespective of aberrant Wnt signalling. PMID: 15785735 Ref: Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor. PMID: 15849510 Ref: Effects of hepatocyte growth factor/scatter factor on the invasion of colorectal cancer cells in vitro. PMID: 15991286 Ref: [Effect of HAI-1 over-expression on in vitro growth and migration/motility of SW620 cells]. PMID: 16044910 |
Ref: Transcriptional targets of hepatocyte growth factor signaling and Ki-ras oncogene activation in colorectal cancer. PMID: 16158056 Ref: Impact of laparotomy and liver resection on the peritoneal concentrations of fibroblast growth factor 2, vascular endothelial growth factor and hepatocyte growth factor. PMID: 16249905 Ref: Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastases. PMID: 16474912 Ref: Genomic instability and tissue expression of angiogenic growth factors in sporadic colorectal cancer. PMID: 16546493 Ref: Hepatocyte growth factor installs a survival platform for colorectal cancer cell invasive growth and overcomes p38 MAPK-mediated apoptosis. PMID: 16677802 Ref: Study of interleukin-6 in the spread of colorectal cancer: the diagnostic significance of IL-6. PMID: 17189976 |
Ref: Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome. PMID: 16945480 Ref: A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth. PMID: 16953230 Ref: Inhibition of colon cancer growth and metastasis by NK4 gene repetitive delivery in mice. PMID: 17467663 Ref: Quantification of MET and hepatocyte growth factor/scatter factor expression in colorectal adenomas, carcinomas and non-neoplastic epithelia by quantitative laser scanning microscopy. PMID: 17549422 Ref: Activation of Src by c-Met overexpression mediates metastatic properties of colorectal carcinoma cells. PMID: 17552361 |
Ref: Up-regulation of the hypoxia-inducible factor-1 transcriptional pathway in colorectal carcinomas. PMID: 18619649 Ref: AAV-HGFK1 and Ad-p53 cocktail therapy prolongs survival of mice with colon cancer. PMID: 18790766 Ref: Deficient response of IL-6 impaired liver regeneration after hepatectomy in patients with viral hepatitis. PMID: 18795707 |
Ref: MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. PMID: 19098908 Ref: Keratinocyte growth factor induces vascular endothelial growth factor-A expression in colorectal cancer cells. PMID: 19148469 Ref: Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. PMID: 19151759 Ref: NK4, an HGF antagonist, prevents hematogenous pulmonary metastasis by inhibiting adhesion of CT26 cells to endothelial cells. PMID: 19234748 Ref: Overexpression of MACC1 leads to downstream activation of HGF/MET and potentiates metastasis and recurrence of colorectal cancer. PMID: 19341507 Ref: Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase. PMID: 19525225 Ref: Serum hepatocyte growth factor as a prognostic marker for stage II or III colorectal cancer patients. PMID: 19569242 Ref: Colon cancer metastasis: MACC1 and Met as metastatic pacemakers. PMID: 19666136 Ref: Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxide. PMID: 19744467 |
Ref: Stromal hyaluronan interaction with epithelial CD44 variants promotes prostate cancer invasiveness by augmenting expression and function of hepatocyte growth factor and androgen receptor. PMID: 20200161 Ref: Hepatocyte growth factor (HGF), heat shock proteins (HSPs) and multidrug resistance protein (MRP) expression in co-culture of colon tumor spheroids with normal cells after incubation with interleukin-1beta (IL-1beta) and/or camptothecin (CPT-11). PMID: 20726333 Ref: Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice. PMID: 21060154 Ref: Independent interactions of phosphorylated beta-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions. PMID: 21152425 Ref: Folate supplementation induces differential dose-dependent modulation of proliferative phenotypes among cancerous and noncancerous oral cell lines in vitro. PMID: 22432562 |
Ref: In vivo antitumor activity of a recombinant IL-7/HGFbeta hybrid cytokine in mice. PMID: 21084268 Ref: Minimally invasive colorectal resection is associated with a transient increase in plasma hepatocyte growth factor levels early after surgery for colon cancer. PMID: 21398340 Ref: Changes in growth factor levels after thermal ablation in a murine model of colorectal liver metastases. PMID: 21418130 Ref: Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: response to met inhibition in patient xenografts and pathologic correlations. PMID: 21447729 Ref: Diosgenin suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition by down-regulation of Mdm2 and vimentin. PMID: 21504235 Ref: Hepatocyte growth factor ameliorates mucosal injuries leading to inhibition of colon cancer development in mice. PMID: 21567095 Ref: Quantitative phospho-proteomic profiling of hepatocyte growth factor (HGF)-MET signaling in colorectal cancer. PMID: 21609022 Ref: Effects of metastasis-associated in colon cancer 1 inhibition by small hairpin RNA on ovarian carcinoma OVCAR-3 cells. PMID: 21923915 Ref: [Expressions of MACC1, HGF, and C-met protein in epithelial ovarian cancer and their significance]. PMID: 21945764 Ref: Enhanced activity of meprin-alpha, a pro-migratory and pro-angiogenic protease, in colorectal cancer. PMID: 22096485 |
Ref: Rack1 promotes epithelial cell-cell adhesion by regulating E-cadherin endocytosis. PMID: 21685945 Ref: A common variant of the MACC1 gene is significantly associated with overall survival in colorectal cancer patients. PMID: 22251819 Ref: Expression of the hepatocyte growth factor and c-Met in colon cancer: correlation with clinicopathological features and overall survival. PMID: 22495710 Ref: MicroRNA-143 targets MACC1 to inhibit cell invasion and migration in colorectal cancer. PMID: 22533346 Ref: Prognostic value of tumor growth factor levels during chemotherapy in patients with metastatic colorectal cancer. PMID: 22580817 Ref: Gene expression profiles of tumor regression grade in locally advanced rectal cancer after neoadjuvant chemoradiotherapy. PMID: 22711167 Ref: The aromatase gene (CYP19A1) variants and circulating hepatocyte growth factor in postmenopausal women. PMID: 22848710 Ref: Circulating MACC1 transcripts in colorectal cancer patient plasma predict metastasis and prognosis. PMID: 23166620 Ref: Human gut flora-fermented nondigestible fraction from cooked bean ( Phaseolus vulgaris L.) modifies protein expression associated with apoptosis, cell cycle arrest, and proliferation in human adenocarcinoma colon cancer cells. PMID: 23194196 |
Ref: Anti-metastatic treatment in colorectal cancer: targeting signaling pathways. PMID: 22973955 Ref: Effect of genomic instability and mutations on the signaling pathways in colon cancer cells. PMID: 23277013 Ref: CD44v6 expression is related to mesenchymal phenotype and poor prognosis in patients with colorectal cancer. PMID: 23404221 Ref: Hepatocyte growth factor activator inhibitor type 1 is a suppressor of intestinal tumorigenesis. PMID: 23447577 Ref: Expression of HGF and Met in human tissues of colorectal cancers: biological and clinical implications for synchronous liver metastasis. PMID: 23532910 Ref: Microarray analyses reveal liver metastasis-related genes in metastatic colorectal cancer cell model. PMID: 23563852 Ref: MACC1 mRNA levels predict cancer recurrence after resection of colorectal cancer liver metastases. PMID: 23665971 Ref: Molecular biomarkers of resistance to anti-EGFR treatment in metastatic colorectal cancer, from classical to innovation. PMID: 23806981 Ref: Effect of c-Met inhibitor SU11274 on human colon cancer cell growth. PMID: 23876900 Ref: Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion. PMID: 23886856 Ref: Role of cMET in the development and progression of colorectal cancer. PMID: 24005867 Ref: Increased TGF-alpha as a mechanism of acquired resistance to the anti-EGFR inhibitor cetuximab through EGFR-MET interaction and activation of MET signaling in colon cancer cells. PMID: 24122793 |
Ref: A PAK6-IQGAP1 complex promotes disassembly of cell-cell adhesions. PMID: 24352566 Ref: Expression of MACC1 and MET in inflammatory bowel disease-associated colonic neoplasia. PMID: 24518605 Ref: A pharmacodynamic/pharmacokinetic study of ficlatuzumab in patients with advanced solid tumors and liver metastases. PMID: 24634378 Ref: Cetuximab-induced MET activation acts as a novel resistance mechanism in colon cancer cells. PMID: 24714091 Ref: Activation of c-Met and upregulation of CD44 expression are associated with the metastatic phenotype in the colorectal cancer liver metastasis model. PMID: 24823486 Ref: Significant survival impact of MACC1 polymorphisms in HER2 positive breast cancer patients. PMID: 24910416 Ref: [Association of expression of HGF and its receptor c-Met to primary colorectal cancers with synchronous liver metastasis]. PMID: 24953371 Ref: Sporadic early-onset colorectal cancer is a specific sub-type of cancer: a morphological, molecular and genetics study. PMID: 25083765 Ref: Possible involvement of tumor-producing VEGF-A in the recruitment of lymphatic endothelial progenitor cells from bone marrow. PMID: 25242215 Ref: MACC1 expression levels as a novel prognostic marker for colorectal cancer. PMID: 25295116 Ref: Role of HGF-MET Signaling in Primary and Acquired Resistance to Targeted Therapies in Cancer. PMID: 28548075 |
Ref: Genomic instability causes HGF gene activation in colon cancer cells, promoting their resistance to necroptosis. PMID: 25244939 Ref: TNF-alpha promotes invasive growth through the MET signaling pathway. PMID: 25306394 Ref: HGF-activated colonic fibroblasts mediates carcinogenesis of colonic epithelial cancer cells via PKC-cMET-ERK1/2-COX-2 signaling. PMID: 25643632 Ref: Differential role of MACC1 expression and its regulation of the HGF/cMet pathway between breast and colorectal cancer. PMID: 25738887 Ref: BATF2 Deficiency Promotes Progression in Human Colorectal Cancer via Activation of HGF/MET Signaling: A Potential Rationale for Combining MET Inhibitors with IFNs. PMID: 25762344 Ref: Metastasis-associated in colon cancer 1 is an independent prognostic biomarker for survival in Klatskin tumor patients. PMID: 25953673 Ref: gamma-Synuclein confers both pro-invasive and doxorubicin-mediated pro-apoptotic properties to the colon adenocarcinoma LS 174T cell line. PMID: 25956278 Ref: Neuropilin-1 as Therapeutic Target for Malignant Melanoma. PMID: 26090340 Ref: Humanized anti-hepatocyte growth factor (HGF) antibody suppresses innate irinotecan (CPT-11) resistance induced by fibroblast-derived HGF. PMID: 26090722 Ref: Overexpression of MACC1 and the association with hepatocyte growth factor/c-Met in epithelial ovarian cancer. PMID: 26137000 Ref: Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon. PMID: 26194191 |
Ref: Expression of hepatocyte growth factor and c-Met is characteristic of alpha-fetoprotein-producing colorectal adenocarcinoma: A report of three cases. PMID: 26870275 Ref: Curcumin mediates reversion of HGF-induced epithelial-mesenchymal transition via inhibition of c-Met expression in DU145 cells. PMID: 26893768 Ref: Predictive Value of Growth Factors and Interleukins for Future Liver Remnant Volume and Colorectal Liver Metastasis Volume Growth Following Portal Vein Embolization and Autologous Stem Cell Application. PMID: 27069178 Ref: Ellagitannin-rich cloudberry inhibits hepatocyte growth factor induced cell migration and phosphatidylinositol 3-kinase/AKT activation in colon carcinoma cells and tumors in Min mice. PMID: 27270323 Ref: PTEN mRNA expression is less pronounced in left- than right-sided colon cancer: a retrospective observational study. PMID: 27296289 Ref: IGF1R and c-met as therapeutic targets for colorectal cancer. PMID: 27470393 Ref: Voltage-gated sodium channel Nav 1.7 promotes gastric cancer progression through MACC1-mediated upregulation of NHE1. PMID: 27529686 Ref: Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer. PMID: 27793046 Ref: Effects and Mechanism of Imatinib in Inhibiting Colon Cancer Cell Proliferation. PMID: 27799652 Ref: Yttrium-90 radioembolization for colorectal cancer liver metastases: a prospective cohort study on circulating angiogenic factors and treatment response. PMID: 28004357 |
Ref: Hepatocyte growth factor/MET in cancer progression and biomarker discovery. PMID: 28064454 Ref: Peripheral blood leucocytes show differential expression of tumour progression-related genes in colorectal cancer patients who have a postoperative intra-abdominal infection: a prospective matched cohort study. PMID: 28214365 Ref: Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors. PMID: 28445144 Ref: Diagnostic Performance of a Novel Multiplex Immunoassay in Colorectal Cancer. PMID: 28476816 Ref: Autophagy-related gene expression in colorectal cancer patients. PMID: 29254294 |
Ref: The Predictive Significance of Metastasis-Associated in Colon Cancer-1 (MACC1) in Primary Breast Cancer. PMID: 29678846 Ref: Targeting the MET oncogene by concomitant inhibition of receptor and ligand via an antibody-"decoy" strategy. PMID: 29693242 |