Primary Site >> Stomach Cancer

Gene >> HBEGF

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Ref: Co-expression of heparin-binding EGF-like growth factor and related peptides in human gastric carcinoma.
PMID: 8621250
 Ref: Significance of the association between heparin-binding epidermal growth factor-like growth factor and CD9 in human gastric cancer.
PMID: 11920609
 Ref: Clinical implications of the EGF receptor/ligand system for tumor progression and survival in gastrointestinal carcinomas: evidence for new therapeutic options.
PMID: 12790326
Ref: Possible chemoresistance-related genes for gastric cancer detected by cDNA microarray.
PMID: 12824904
 Ref: Gastrin regulates the heparin-binding epidermal-like growth factor promoter via a PKC/EGFR-dependent mechanism.
PMID: 14764442
Ref: The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric cancer cells.
PMID: 15300588
 Ref: Canonical WNT signaling pathway and human AREG.
PMID: 16685431
 Ref: Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells.
PMID: 17214962
 Ref: Suppression of proHB-EGF carboxy-terminal fragment nuclear translocation: a new molecular target therapy for gastric cancer.
PMID: 18559618
 Ref: [Expression of heparin-binding epidermal growth factor-like growth factor in patients with gastric carcinoma].
PMID: 19218109
Ref: BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers.
PMID: 19337254
 Ref: Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor.
PMID: 20587521
Ref: HB-EGF inhibition in combination with various anticancer agents enhances its antitumor effects in gastric cancer.
PMID: 20871033
Ref: TGFbeta induces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells.
PMID: 20934403
 Ref: Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells.
PMID: 20946474
Ref: Activation of epidermal growth factor receptor signaling by the prostaglandin E(2) receptor EP4 pathway during gastric tumorigenesis.
PMID: 21205091
Ref: The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer.
PMID: 21482691
 Ref: Treatment of capecitabine-induced hand-foot syndrome using a topical retinoid: A case report.
PMID: 24396465
 Ref: Clinical significance and usefulness of soluble heparin binding-epidermal growth factor in gastric cancer.
PMID: 25717241
Ref: Silencing beta-linked N-acetylglucosamine transferase induces apoptosis in human gastric cancer cells through PUMA and caspase-3 pathways.
PMID: 26397041
 Ref: Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines.
PMID: 27933395
Ref: Expression of the ERBB Family of Ligands and Receptors in Gastric Cancer.
PMID: 28399526
Ref: Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway.
PMID: 29379775
 Ref: Aggressive mutation in a familial adenomatous polyposis syndrome family: when phenotype guides clinical surveillance.
PMID: 29998021