Primary Site >> Liver Cancer
Gene >> GADD45B
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Ref: Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643. PMID: 12727805 Ref: Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma. PMID: 12759252 |
Ref: Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma. PMID: 15509538 |
Ref: Unique patterns of gene expression changes in liver after treatment of mice for 2 weeks with different known carcinogens and non-carcinogens. PMID: 15618236 |
Ref: The putative tumor suppressor Tsc-22 is downregulated early in chemically induced hepatocarcinogenesis and may be a suppressor of Gadd45b. PMID: 17533171 Ref: The induction of growth arrest DNA damage-inducible gene 45 beta in human hepatoma cell lines by S-adenosylmethionine. PMID: 17591973 Ref: Interferon-gamma sensitizes hepatitis B virus-expressing hepatocarcinoma cells to 5-fluorouracil through inhibition of hepatitis B virus-mediated nuclear factor-kappaB activation. PMID: 17711513 Ref: A sequential treatment of depsipeptide followed by 5-azacytidine enhances Gadd45beta expression in hepatocellular carcinoma cells. PMID: 18225533 |
Ref: Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT. PMID: 18925944 |
Ref: The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors. PMID: 19482888 |
Ref: Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B. PMID: 20404936 Ref: Induction of DNA damage-inducible gene GADD45beta contributes to sorafenib-induced apoptosis in hepatocellular carcinoma cells. PMID: 21062976 |
Ref: Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration. PMID: 21127053 Ref: Involvement of the NF-kappaB pathway in multidrug resistance induced by HBx in a hepatoma cell line. PMID: 21914061 |
Ref: In-silico drug screening and potential target identification for hepatocellular carcinoma using Support Vector Machines based on drug screening result. PMID: 23220021 Ref: Dichlorodiphenyltrichloroethane technical mixture regulates cell cycle and apoptosis genes through the activation of CAR and ERalpha in mouse livers. PMID: 23684557 Ref: Interferon-alpha sensitizes HBx-expressing hepatocarcinoma cells to chemotherapeutic drugs through inhibition of HBx-mediated NF-kappaB activation. PMID: 23718853 Ref: Cylindrospermopsin induced transcriptional responses in human hepatoma HepG2 cells. PMID: 23726867 Ref: Gadd45 in the liver: signal transduction and transcriptional mechanisms. PMID: 24104474 |
Ref: Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis. PMID: 23888939 Ref: Overexpression of the transcription factor MEF2D in hepatocellular carcinoma sustains malignant character by suppressing G2-M transition genes. PMID: 24390737 Ref: Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver. PMID: 25145657 Ref: Altered gene expression in HepG2 cells exposed to a methanolic coal dust extract. PMID: 25305735 |
Ref: Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7. PMID: 27134688 Ref: GADD45beta induction by S-adenosylmethionine inhibits hepatocellular carcinoma cell proliferation during acute ischemia-hypoxia. PMID: 27177086 |
Ref: Simultaneous silencing of ACSL4 and induction of GADD45B in hepatocellular carcinoma cells amplifies the synergistic therapeutic effect of aspirin and sorafenib. PMID: 28900541 Ref: Methylation mediated Gadd45beta enhanced the chemosensitivity of hepatocellular carcinoma by inhibiting the stemness of liver cancer cells. PMID: 29225771 |
Ref: GADD45beta Loss Ablates Innate Immunosuppression in Cancer. PMID: 29279355 Ref: Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver. PMID: 29716964 Ref: GADD45B as a Prognostic and Predictive Biomarker in Stage II Colorectal Cancer. PMID: 30029519 Ref: Constitutive Activation of the Human Aryl Hydrocarbon Receptor in Mice Promotes Hepatocarcinogenesis Independent of Its Coactivator Gadd45b. PMID: 30346592 |