Primary Site >> Colorectal Cancer
Gene >> HDAC1
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Ref: p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. PMID: 9618491 |
Ref: Lymphoid enhancer factor-1 blocks adenomatous polyposis coli-mediated nuclear export and degradation of beta-catenin. Regulation by histone deacetylase 1. PMID: 11986304 |
Ref: Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site. PMID: 12626711 Ref: Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter. PMID: 12847090 Ref: Identification of novel isoform-selective inhibitors within class I histone deacetylases. PMID: 12975486 |
Ref: Kruppel-like factor 4 is transactivated by butyrate in colon cancer cells. PMID: 15051827 Ref: Requirement of histone deacetylase activity for signaling by STAT1. PMID: 15123634 Ref: Solid tumors in patients treated for Hodgkin's disease: a report from the German Hodgkin Lymphoma Study Group. PMID: 15205202 |
Ref: Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1. PMID: 15665816 Ref: Histone deacetylase 1: a target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancer. PMID: 15716589 Ref: Clinical significance of enhancer of zeste homolog 2 expression in colorectal cancer cases. PMID: 15837043 Ref: Bax, a predictive marker for therapeutic response to preoperative chemoradiotherapy in patients with rectal carcinoma. PMID: 15891997 Ref: Antibody response to a non-conserved C-terminal part of human histone deacetylase 3 in colon cancer patients. PMID: 15981215 Ref: Expression analysis of a subset of coregulators and three nuclear receptors in human colorectal carcinoma. PMID: 16309230 |
Ref: Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells. PMID: 16467083 Ref: 9-Hydroxystearic acid interferes with EGF signalling in a human colon adenocarcinoma. PMID: 16487928 Ref: The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. PMID: 16510874 Ref: Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer. PMID: 16533812 Ref: N-methylformamide and 9-hydroxystearic acid: two anti-proliferative and differentiating agents with different modes of action in colon cancer cells. PMID: 16702808 Ref: CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo. PMID: 16731764 Ref: CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo. PMID: 16891455 |
Ref: Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. PMID: 17455259 Ref: Differential promoter methylation may be a key molecular mechanism in regulating BubR1 expression in cancer cells. PMID: 17464181 Ref: The histone deacetylase inhibitors suberoylanilide hydroxamic (Vorinostat) and valproic acid induce irreversible and MDR1-independent resistance in human colon cancer cells. PMID: 17671692 Ref: Expression of HDAC1 and CBP/p300 in human colorectal carcinomas. PMID: 17720775 Ref: R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies. PMID: 18000499 Ref: Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation? PMID: 18253084 |
Ref: HDAC3 overexpression and colon cancer cell proliferation and differentiation. PMID: 17849419 Ref: Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. PMID: 18347167 Ref: Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes. PMID: 18382425 Ref: Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. PMID: 18419600 Ref: Histone deacetylase inhibitors: the anticancer, antimetastatic and antiangiogenic activities of AN-7 are superior to those of the clinically tested AN-9 (Pivanex). PMID: 18506586 Ref: The short chain fatty acid butyrate induces promoter demethylation and reactivation of RARbeta2 in colon cancer cells. PMID: 18791934 Ref: Quantitative analysis of histone deacetylase-1 selective histone modifications by differential mass spectrometry. PMID: 19367703 |
Ref: Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3. PMID: 18789002 Ref: Decreased levels of autoantibody against histone deacetylase 3 in patients with systemic sclerosis. PMID: 19021012 Ref: 15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells. PMID: 19198625 Ref: Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress. PMID: 19351825 Ref: ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. PMID: 19437536 Ref: Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells. PMID: 19528666 Ref: JNJ-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity. PMID: 19861438 |
Ref: Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases. PMID: 20068155 Ref: Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. PMID: 20451378 Ref: JNK-mediated transcriptional upregulation of RhoB is critical for apoptosis of HCT-116 colon cancer cells by a novel diarylsulfonylurea derivative. PMID: 20683666 Ref: Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. PMID: 20739454 Ref: Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line. PMID: 20950428 Ref: DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. PMID: 21045206 Ref: Epigenetic silencing of peroxisome proliferator-activated receptor gamma is a biomarker for colorectal cancer progression and adverse patients' outcome. PMID: 21151932 |
Ref: DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells. PMID: 20473858 Ref: Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis. PMID: 21566225 Ref: Expression of histone deacetylase 1 and metastasis-associated protein 1 as prognostic factors in colon cancer. PMID: 21617866 Ref: The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors. PMID: 21742496 |
Ref: SAHA inhibits the growth of colon tumors by decreasing histone deacetylase and the expression of cyclin D1 and survivin. PMID: 22270866 Ref: Epigenetic changes induced by oxidative stress in colorectal cancer cells: methylation of tumor suppressor RUNX3. PMID: 22274925 Ref: Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells. PMID: 22517765 Ref: The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells. PMID: 22647378 Ref: STAT3 repressed USP7 expression is crucial for colon cancer development. PMID: 22750444 Ref: Anti-invasive effects and proapoptotic activity induction by the rexinoid IIF and valproic acid in combination on colon cancer cell lines. PMID: 22753748 Ref: Mechanism and stereoselectivity of HDAC I inhibition by (R)-9-hydroxystearic acid in colon cancer. PMID: 22814230 Ref: UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer. PMID: 23023523 |
Ref: Protocatechualdehyde possesses anti-cancer activity through downregulating cyclin D1 and HDAC2 in human colorectal cancer cells. PMID: 23159608 Ref: Plant polyphenols and oxidative metabolites of the herbal alkenylbenzene methyleugenol suppress histone deacetylase activity in human colon carcinoma cells. PMID: 23476753 Ref: Oxidative stress causes epigenetic alteration of CDX1 expression in colorectal cancer cells. PMID: 23618814 Ref: HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure. PMID: 23724067 Ref: Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis. PMID: 24067901 Ref: Black raspberries protectively regulate methylation of Wnt pathway genes in precancerous colon tissue. PMID: 24129635 |
Ref: The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes. PMID: 23708667 Ref: Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate. PMID: 24518414 Ref: Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells. PMID: 24766560 Ref: The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer. PMID: 24919179 Ref: Overexpression of histone deacetylases in cancer cells is controlled by interplay of transcription factors and epigenetic modulators. PMID: 24948597 Ref: A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKCdelta and E-cadherin. PMID: 25015091 Ref: Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups. PMID: 25203782 Ref: HDAC8 and STAT3 repress BMF gene activity in colon cancer cells. PMID: 25321483 Ref: Predictive gene signatures: molecular markers distinguishing colon adenomatous polyp and carcinoma. PMID: 25423035 |
Ref: Nuclear expression of histone deacetylases and their histone modifications predicts clinical outcome in colorectal cancer. PMID: 25307864 Ref: Trichostatin A, a histone deacetylase inhibitor, reverses epithelial-mesenchymal transition in colorectal cancer SW480 and prostate cancer PC3 cells. PMID: 25434997 Ref: Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer. PMID: 26259750 Ref: Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells. PMID: 26309122 Ref: The positive feedback between Snail and DAB2IP regulates EMT, invasion and metastasis in colorectal cancer. PMID: 26336990 Ref: HDAC1 and HDAC2 independently predict mortality in hepatocellular carcinoma by a competing risk regression model in a Southeast Asian population. PMID: 26352599 Ref: Radiation-induced modulation of immunogenic genes in tumor cells is regulated by both histone deacetylases and DNA methyltransferases. PMID: 26458736 |
Ref: The potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma. PMID: 26423403 Ref: OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors. PMID: 26619963 Ref: Chidamide and 5-flurouracil show a synergistic antitumor effect on human colon cancer xenografts in nude mice. PMID: 26774139 Ref: Pre-clinical characterization of 4SC-202, a novel class I HDAC inhibitor, against colorectal cancer cells. PMID: 26831668 Ref: KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis. PMID: 26839262 Ref: Histone deacetylase 2 regulates doxorubicin (Dox) sensitivity of colorectal cancer cells by targeting ABCB1 transcription. PMID: 26846508 Ref: HDAC1 controls CIP2A transcription in human colorectal cancer cells. PMID: 27029072 Ref: A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division. PMID: 27077950 Ref: Histone modifiers and marks define heterogeneous groups of colorectal carcinomas and affect responses to HDAC inhibitors in vitro. PMID: 27152243 |
Ref: Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models. PMID: 27830268 Ref: Cytoplasmic Localization of RUNX3 via Histone Deacetylase-Mediated SRC Expression in Oxidative-Stressed Colon Cancer Cells. PMID: 27990641 Ref: Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study. PMID: 28415009 Ref: The expression of histone deacetylase HDAC1 correlates with the progression and prognosis of gastrointestinal malignancy. PMID: 28424407 Ref: TCF7L1 recruits CtBP and HDAC1 to repress DICKKOPF4 gene expression in human colorectal cancer cells. PMID: 28450117 Ref: ING2, a tumor associated gene, enhances PAI1 and HSPA1A expression with HDAC1 and mSin3A through the PHD domain and Cterminal. PMID: 28944862 |
Ref: Up-regulation of UVRAG by HDAC1 Inhibition Attenuates 5FU-induced Cell Death in HCT116 Colorectal Cancer Cells. PMID: 29277783 Ref: Sodium butyrate has anti-proliferative, pro-differentiating, and immunomodulatory effects in osteosarcoma cells and counteracts the TNFalpha-induced low-grade inflammation. PMID: 29363375 Ref: Deregulated expression of HDAC3 in colorectal cancer and its clinical significance. PMID: 29558042 Ref: TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma. PMID: 29653964 Ref: Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation. PMID: 29669932 Ref: Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1. PMID: 29803790 Ref: Aneuploidy of chromosome 8 and mutation of circulating tumor cells predict pathologic complete response in the treatment of locally advanced rectal cancer. PMID: 30008877 Ref: RARbeta acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells. PMID: 30252536 |