Primary Site >> Colorectal Cancer
Gene >> GCLC
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Ref: Influence of ethacrynic acid on glutathione S-transferase pi transcript and protein half-lives in human colon cancer cells. PMID: 7488239 |
Ref: Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers. PMID: 8705999 Ref: Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz. PMID: 8787684 |
Ref: Frequent coexpression of MRP/GS-X pump and gamma-glutamylcysteine synthetase mRNA in drug-resistant cells, untreated tumor cells, and normal mouse tissues. PMID: 9515571 |
Ref: The human multidrug resistance-associated protein (MRP) gene family: from biological function to drug molecular design. PMID: 11097346 |
Ref: Differential sensitivities of the MRP gene family and gamma-glutamylcysteine synthetase to prooxidants in human colorectal carcinoma cell lines with different p53 status. PMID: 11239498 Ref: Reversal of cisplatin and multidrug resistance by ribozyme-mediated glutathione suppression. PMID: 11500053 |
Ref: Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma-GCSh) in human colorectal carcinoma. PMID: 11774239 Ref: Red wine and black tea polyphenols modulate the expression of cycloxygenase-2, inducible nitric oxide synthase and glutathione-related enzymes in azoxymethane-induced f344 rat colon tumors. PMID: 12042461 |
Ref: Calvatia lilacina protein-extract induces apoptosis through glutathione depletion in human colorectal carcinoma cells. PMID: 19182949 |
Ref: The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells. PMID: 20657484 |
Ref: Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. PMID: 21256954 |
Ref: Involvement of glutathione and glutathione metabolizing enzymes in human colorectal cancer cell lines and tissues. PMID: 26059756 |
Ref: The proteasome inhibitor lactacystin enhances GSH synthesis capacity by increased expression of antioxidant components in an Nrf2-independent, but p38 MAPK-dependent manner in rat colorectal carcinoma cells. PMID: 26530909 Ref: PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis. PMID: 26784545 Ref: Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer. PMID: 27323826 Ref: Colonic Lamina Propria Inflammatory Cells from Patients with IBD Induce the Nuclear Factor-E2 Related Factor-2 Thereby Leading to Greater Proteasome Activity and Apoptosis Protection in Human Colonocytes. PMID: 27661668 |