Primary Site >> Colorectal Cancer
Gene >> HDAC3
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Ref: Tumor-associated expression of glycosphingolipid Hanganutziu-Deicher antigen in human cancers. PMID: 6394416 |
Ref: Transforming growth factor beta 1 acts as an autocrine-negative growth regulator in colon enterocytic differentiation but not in goblet cell maturation. PMID: 2288877 |
Ref: The role of nm23 in transforming growth factor beta 1-mediated adherence and growth arrest. PMID: 7819128 Ref: Colon carcinoma cells switch their response to transforming growth factor beta 1 with tumor progression. PMID: 8018559 Ref: Two different signal transduction pathways can be activated by transforming growth factor beta 1 in epithelial cells. PMID: 8175753 |
Ref: Colon carcinoma cells with inactive nm23 show increased motility and response to motility factors. PMID: 7554087 |
Ref: Protein kinase C beta 1 and protein kinase C beta 2 activate p57 mitogen-activated protein kinase and block differentiation in colon carcinoma cells. PMID: 8732668 |
Ref: Identification of novel isoform-selective inhibitors within class I histone deacetylases. PMID: 12975486 |
Ref: Requirement of histone deacetylase activity for signaling by STAT1. PMID: 15123634 |
Ref: Antibody response to a non-conserved C-terminal part of human histone deacetylase 3 in colon cancer patients. PMID: 15981215 Ref: Expression analysis of a subset of coregulators and three nuclear receptors in human colorectal carcinoma. PMID: 16309230 |
Ref: Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer. PMID: 16533812 Ref: CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo. PMID: 16731764 Ref: CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo. PMID: 16891455 |
Ref: Targeting serum antibody for cancer diagnosis: a focus on colorectal cancer. PMID: 17227237 Ref: Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. PMID: 17455259 Ref: The histone deacetylase inhibitors suberoylanilide hydroxamic (Vorinostat) and valproic acid induce irreversible and MDR1-independent resistance in human colon cancer cells. PMID: 17671692 Ref: Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. PMID: 17908689 |
Ref: HDAC3 overexpression and colon cancer cell proliferation and differentiation. PMID: 17849419 Ref: Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. PMID: 18347167 Ref: HDAC4 promotes growth of colon cancer cells via repression of p21. PMID: 18632985 Ref: HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling. PMID: 18769117 |
Ref: Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3. PMID: 18789002 Ref: Decreased levels of autoantibody against histone deacetylase 3 in patients with systemic sclerosis. PMID: 19021012 |
Ref: Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases. PMID: 20068155 |
Ref: HDAC inhibition decreases the expression of EGFR in colorectal cancer cells. PMID: 21464950 Ref: Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. PMID: 21624135 |
Ref: SAHA inhibits the growth of colon tumors by decreasing histone deacetylase and the expression of cyclin D1 and survivin. PMID: 22270866 Ref: Mechanism and stereoselectivity of HDAC I inhibition by (R)-9-hydroxystearic acid in colon cancer. PMID: 22814230 |
Ref: Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment. PMID: 23149916 Ref: Epigenetic control of HNF-4alpha in colon carcinoma cells affects MUC4 expression and malignancy. PMID: 23307400 Ref: Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. PMID: 23395002 Ref: DNA methylation and histone modifications of Wnt genes by genistein during colon cancer development. PMID: 23598468 Ref: HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure. PMID: 23724067 Ref: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. PMID: 23770684 Ref: Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly. PMID: 23874714 Ref: Green tea polyphenol epigallocatechin 3-gallate, contributes to the degradation of DNMT3A and HDAC3 in HCT 116 human colon cancer cells. PMID: 24324066 |
Ref: The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer. PMID: 24919179 Ref: Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition. PMID: 25313085 |
Ref: The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses. PMID: 25307283 Ref: A novel class I histone deacetylase inhibitor, I-7ab, induces apoptosis and arrests cell cycle progression in human colorectal cancer cells. PMID: 25960218 Ref: Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon. PMID: 26388957 Ref: Radiation-induced modulation of immunogenic genes in tumor cells is regulated by both histone deacetylases and DNA methyltransferases. PMID: 26458736 Ref: The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death. PMID: 26510776 |
Ref: Histone modifiers and marks define heterogeneous groups of colorectal carcinomas and affect responses to HDAC inhibitors in vitro. PMID: 27152243 Ref: CBX4 Suppresses Metastasis via Recruitment of HDAC3 to the Runx2 Promoter in Colorectal Carcinoma. PMID: 27864346 Ref: Increased transforming growth factor beta and interleukin 10 transcripts in peripheral blood mononuclear cells of colorectal cancer patients. PMID: 28239283 |
Ref: Colonic transcriptional response to 1alpha,25(OH)2 vitamin D3 in African- and European-Americans. PMID: 28163244 Ref: WD-repeat protein WDR13 is a novel transcriptional regulator of c-Jun and modulates intestinal homeostasis in mice. PMID: 28222755 Ref: Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study. PMID: 28415009 Ref: miR-181d and c-myc-mediated inhibition of CRY2 and FBXL3 reprograms metabolism in colorectal cancer. PMID: 28749470 Ref: Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner. PMID: 29233468 |
Ref: Upregulation of AKAP12 with HDAC3 depletion suppresses the progression and migration of colorectal cancer. PMID: 29484387 Ref: Deregulated expression of HDAC3 in colorectal cancer and its clinical significance. PMID: 29558042 Ref: Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs. PMID: 29924908 Ref: Upregulation of PDL1 expression by resveratrol and piceatannol in breast and colorectal cancer cells occurs via HDAC3/p300mediated NFkappaB signaling. PMID: 30066852 |