Primary Site >> Colorectal Cancer

Gene >> GRB2

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Ref: Interactions between the epidermal growth factor receptor and type I protein kinase A: biological significance and therapeutic implications.
PMID: 9563874
 Ref: Defective cleavage of membrane bound TGFalpha leads to enhanced activation of the EGF receptor in malignant cells.
PMID: 10773880
 Ref: Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells.
PMID: 12748850
 Ref: Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects.
PMID: 15059917
 Ref: Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling.
PMID: 16241905
 Ref: Gab1 but not Grb2 mediates tumor progression in Met overexpressing colorectal cancer cells.
PMID: 18192688
Ref: Tyrosine phosphorylation of netrin receptors in netrin-1 signaling.
PMID: 18253061
Ref: New insight into the key proteins and pathways involved in the metastasis of colorectal carcinoma.
PMID: 18425376
 Ref: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway.
PMID: 20136087
Ref: Extracellular domain dependence of PTPalpha transforming activity.
PMID: 20545765
Ref: Phenethyl isothiocyanate inhibited tumor migration and invasion via suppressing multiple signal transduction pathways in human colon cancer HT29 cells.
PMID: 20863062
 Ref: Endocytosis of resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells.
PMID: 21467134
Ref: Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells.
PMID: 21622897
 Ref: Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes.
PMID: 22285593
 Ref: Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis.
PMID: 23280667
 Ref: Gene expression profiling-derived immunohistochemistry signature with high prognostic value in colorectal carcinoma.
PMID: 24173294
Ref: Met receptor-induced Grb2 or Shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions.
PMID: 24708867
Ref: SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1.
PMID: 24775912
Ref: Clinical significance of GAB2, a scaffolding/docking protein acting downstream of EGFR in human colorectal cancer.
PMID: 25029990
 Ref: Crude extract of Rheum palmatum L inhibits migration and invasion of LS1034 human colon cancer cells acts through the inhibition of matrix metalloproteinase-2/-9 by MAPK signaling.
PMID: 24497447
Ref: Gab2 is a novel prognostic factor for colorectal cancer patients.
PMID: 26045784
 Ref: Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer.
PMID: 26754532
Ref: NADPH Oxidase 1 Activity and ROS Generation Are Regulated by Grb2/Cbl-Mediated Proteasomal Degradation of NoxO1 in Colon Cancer Cells.
PMID: 26781991
Ref: SH3GL1 inhibition reverses multidrug resistance in colorectal cancer cells by downregulation of MDR1/P-glycoprotein via EGFR/ERK/AP-1 pathway.
PMID: 27220321
 Ref: Elevated Gab2 induces tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levels.
PMID: 28420432
 Ref: BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines.
PMID: 29326440
Ref: Inflammatory genes are novel prognostic biomarkers for colorectal cancer.
PMID: 29693170
Ref: MicroRNA-485 plays tumour-suppressive roles in colorectal cancer by directly targeting GAB2.
PMID: 29781037
Ref: LncRNA snaR upregulates GRB2-associated binding protein 2 and promotes proliferation of ovarian carcinoma cells.
PMID: 30093110