Primary Site >> Colorectal Cancer
Gene >> GADD45A
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Ref: The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein. PMID: 8522347 |
Ref: An abnormality in the p53 pathway following gamma-irradiation in many wild-type p53 human melanoma lines. PMID: 8631022 Ref: Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines. PMID: 8938795 Ref: Antisense GADD45 expression results in decreased DNA repair and sensitizes cells to u.v.-irradiation or cisplatin. PMID: 8950993 |
Ref: The p53-regulated cyclin G gene promotes cell growth: p53 downstream effectors cyclin G and Gadd45 exert different effects on cisplatin chemosensitivity. PMID: 9013707 |
Ref: Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses. PMID: 11431359 |
Ref: Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells. PMID: 12406558 Ref: Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction. PMID: 12477050 |
Ref: Effect of selenium-enriched broccoli diet on differential gene expression in min mouse liver(1,2). PMID: 12770647 Ref: [Gene-regulating chemoprevention against cancer--as a model for "molecular-targeting prevention" of cancer]. PMID: 12806965 Ref: Down-regulation of proliferating cell nuclear antigen gene expression occurs during cell cycle arrest induced by human fecal water in colonic HT-29 cells. PMID: 12888658 Ref: Induction of GADD gene expression by phenethylisothiocyanate in human colon adenocarcinoma cells. PMID: 14635187 Ref: [Suppression of HCT116 growth of cells by Gadd45]. PMID: 14642075 |
Ref: Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil. PMID: 15067352 Ref: Cell cycle-related signaling pathways modulated by peripheral benzodiazepine receptor ligands in colorectal cancer cells. PMID: 15474510 |
Ref: 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. PMID: 15547111 Ref: Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway. PMID: 15956247 Ref: Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells. PMID: 15961301 Ref: Differential gene expression of sulindac-treated human breast epithelial cells. PMID: 16273229 |
Ref: Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. PMID: 16709241 Ref: cDNA array analysis for prediction of hepatic metastasis of colorectal carcinoma. PMID: 16794795 |
Ref: Base excision DNA repair defect in Gadd45a-deficient cells. PMID: 17599061 |
Ref: Cell kinetics and gene expression changes in colorectal cancer patients given resistant starch: a randomised controlled trial. PMID: 18978177 Ref: Distinct mechanisms are utilized to induce stress sensor gadd45b by different stress stimuli. PMID: 19834918 |
Ref: Differential antineoplastic effects of butyrate in cells with and without a functioning DNA mismatch repair. PMID: 20043265 Ref: Semi-quantitative detection of GADD45-gamma methylation levels in gastric, colorectal and pancreatic cancers using methylation-sensitive high-resolution melting analysis. PMID: 20111973 Ref: Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition? PMID: 20444249 |
Ref: Differential expression of senescence and cell death factors in non-small cell lung and colorectal tumors showing telomere attrition. PMID: 22433385 Ref: N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents. PMID: 22801474 Ref: Non-digestible fraction of beans (Phaseolus vulgaris L.) modulates signalling pathway genes at an early stage of colon cancer in Sprague-Dawley rats. PMID: 22916810 |
Ref: Expression of cell cycle regulatory factors hus1, gadd45a, rb1, cdkn2a and mre11a correlates with expression of clock gene per2 in human colorectal carcinoma tissue. PMID: 24062075 |
Ref: Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38alpha modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A. PMID: 24215867 Ref: Growth hormone protects colorectal cancer cells from radiation by improving the ability of DNA damage repair. PMID: 24788673 |
Ref: Correction to "5-aza-Cytidine Is a Potent Inhibitor of DNA Methyltransferase 3a and Induces Apoptosis in HCT-116 Colon Cancer Cells via Gadd45- and p53-Dependent Mechanisms". PMID: 25934763 Ref: MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression. PMID: 26003165 |
Ref: Re: Schneider-Stock R, Diab-Assef M, Rohrbeck A, Foltzer-Jourdainne C, Boltze C, Hartig R, Schonfeld P, Roessner A, and Gali-Muhtasib H (2005) 5-aza-Cytidine Is a Potent Inhibitor of DNA Methyltransferase 3a and Induces Apoptosis in HCT-116 Colon Cancer C PMID: 27581647 Ref: Arsenic trioxide induces cell cycle arrest and alters DNA methylation patterns of cell cycle regulatory genes in colorectal cancer cells. PMID: 27769816 |
Ref: CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45. PMID: 28068431 Ref: CRIF1 enhances p53 activity via the chromatin remodeler SNF5 in the HCT116 colon cancer cell lines. PMID: 28235567 |
Ref: Baicalein induces the apoptosis of HCT116 human colon cancer cells via the upregulation of DEPP/Gadd45a and activation of MAPKs. PMID: 29749481 Ref: The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1. PMID: 29966255 |