Primary Site >> Colorectal Cancer
Gene >> FOXO3
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Ref: Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. PMID: 11884591 |
Ref: Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil. PMID: 15067352 Ref: MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress. PMID: 15322085 |
Ref: Mutant PIK3CA promotes cell growth and invasion of human cancer cells. PMID: 15950905 |
Ref: Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. PMID: 17452451 Ref: Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. PMID: 17615082 |
Ref: Wnt signaling inhibits Forkhead box O3a-induced transcription and apoptosis through up-regulation of serum- and glucocorticoid-inducible kinase 1. PMID: 18487207 Ref: G0 cell cycle arrest alone is insufficient for enabling the repair of ionizing radiation-induced potentially lethal damage. PMID: 18666809 Ref: LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins. PMID: 18794113 Ref: FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells. PMID: 18852127 Ref: [A lentivirus vector based assay system for quantitative detection of intracellular translocations of recombinant proteins]. PMID: 19140320 |
Ref: p38alpha blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1alpha- to FoxO-dependent transcription. PMID: 19343039 Ref: Role of microRNA-143 in Fas-mediated apoptosis in human T-cell leukemia Jurkat cells. PMID: 19464056 Ref: Relative resistance of SGK1 knockout mice against chemical carcinogenesis. PMID: 19548318 Ref: Inhibition of p38alpha unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism. PMID: 19587525 Ref: Role of prosurvival molecules in the action of lidamycin toward human tumor cells. PMID: 19725468 Ref: A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways. PMID: 19767770 |
Ref: p38alpha is required for ovarian cancer cell metabolism and survival. PMID: 20169663 Ref: Colorectal carcinoma cells--regulation of survival and growth by SGK1. PMID: 20541034 |
Ref: Tumor suppressor FOXO3 mediates signals from the EGF receptor to regulate proliferation of colonic cells. PMID: 21109589 Ref: Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity. PMID: 21639915 |
Ref: Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models. PMID: 22579651 Ref: FOXO3a and beta-catenin co-localization: double trouble in colon cancer? PMID: 22673992 Ref: Nuclear accumulation of beta-catenin and forkhead box O3a in colon cancer: Dangerous liaison. PMID: 23024836 |
Ref: Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a. PMID: 22978663 Ref: PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells. PMID: 23392169 Ref: Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions. PMID: 23434653 Ref: Coexistent mutations of KRAS and PIK3CA affect the efficacy of NVP-BEZ235, a dual PI3K/MTOR inhibitor, in regulating the PI3K/MTOR pathway in colorectal cancer. PMID: 23475782 Ref: Remarkably reduced expression of FoxO3a in metaplastic colorectum, primary colorectal cancer and liver metastasis. PMID: 23592131 Ref: FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density. PMID: 23603907 Ref: DTNQ-Pro, a Mimetic Dipeptide, Sensitizes Human Colon Cancer Cells to 5-Fluorouracil Treatment. PMID: 23710334 Ref: Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors. PMID: 23732517 Ref: FOXO3 expression during colorectal cancer progression: biomarker potential reflects a tumour suppressor role. PMID: 23828518 Ref: Decreased FOXO3 within advanced human colon cancer: implications of tumour suppressor function. PMID: 23828519 Ref: microRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2. PMID: 23846336 Ref: miR-153 supports colorectal cancer progression via pleiotropic effects that enhance invasion and chemotherapeutic resistance. PMID: 23950211 |
Ref: SPROUTY2 is a beta-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer. PMID: 23624922 Ref: Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38alpha modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A. PMID: 24215867 Ref: Revealing the molecular mechanism of colorectal cancer by establishing LGALS3-related protein-protein interaction network and identifying signaling pathways. PMID: 24398765 Ref: ZIC1 is a putative tumor suppressor in thyroid cancer by modulating major signaling pathways and transcription factor FOXO3a. PMID: 24684457 Ref: Differential expression of miRNAs in colon cancer between African and Caucasian Americans: implications for cancer racial health disparities. PMID: 24865442 Ref: Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation. PMID: 24953710 Ref: [Changes of expression of miR-155 in colitis-associated colonic carcinogenesis]. PMID: 24989910 Ref: FOXC2 promotes colorectal cancer proliferation through inhibition of FOXO3a and activation of MAPK and AKT signaling pathways. PMID: 25069037 Ref: Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR. PMID: 25389372 Ref: Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia. PMID: 25539728 |
Ref: MicroRNA-96 promotes the proliferation of colorectal cancer cells and targets tumor protein p53 inducible nuclear protein 1, forkhead box protein O1 (FOXO1) and FOXO3a. PMID: 25369914 Ref: Quinazoline based small molecule exerts potent tumour suppressive properties by inhibiting PI3K/Akt/FoxO3a signalling in experimental colon cancer. PMID: 25554016 Ref: The DEAD box protein p68: a crucial regulator of AKT/FOXO3a signaling axis in oncogenesis. PMID: 25745998 Ref: Epibrassinolide alters PI3K/MAPK signaling axis via activating Foxo3a-induced mitochondria-mediated apoptosis in colon cancer cells. PMID: 26318418 Ref: miR-451 regulates FoxO3 nuclear accumulation through Ywhaz in human colorectal cancer. PMID: 26885274 |
Ref: Tankyrase Inhibition Blocks Wnt/beta-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer. PMID: 26224873 Ref: Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6. PMID: 26657850 Ref: Resveratrol-induced transcriptional up-regulation of ASMase (SMPD1) of human leukemia and cancer cells. PMID: 26809095 Ref: Inhibition of colon cancer growth by docosahexaenoic acid involves autocrine production of TNFalpha. PMID: 26853468 Ref: PS341 inhibits hepatocellular and colorectal cancer cells through the FOXO3/CTNNB1 signaling pathway. PMID: 26915315 Ref: Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways. PMID: 27004568 Ref: An oncogenic role of miR-592 in tumorigenesis of human colorectal cancer by targeting Forkhead Box O3A (FoxO3A). PMID: 27167185 Ref: Histone deacetylase inhibitors regulate P-gp expression in colorectal cancer via transcriptional activation and mRNA stabilization. PMID: 27409663 Ref: Inactivation of the FoxO3a transcription factor is associated with the production of reactive oxygen species during protein kinase CK2 downregulation-mediated senescence in human colon cancer and breast cancer cells. PMID: 27470586 Ref: FOXO3a and the MAPK p38 are activated by cetuximab to induce cell death and inhibit cell proliferation and their expression predicts cetuximab efficacy in colorectal cancer. PMID: 27685445 Ref: FoxO3a confers cetuximab resistance in RAS wild-type metastatic colorectal cancer through c-Myc. PMID: 27825133 |
Ref: cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium. PMID: 27998725 Ref: Inflammatory hypoxia induces syndecan-2 expression through IL-1beta-mediated FOXO3a activation in colonic epithelia. PMID: 28031321 Ref: REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival. PMID: 28055019 Ref: Assessment of histone tail modifications and transcriptional profiling during colon cancer progression reveals a global decrease in H3K4me3 activity. PMID: 28315775 Ref: MicroRNA-608 inhibits proliferation of bladder cancer via AKT/FOXO3a signaling pathway. PMID: 28549468 Ref: NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer. PMID: 28598238 Ref: PTEN/FOXO3/AKT pathway regulates cell death and mediates morphogenetic differentiation of Colorectal Cancer Cells under Simulated Microgravity. PMID: 28729699 Ref: XB130 enhances invasion and migration of human colorectal cancer cells by promoting epithelialmesenchymal transition. PMID: 28849225 Ref: Involvement of miR-155/FOXO3a and miR-222/PTEN in acquired radioresistance of colorectal cancer cell line. PMID: 28879560 Ref: Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival. PMID: 28936799 |
Ref: Simvastatin enhances the radiosensitivity of p53deficient cells via inhibition of mouse double minute 2 homolog. PMID: 29115437 Ref: Knockdown of the long non-coding RNA HOTTIP inhibits colorectal cancer cell proliferation and migration and induces apoptosis by targeting SGK1. PMID: 29274585 Ref: Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells. PMID: 29301589 Ref: MicroRNA-155 increases colon cancer chemoresistance to cisplatin by targeting forkhead box O3. PMID: 29552117 Ref: SP1 upregulated FoxO3a promotes tumor progression in colorectal cancer. PMID: 29565456 Ref: Pristimerin, a naturally occurring triterpenoid, attenuates tumorigenesis in experimental colitis-associated colon cancer. PMID: 29655682 Ref: Genistein and daidzein induce apoptosis of colon cancer cells by inhibiting the accumulation of lipid droplets. PMID: 29849534 Ref: Effects of miR-223 on colorectal cancer cell proliferation and apoptosis through regulating FoxO3a/BIM. PMID: 29949152 Ref: RORgammat-Expressing Tregs Drive the Growth of Colitis-Associated Colorectal Cancer by Controlling IL6 in Dendritic Cells. PMID: 29991500 Ref: High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway. PMID: 30064475 Ref: lncRNA GAS5 inhibits colorectal cancer cell proliferation via the miR1825p/FOXO3a axis. PMID: 30066886 |