Primary Site >> Colorectal Cancer

Gene >> HDAC4

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Ref: Transforming growth factor beta 1 acts as an autocrine-negative growth regulator in colon enterocytic differentiation but not in goblet cell maturation.
PMID: 2288877
 Ref: New p53 related genes in human tumors: significant downregulation in colon and lung carcinomas.
PMID: 16865262
 Ref: HDAC4 promotes growth of colon cancer cells via repression of p21.
PMID: 18632985
 Ref: Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells.
PMID: 19734943
 Ref: SAHA inhibits the growth of colon tumors by decreasing histone deacetylase and the expression of cyclin D1 and survivin.
PMID: 22270866
 Ref: Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment.
PMID: 23149916
Ref: Epigenetic control of HNF-4alpha in colon carcinoma cells affects MUC4 expression and malignancy.
PMID: 23307400
Ref: Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer.
PMID: 23970932
 Ref: Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1.
PMID: 25640947
Ref: Potential anticancer properties and mechanisms of action of curcumin.
PMID: 25667441
Ref: Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation.
PMID: 25752481
Ref: The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death.
PMID: 26510776
 Ref: HDAC-4 regulates claudin-2 expression in EGFR-ERK1/2 dependent manner to regulate colonic epithelial cell differentiation.
PMID: 29152115
 Ref: RARbeta acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells.
PMID: 30252536
Ref: CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathway.
PMID: 30257705