Primary Site >> Colorectal Cancer
Gene >> FPGS
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Ref: Screening of colon tumor cells and tissues for folylpolyglutamate synthetase activity. PMID: 8527866 Ref: Folate-based thymidylate synthase inhibitors as anticancer drugs. PMID: 8624289 |
Ref: Critical factors for optimizing the 5-fluorouracil-folinic acid association in cancer chemotherapy. PMID: 8740793 Ref: Resistance to tomudex (ZD1694): multifactorial in human breast and colon carcinoma cell lines. PMID: 8787551 Ref: Tomudex (ZD1694): from concept to care, a programme in rational drug discovery. PMID: 8958186 |
Ref: Folate-based thymidylate synthase inhibitors in cancer chemotherapy. PMID: 9147608 Ref: Decreased folylpolyglutamate synthetase activity in tumors resistant to fluorouracil-folinic acid treatment: clinical data. PMID: 9815719 |
Ref: Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines. PMID: 10100718 Ref: Enzyme inhibition, polyglutamation, and the effect of LY231514 (MTA) on purine biosynthesis. PMID: 10598554 Ref: Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene expression in human colorectal tumors. PMID: 10821538 |
Ref: Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates. PMID: 10956384 |
Ref: Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression. PMID: 12907242 Ref: Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients. PMID: 14676127 |
Ref: Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate. PMID: 15542523 |
Ref: Variance in the expression of 5-Fluorouracil pathway genes in colorectal cancer. PMID: 15814641 Ref: Low expression of reduced folate carrier-1 and folylpolyglutamate synthase correlates with lack of a deleted in colorectal carcinoma mRNA splice variant in normal-appearing mucosa of colorectal carcinoma patients. PMID: 16122883 |
Ref: Tumor quantification of several fluoropyrimidines resistance gene expression with a unique quantitative RT-PCR method. Implications for pretherapeutic determination of tumor resistance phenotype. PMID: 16387426 Ref: Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer. PMID: 16512993 |
Ref: Colorectal carcinomas with microsatellite instability display increased thymidylate synthase gene expression levels. PMID: 18039426 |
Ref: Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity. PMID: 18035049 Ref: p16INK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancer. PMID: 18418463 Ref: Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations. PMID: 18842806 |
Ref: Molecular determinants of folate levels after leucovorin administration in colorectal cancer. PMID: 19636555 Ref: Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines. PMID: 20020129 Ref: Genes involved with folate uptake and distribution and their association with colorectal cancer risk. PMID: 20037791 |
Ref: In vivo evidence for a significant role of folylpolyglutamate synthase in combined chemotherapy with oral fluoropyrimidine, UFT or S-1, and leucovorin. PMID: 21380490 |
Ref: Analysis of the mRNA expression of chemotherapy-related genes in colorectal carcinoma using the danenberg tumor profile method. PMID: 23577026 |
Ref: Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis. PMID: 26676887 Ref: Do we need colonoscopy verification in patients with fundic gland polyp? PMID: 27175118 |
Ref: Relationship between folate concentration and expression of folate-associated genes in tissue and plasma after intraoperative administration of leucovorin in patients with colorectal cancer. PMID: 30269276 |