Primary Site >> Liver Cancer

Gene >> G6PC

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Ref: Case report: Hepatocellular carcinoma in type 1a glycogen storage disease with identification of a glucose-6-phosphatase gene mutation in one family.
PMID: 10385064
Ref: Glucose-6-phosphatase gene mutations in 20 adult Japanese patients with glycogen storage disease type 1a with reference to hepatic tumors.
PMID: 11851840
Ref: An adult male patient with multiple adenomas and a hepatocellular carcinoma: mild glycogen storage disease type Ia.
PMID: 20447711
Ref: Abdominal imaging findings of a patient with hepatocellular carcinoma associated with glycogen storage disease type 1a.
PMID: 22001457
Ref: Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.
PMID: 22318941
Ref: Misdiagnosis as steatohepatitis in a family with mild glycogen storage disease type 1a.
PMID: 22909800
Ref: Development of hepatocellular adenomas and carcinomas in mice with liver-specific G6Pase-alpha deficiency.
PMID: 25147298
Ref: mTORC2 controls cancer cell survival by modulating gluconeogenesis.
PMID: 27551450
Ref: Glycogen storage disease type Ia mice with less than 2% of normal hepatic glucose-6-phosphatase-alpha activity restored are at risk of developing hepatic tumors.
PMID: 28096054
Ref: Recent development and gene therapy for glycogen storage disease type Ia.
PMID: 29576889
Ref: Hepatic glucose-6-phosphatase-alpha deficiency leads to metabolic reprogramming in glycogen storage disease type Ia.
PMID: 29545180
Ref: Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context.
PMID: 30100243
Ref: Dietary exacerbation of metabolic stress leads to accelerated hepatic carcinogenesis in glycogen storage disease type Ia.
PMID: 30193922