Primary Site >> Colorectal Cancer
Gene >> FURIN
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Ref: A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells. PMID: 7690548 Ref: Evidence for involvement of furin in cleavage and activation of diphtheria toxin. PMID: 8253774 Ref: Proteolytic processing of the hepatocyte growth factor/scatter factor receptor by furin. PMID: 8344430 Ref: Reimbursement issues facing patients, providers, and payers. PMID: 8402516 |
Ref: A second mutant allele of furin in the processing-incompetent cell line, LoVo. Evidence for involvement of the homo B domain in autocatalytic activation. PMID: 7592877 Ref: Direct role of furin in mammalian prosomatostatin processing. PMID: 7619075 Ref: Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus. PMID: 7707552 |
Ref: Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors. PMID: 10706098 Ref: Physical activity and cause-specific mortality in the Whitehall study. PMID: 11035446 |
Ref: Genetic predisposition and somatic diversification in tumor development and progression. PMID: 11034541 Ref: Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions. PMID: 11402025 |
Ref: Does virtual colonoscopy have a major role in population-based screening? PMID: 11916164 Ref: Matrix metalloproteinase-21, the human orthologue for XMMP, is expressed during fetal development and in cancer. PMID: 12490321 |
Ref: The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity. PMID: 12670890 Ref: Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage. PMID: 12691605 Ref: The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis. PMID: 12782675 |
Ref: Prointegrin maturation follows rapid trafficking and processing of MT1-MMP in Furin-Negative Colon Carcinoma LoVo Cells. PMID: 15260832 |
Ref: Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin. PMID: 15381157 Ref: Adjuvant therapy for colon cancer--the pace quickens. PMID: 15987925 Ref: Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development. PMID: 16163737 Ref: Proteolytic processing of the ovine prion protein in cell cultures. PMID: 16182247 Ref: A preclinical survey on the efficacy of lactandrate in the treatment of colon carcinoma. PMID: 17343334 |
Ref: [Future direction of nanomedicine in gastrointestinal cancer]. PMID: 17525514 Ref: Proteolytic cleavage of glycoprotein B is dispensable for in vitro replication, but required for syncytium formation of pseudorabies virus. PMID: 17554016 |
Ref: Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells. PMID: 18064302 Ref: Colorectal cancer cells express functional cell surface-bound TGFbeta. PMID: 18076044 |
Ref: Autocatalytic activation of the furin zymogen requires removal of the emerging enzyme's N-terminus from the active site. PMID: 19352504 Ref: Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma. PMID: 19380613 |
Ref: Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression. PMID: 19998449 Ref: Walking pace, leisure time physical activity, and resting heart rate in relation to disease-specific mortality in London: 40 years follow-up of the original Whitehall study. An update of our work with professor Jerry N. Morris (1910-2009). PMID: 20579904 |
Ref: 2A peptide-based, lentivirus-mediated anti-death receptor 5 chimeric antibody expression prevents tumor growth in nude mice. PMID: 21934654 Ref: Understanding molecular mechanisms in peritoneal dissemination of colorectal cancer : future possibilities for personalised treatment by use of biomarkers. PMID: 22825001 |
Ref: beta-Catenin-dependent lysosomal targeting of internalized tumor necrosis factor-alpha suppresses caspase-8 activation in apoptosis-resistant colon cancer cells. PMID: 23264463 Ref: Virtual navigation in colorectal cancer and melanoma: an exploration of patients' views. PMID: 23519565 Ref: Functional genomic analyses of the gut microbiota for CRC screening. PMID: 24042452 Ref: Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface. PMID: 24145028 |
Ref: Comparison of plasma levels of nutrient-related biomarkers among Japanese populations in Tokyo, Japan, Sao Paulo, Brazil, and Hawaii, USA. PMID: 25633435 Ref: Single Nucleotide Polymorphism (rs4932178) in the P1 Promoter of FURIN Is Not Prognostic to Colon Cancer. PMID: 26137475 |
Ref: Contribution of changes in demography and in the risk factors to the predicted pattern of cancer mortality among Spanish women by 2022. PMID: 26707236 |
Ref: Long noncoding RNA BLACAT1 indicates a poor prognosis of colorectal cancer and affects cell proliferation by epigenetically silencing of p15. PMID: 28277544 |
Ref: Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis. PMID: 29867200 Ref: Semaphorin-3A inhibits multiple myeloma progression in a mouse model. PMID: 30102336 |