Primary Site >> Colorectal Cancer
Gene >> GRP
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Ref: [Gut hormones with activity to modulate cellular growth]. PMID: 2083220 Ref: Specific binding and growth effects of bombesin-related peptides on mouse colon cancer cells in vitro. PMID: 2208141 |
Ref: Characterization of functional receptors for gastrointestinal hormones on human colon cancer cells. PMID: 1310640 Ref: A potent bombesin receptor antagonist inhibits bombesin-stimulated growth of mouse colon cancer cells in vitro: absence of autocrine effects. PMID: 1323998 |
Ref: Inhibitory effects of antagonists of bombesin/gastrin releasing peptide (GRP) and somatostatin analog (RC-160) on growth of HT-29 human colon cancers in nude mice. PMID: 7946450 |
Ref: High-affinity binding sites for gastrin-releasing peptide on human colorectal cancer tissue but not uninvolved mucosa. PMID: 7734305 Ref: Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II. PMID: 8704275 Ref: In-vivo effect of somatostatin analog, lanreotide, and/or grp antagonist, bim-26226, on the growth of colon-cancer peritoneal carcinomatosis in the rat. PMID: 21552947 |
Ref: Glucose-regulated stresses induce resistance to camptothecin in human cancer cells. PMID: 8903483 |
Ref: Constitutive activation of the gastrin-releasing peptide receptor expressed by the nonmalignant human colon epithelial cell line NCM460. PMID: 9366567 |
Ref: Bombesin stimulates adhesion, spreading, lamellipodia formation, and proliferation in the human colon carcinoma Isreco1 cell line. PMID: 10029091 Ref: Aberrant expression of gastrin-releasing peptide and its receptor by well-differentiated colon cancers in humans. PMID: 10070042 Ref: High gastrin releasing peptide receptor mRNA level is related to tumour dedifferentiation and lymphatic vessel invasion in human colon cancer. PMID: 10211100 |
Ref: Bombesin family receptor and ligand gene expression in human colorectal cancer and normal mucosa. PMID: 10638978 Ref: Gastrin-releasing peptide is a mitogen and a morphogen in murine colon cancer. PMID: 10939592 Ref: Characterization of gastrin-releasing peptide and its receptor aberrantly expressed by human colon cancer cell lines. PMID: 10953054 |
Ref: Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells. PMID: 11292836 |
Ref: Contribution of gastrin-releasing peptide and its receptor to villus development in the murine and human gastrointestinal tract. PMID: 11960700 Ref: Bombesin stimulates invasion and migration of Isreco1 colon carcinoma cells in a Rho-dependent manner. PMID: 12183443 |
Ref: Quantitative immunohistochemistry by measuring cumulative signal strength accurately measures receptor number. PMID: 12533529 Ref: Expression of GRP and its receptor in well-differentiated colon cancer cells correlates with the presence of focal adhesion kinase phosphorylated at tyrosines 397 and 407. PMID: 12871985 |
Ref: Transcriptional activation of the human gastrin-releasing peptide receptor gene in gastrointestinal and prostatic epithelial cancer cells. PMID: 14742912 Ref: Phosphorylation of focal adhesion kinase tyrosine 397 critically mediates gastrin-releasing peptide's morphogenic properties. PMID: 14978737 Ref: Stimulation of proliferation and migration of a colorectal cancer cell line by amidated and glycine-extended gastrin-releasing peptide via the same receptor. PMID: 15498503 Ref: (99m)Tc-(Hydrazinonicotinic acid-beta-Ala-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2)(tricine)(TPPTS) PMID: 20641678 |
Ref: Transient upregulation of GRP and its receptor critically regulate colon cancer cell motility during remodeling. PMID: 15890713 |
Ref: Synthesis, expression and biological activity of the prohormone for gastrin releasing peptide (ProGRP). PMID: 16223866 Ref: Consequence of gastrin-releasing peptide receptor activation in a human colon cancer cell line: a proteomic approach. PMID: 16739997 |
Ref: Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells. PMID: 16909108 Ref: Gastrin-releasing peptide mediates its morphogenic properties in human colon cancer by upregulating intracellular adhesion protein-1 (ICAM-1) via focal adhesion kinase. PMID: 16920698 Ref: C-terminal fragments of the gastrin-releasing peptide precursor stimulate cell proliferation via a novel receptor. PMID: 17122080 Ref: Recombinant C-terminal fragments of the gastrin-releasing peptide precursor are bioactive. PMID: 17395367 |
Ref: GRP-induced up-regulation of Hsp72 promotes CD16+/94+ natural killer cell binding to colon cancer cells causing tumor cell cytolysis. PMID: 18350254 |
Ref: Expression of GRP and its receptor is associated with improved survival in patients with colon cancer. PMID: 19430935 |
Ref: In vivo MR/optical imaging for gastrin releasing peptide receptor of prostate cancer tumor using Gd-TTDA-NP-BN-Cy5.5. PMID: 20493715 Ref: Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer. PMID: 21268086 Ref: Gastrin-releasing peptide signaling alters colon cancer invasiveness via heterochromatin protein 1Hsbeta. PMID: 21281799 Ref: Preclinical evaluation of a new bombesin analog for imaging of gastrin-releasing peptide receptors. PMID: 21711115 Ref: Identification of ChIP-seq mapped targets of HP1beta due to bombesin/GRP receptor activation. PMID: 22704345 |
Ref: Pro-GRP-derived peptides are expressed in colorectal cancer cells and tumors and are biologically active in vivo. PMID: 22202166 Ref: Combination of gastrin-releasing peptide antagonist with cytotoxic agents produces synergistic inhibition of growth of human experimental colon cancers. PMID: 22751419 |
Ref: Galpha13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration. PMID: 24958816 |
Ref: Investigation of bombesin peptide as a targeting ligand for the gastrin releasing peptide (GRP) receptor. PMID: 27670095 |
Ref: Independent prognostic genes and mechanism investigation for colon cancer. PMID: 29653552 Ref: Clinical Application of Pro-Gastrin-Releasing Peptide. PMID: 30146822 |