Primary Site >> Colorectal Cancer
Gene >> GUCY2C
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Ref: Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cells. PMID: 18566015 |
Ref: Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer. PMID: 19224751 Ref: GUCY2C reverse transcriptase PCR to stage pN0 colorectal cancer patients. PMID: 19895223 |
Ref: The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling. PMID: 19737566 Ref: Molecular staging estimates occult tumor burden in colorectal cancer. PMID: 21275338 |
Ref: Occult tumor burden predicts disease recurrence in lymph node-negative colorectal cancer. PMID: 21307149 Ref: GUCY2C-targeted cancer immunotherapy: past, present and future. PMID: 22038530 |
Ref: Occult tumor burden contributes to racial disparities in stage-specific colorectal cancer outcomes. PMID: 21887684 Ref: Epitope-targeted cytotoxic T cells mediate lineage-specific antitumor efficacy induced by the cancer mucosa antigen GUCY2C. PMID: 22057677 Ref: Analytic lymph node number establishes staging accuracy by occult tumor burden in colorectal cancer. PMID: 22252429 Ref: GUCY2C molecular staging personalizes colorectal cancer patient management. PMID: 22731908 |
Ref: GUCY2C: at the intersection of obesity and cancer. PMID: 23375388 Ref: Molecular staging of node negative patients with colorectal cancer. PMID: 23459453 Ref: Translating colorectal cancer prevention through the guanylyl cyclase C signaling axis. PMID: 23971873 Ref: Intestinal GUCY2C prevents TGF-beta secretion coordinating desmoplasia and hyperproliferation in colorectal cancer. PMID: 24085786 |
Ref: Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21. PMID: 24217248 Ref: Tumor radiation therapy creates therapeutic vaccine responses to the colorectal cancer antigen GUCY2C. PMID: 24661671 Ref: Selective antigen-specific CD4(+) T-cell, but not CD8(+) T- or B-cell, tolerance corrupts cancer immunotherapy. PMID: 24771148 Ref: GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer. PMID: 25294806 Ref: The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer. PMID: 25304930 |
Ref: Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis. PMID: 26773096 Ref: GUCY2C ligand replacement to prevent colorectal cancer. PMID: 27104761 Ref: Guanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer. PMID: 27251363 Ref: Guanylyl cyclase C signaling axis and colon cancer prevention. PMID: 27688649 Ref: A survey of physician receptivity to molecular diagnostic testing and readiness to act on results for early-stage colon cancer patients. PMID: 27716119 Ref: GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity. PMID: 27853651 Ref: Preclinical Evaluation of a Replication-Deficient Recombinant Adenovirus Serotype 5 Vaccine Expressing Guanylate Cyclase C and the PADRE T-helper Epitope. PMID: 27903079 |
Ref: Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer. PMID: 28162021 Ref: Prime-Boost Immunization Eliminates Metastatic Colorectal Cancer by Producing High-Avidity Effector CD8(+) T Cells. PMID: 28341670 Ref: Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention. PMID: 28396341 Ref: ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice. PMID: 28895923 Ref: The Heat-Stable Enterotoxin Receptor, Guanylyl Cyclase C, as a Pharmacological Target in Colorectal Cancer Immunotherapy: A Bench-to-Bedside Current Report. PMID: 28914772 |
Ref: Modeling qRT-PCR dynamics with application to cancer biomarker quantification. PMID: 28504051 Ref: Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases. PMID: 29615399 Ref: The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. PMID: 30131940 Ref: Targeting the paracrine hormone-dependent guanylate cyclase/cGMP/phosphodiesterases signaling pathway for colorectal cancer prevention. PMID: 30189250 Ref: Non-thermal plasma induces immunogenic cell death in vivo in murine CT26 colorectal tumors. PMID: 30228954 |