Primary Site >> Colorectal Cancer
Gene >> FOSL1
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Ref: Requirement of an upstream AP-1 motif for the constitutive and phorbol ester-inducible expression of the urokinase-type plasminogen activator receptor gene. PMID: 8798512 |
Ref: Targeted disruption of the K-ras oncogene in an invasive colon cancer cell line down-regulates urokinase receptor expression and plasminogen-dependent proteolysis. PMID: 10471035 |
Ref: Bile acid-induced activation of activator protein-1 requires both extracellular signal-regulated kinase and protein kinase C signaling. PMID: 10748108 |
Ref: A possible role for the WNT-1 pathway in oral carcinogenesis. PMID: 11345525 |
Ref: Activation of the Wnt pathway interferes with serum response element-driven transcription of immediate early genes. PMID: 11751871 Ref: Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage. PMID: 12023887 Ref: Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin. PMID: 12209953 |
Ref: Expression profiling of CC531 colon carcinoma cells reveals similar regulation of beta-catenin target genes by both butyrate and aspirin. PMID: 12800193 Ref: ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. PMID: 12892714 Ref: Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells. PMID: 14625389 |
Ref: Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells. PMID: 15735008 Ref: Differential expression of the AP-1 transcription factor family members in human colorectal epithelial and neuroendocrine neoplasms. PMID: 15923159 Ref: The Fos family of transcription factors and their role in tumourigenesis. PMID: 16199154 Ref: Galectin-3 modulates MUC2 mucin expression in human colon cancer cells at the level of transcription via AP-1 activation. PMID: 16285957 Ref: Combination analysis of activator protein-1 family members, Sp1 and an activator protein-2alpha-related factor binding to different regions of the urokinase receptor gene in resected colorectal cancers. PMID: 16361535 |
Ref: Aspirin upregulates expression of urokinase type plasminogen activator receptor (uPAR) gene in human colon cancer cells through AP1. PMID: 16893520 |
Ref: Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer. PMID: 17510314 Ref: Involvement of RNA helicases p68 and p72 in colon cancer. PMID: 17699760 |
Ref: Fra-1 regulates vimentin during Ha-RAS-induced epithelial mesenchymal transition in human colon carcinoma cells. PMID: 18098284 Ref: The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice. PMID: 18679426 |
Ref: MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1. PMID: 22198213 Ref: Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways. PMID: 22419013 |
Ref: EZH2 is regulated by ERK/AKT and targets integrin alpha2 gene to control Epithelial-Mesenchymal Transition and anoikis in colon cancer cells. PMID: 23116973 |
Ref: Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells. PMID: 24658684 Ref: Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. PMID: 24936217 |
Ref: Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial-mesenchymal transition. PMID: 25750173 Ref: Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival. PMID: 26646695 |
Ref: SIRT1 promotes epithelial-mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression. PMID: 26975631 Ref: miR-497 suppresses epithelial-mesenchymal transition and metastasis in colorectal cancer cells by targeting fos-related antigen-1. PMID: 27822064 |
Ref: [Spleen tyrosine kinase inhibits proliferation and promotes apoptosis of colorectal cancer cells in vitro via regulating Fra-1]. PMID: 29292261 |
Ref: Fra1 enhances the radioresistance of colon cancer cells to Xray or Cion radiation. PMID: 29399696 Ref: The Endosomal Protein CEMIP Links WNT Signaling to MEK1-ERK1/2 Activation in Selumetinib-Resistant Intestinal Organoids. PMID: 29915160 |