Primary Site >> Colorectal Cancer
Gene >> HES1
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Ref: Differential inhibitory action of the fungal toxin orellanine on alkaline phosphatase isoenzymes. PMID: 2566329 |
Ref: Notch signaling in gastrointestinal tract (review). PMID: 17143535 Ref: Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. PMID: 17611704 |
Ref: Differential Notch and TGFbeta signaling in primary colorectal tumors and their corresponding metastases. PMID: 18219106 Ref: The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway. PMID: 18320325 Ref: Activation of Notch signaling in human colon adenocarcinoma. PMID: 19020755 |
Ref: gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. PMID: 19147571 |
Ref: The study of effect of tea polyphenols on microsatellite instability colorectal cancer and its molecular mechanism. PMID: 20730438 Ref: [Tea polyphenol inhibits colorectal cancer with microsatellite instability by regulating the expressions of HES1, JAG1, MT2A and MAFA]. PMID: 20836978 |
Ref: Complex interplay between beta-catenin signalling and Notch effectors in intestinal tumorigenesis. PMID: 21205878 Ref: The Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cells. PMID: 21437251 Ref: Approaches to neural stem cells and cancer cells based on natural products. PMID: 21467667 Ref: Gamma-secretase inhibitor, a potential target therapy for MUC2-positive colorectal carcinoma. PMID: 21520992 Ref: Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool. PMID: 21699772 Ref: [Inhibitory effect and mechanism of (-)-epigallocatechin-3-gallate on HT29 and HCT-8 colorectal cancer cell lines and expression of HES1 and JAG1]. PMID: 21866461 Ref: [Expression pattern and clinical significance of hairy enhancer of split 1 in colorectal cancer]. PMID: 22333607 |
Ref: A phase II study of RO4929097 in metastatic colorectal cancer. PMID: 22445247 |
Ref: Identification of small molecule Hes1 modulators as potential anticancer chemotherapeutics. PMID: 23006776 Ref: Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo. PMID: 23418447 Ref: Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling. PMID: 23525843 Ref: Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients. PMID: 23900217 Ref: Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen species. PMID: 23916687 Ref: Knockdown of lymphoid enhancer factor 1 inhibits colon cancer progression in vitro and in vivo. PMID: 24098538 |
Ref: Nonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer. PMID: 23852449 Ref: Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner. PMID: 24265293 Ref: Hes1 is involved in the self-renewal and tumourigenicity of stem-like cancer cells in colon cancer. PMID: 24492635 Ref: Colocalization of beta-catenin with Notch intracellular domain in colon cancer: a possible role of Notch1 signaling in activation of CyclinD1-mediated cell proliferation. PMID: 25073953 Ref: [Effect of siRNA-mediated silencing of Notch2 on proliferation of the HepG2 human hepatocellular carcinoma cells]. PMID: 25180870 |
Ref: Amplified in breast cancer 1 promotes colorectal cancer progression through enhancing notch signaling. PMID: 25263446 Ref: Hypothesis: cell signalling influences age-related risk of colorectal cancer. PMID: 25388238 Ref: HES1 promotes metastasis and predicts poor survival in patients with colorectal cancer. PMID: 25636905 Ref: Hes1 promotes cell proliferation and migration by activating Bmi-1 and PTEN/Akt/GSK3beta pathway in human colon cancer. PMID: 26452029 Ref: Hes1 Increases the Invasion Ability of Colorectal Cancer Cells via the STAT3-MMP14 Pathway. PMID: 26650241 |
Ref: Involvement of Notch-1 in Resistance to Regorafenib in Colon Cancer Cells. PMID: 26419617 Ref: Pien Tze Huang inhibits the proliferation, and induces the apoptosis and differentiation of colorectal cancer stem cells via suppression of the Notch1 pathway. PMID: 26530025 Ref: Deciphering the anti-angiogenic effect of endostatin/cyclophosphamide to normalize tumor micrangium through notch signaling pathway in colon cancer. PMID: 26762567 Ref: An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis. PMID: 26785732 Ref: Reconstitution of TGFBR2 in HCT116 colorectal cancer cells causes increased LFNG expression and enhanced N-acetyl-d-glucosamine incorporation into Notch1. PMID: 27156840 Ref: Loss of Hes1 expression is associated with poor prognosis in colorectal adenocarcinoma. PMID: 27476040 |
Ref: Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma. PMID: 27639802 Ref: Inhibition of the transcriptional repressor complex Bcl-6/BCoR induces endothelial sprouting but does not promote tumor growth. PMID: 27880939 Ref: Delta-like 4/Notch signaling promotes Apc (Min/+) tumor initiation through angiogenic and non-angiogenic related mechanisms. PMID: 28086833 Ref: Metformin depresses overactivated Notch1/Hes1 signaling in colorectal cancer patients with type 2 diabetes mellitus. PMID: 28177944 Ref: STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway. PMID: 28827371 Ref: HES1 Promotes Colorectal Cancer Cell Resistance To 5-Fu by Inducing Of EMT and ABC Transporter Proteins. PMID: 28928869 Ref: The clinicopathological significance of HES1 promoter hypomethylation in patients with colorectal cancer. PMID: 29263679 |
Ref: Notch signaling pathway dampens tumor-infiltrating CD8(+) T cells activity in patients with colorectal carcinoma. PMID: 29096354 Ref: Inhibition of Notch1/Hes1 signaling pathway improves radiosensitivity of colorectal cancer cells. PMID: 29126793 Ref: lncRNA FAM83H-AS1 is associated with the prognosis of colorectal carcinoma and promotes cell proliferation by targeting the Notch signaling pathway. PMID: 29434883 Ref: Kynurenine promotes the goblet cell differentiation of HT-29 colon carcinoma cells by modulating Wnt, Notch and AhR signals. PMID: 29436668 Ref: Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations. PMID: 29453410 Ref: Lycium barbarum Polysaccharide Promotes Maturation of Dendritic Cell via Notch Signaling and Strengthens Dendritic Cell Mediated T Lymphocyte Cytotoxicity on Colon Cancer Cell CT26-WT. PMID: 29619065 Ref: Significance of Notch and Wnt signaling for chemoresistance of colorectal cancer cells HCT116. PMID: 29637602 Ref: Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer. PMID: 29879147 Ref: Modification of alpha2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway. PMID: 29981167 |