Primary Site >> Colorectal Cancer
Gene >> GLI1
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Ref: Increase of GKLF messenger RNA and protein expression during progression of breast cancer. PMID: 11103818 |
Ref: Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment. PMID: 15170664 |
Ref: Identification and characterization of rat Desert hedgehog and Indian hedgehog genes in silico. PMID: 15645142 Ref: Comparative genomics on Sonic hedgehog orthologs. PMID: 16142377 |
Ref: Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation. PMID: 16299030 Ref: Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer. PMID: 16701100 |
Ref: Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas. PMID: 17461467 Ref: Hedgehog signaling pathway is inactive in colorectal cancer cell lines. PMID: 17683069 |
Ref: Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation. PMID: 19280222 Ref: Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA. PMID: 19887615 Ref: Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion. PMID: 20049737 |
Ref: Distinct expression patterns of hedgehog ligands between cultured and primary colorectal cancers are associated with aberrant methylation of their promoters. PMID: 19856079 Ref: Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling. PMID: 19861162 Ref: cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells. PMID: 20957031 |
Ref: Hedgehog signaling drives cellular survival in human colon carcinoma cells. PMID: 21135115 Ref: Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation. PMID: 21610148 Ref: Differential expression profiles of the Hedgehog signaling pathway between microsatellite-stable and microsatellite-unstable colorectal cancers. PMID: 21725600 Ref: Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. PMID: 21747117 Ref: The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer. PMID: 21860067 Ref: Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro. PMID: 21940310 Ref: Hedgehog signaling and the Gli code in stem cells, cancer, and metastases. PMID: 22114144 |
Ref: Prognostic value of hedgehog signaling pathway in patients with colon cancer. PMID: 21424326 Ref: Abrogation of Gli3 expression suppresses the growth of colon cancer cells via activation of p53. PMID: 22227409 Ref: Folate deprivation enhances invasiveness of human colon cancer cells mediated by activation of sonic hedgehog signaling through promoter hypomethylation and cross action with transcription nuclear factor-kappa B pathway. PMID: 22461522 Ref: Expression of glioma-associated oncogene homolog 1 is associated with invasion and postoperative liver metastasis in colon cancer. PMID: 22745574 Ref: Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer. PMID: 22859707 Ref: Expression and clinical significance of hedgehog signaling pathway related components in colorectal cancer. PMID: 22901214 Ref: Hedgehog pathway signaling regulates human colon carcinoma HT-29 epithelial cell line apoptosis and cytokine secretion. PMID: 23028941 Ref: Regulation of DNA damage following termination of Hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer. PMID: 23097684 Ref: Expression of smoothened protein in colon cancer and its prognostic value for postoperative liver metastasis. PMID: 23098507 |
Ref: Aberrant methylation of the PTCH1 gene promoter region in aberrant crypt foci. PMID: 22945423 Ref: Expression of GLI1 correlates with expression of lymphangiogenesis proteins, vascular endothelial growth factor C and vascular endothelial growth factor receptor 3, in colorectal cancer. PMID: 23336661 Ref: Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coli. PMID: 23551431 Ref: Structural and logical analysis of a comprehensive hedgehog signaling pathway to identify alternative drug targets for glioma, colon and pancreatic cancer. PMID: 23935937 Ref: Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells. PMID: 24086482 Ref: A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis. PMID: 24368541 |
Ref: Association of common gene variants in the WNT/beta-catenin pathway with colon cancer recurrence. PMID: 23817222 Ref: A functional germline variant in GLI1 implicates hedgehog signaling in clinical outcome of stage II and III colon carcinoma patients. PMID: 24470513 Ref: Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding. PMID: 24962990 Ref: Hedgehog-glioma-associated oncogene homolog-1 signaling in colon cancer cells and its role in the celecoxib-mediated anti-cancer effect. PMID: 25295109 Ref: p, p'-Dichlorodiphenyldichloroethylene induces colorectal adenocarcinoma cell proliferation through oxidative stress. PMID: 25386960 |
Ref: beta1 integrin mediates colorectal cancer cell proliferation and migration through regulation of the Hedgehog pathway. PMID: 25387809 Ref: Phase I dose-escalation trial of the oral investigational Hedgehog signaling pathway inhibitor TAK-441 in patients with advanced solid tumors. PMID: 25501576 Ref: Crosstalk between Wnt/beta-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy. PMID: 25692617 Ref: Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002. PMID: 25945059 Ref: GSK3beta and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer - Targeting GSK3beta downregulates the signaling pathway and reduces cell proliferation. PMID: 26385428 Ref: Inhibition of SALL4 suppresses carcinogenesis of colorectal cancer via regulating Gli1 expression. PMID: 26617716 Ref: Dysregulation of hedgehog signaling pathway related components in the evolution of colonic carcinogenesis. PMID: 26885080 |
Ref: In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases. PMID: 26031752 Ref: Arsenic Attenuates GLI Signaling, Increasing or Decreasing its Transcriptional Program in a Context-Dependent Manner. PMID: 26573582 Ref: Inhibition of GLI1 Expression by Targeting the CRD-BP-GLI1 mRNA Interaction Using a Specific Oligonucleotide. PMID: 27036131 Ref: Neoexpression of a functional primary cilium in colorectal cancer cells. PMID: 27441280 Ref: Knockdown of PFTAIRE Protein Kinase 1 (PFTK1) Inhibits Proliferation, Invasion, and EMT in Colon Cancer Cells. PMID: 27458094 Ref: Gli1 promotes colorectal cancer metastasis in a Foxm1-dependent manner by activating EMT and PI3K-AKT signaling. PMID: 27863385 Ref: Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing. PMID: 27863397 Ref: Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer. PMID: 27894099 Ref: The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells. PMID: 27917272 |
Ref: Aberrant activation of hedgehog signaling promotes cell proliferation via the transcriptional activation of forkhead Box M1 in colorectal cancer cells. PMID: 28148279 Ref: Identification of Diverse Adenosine-to-Inosine RNA Editing Subtypes in Colorectal Cancer. PMID: 28161934 Ref: The role of GLI1 for 5-Fu resistance in colorectal cancer. PMID: 28413604 Ref: FOXR2 Promotes the Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Human Colorectal Cancer Cells. PMID: 28548041 Ref: Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines. PMID: 28565875 Ref: Evaluation of cytotoxic and antitumoral properties of Tessaria absinthioides (Hook & Arn) DC, "pajaro bobo", aqueous extract. PMID: 28825571 Ref: Low folate metabolic stress reprograms DNA methylation-activated sonic hedgehog signaling to mediate cancer stem cell-like signatures and invasive tumour stage-specific malignancy of human colorectal cancers. PMID: 28833104 Ref: Zhi Zhen Fang formula reverses Hedgehog pathway mediated multidrug resistance in colorectal cancer. PMID: 28849164 Ref: Bromopropane Compounds Increase the Stemness of Colorectal Cancer Cells. PMID: 28862656 Ref: MiR-150 alleviates EMT and cell invasion of colorectal cancer through targeting Gli1. PMID: 29164577 Ref: Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells. PMID: 29212028 Ref: Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway. PMID: 29254217 Ref: SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer. PMID: 29456503 |
Ref: Intratumoral Heterogeneity of Frameshift Mutations of GLI1 Encoding a Hedgehog Signaling Protein in Colorectal Cancers. PMID: 28664474 Ref: Pseudopod-associated protein KIF20B promotes Gli1-induced epithelial-mesenchymal transition modulated by pseudopodial actin dynamic in human colorectal cancer. PMID: 29573464 Ref: Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture. PMID: 29642386 Ref: The influence of aberrant expression of GLI1/p-S6K on colorectal cancer. PMID: 30143258 Ref: Cell fate in colon cancer stem cells: To GLI or not to GLI? PMID: 30250897 |