Primary Site >> Colorectal Cancer
Gene >> FOS
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Ref: Prognostic implications of expression of the cellular genes myc, fos, Ha-ras and Ki-ras in colon carcinoma. PMID: 3040597 |
Ref: Differential expression of c-myc gene and c-fos gene in premalignant and malignant tissues from patients with familial polyposis coli. PMID: 2842040 Ref: [Oncogene expression in colonic cancers]. PMID: 3051685 Ref: Oncogene expression in adenocarcinomas of the colon and in colon tumor-derived cell lines. PMID: 3282475 Ref: Biological characterization and oncogene expression in human colorectal carcinoma cell lines. PMID: 3338874 |
Ref: Polyamines differentially modulate the transcription of growth-associated genes in human colon carcinoma cells. PMID: 2498320 Ref: Modulation of growth gene expression by selective alteration of polyamines in human colon carcinoma cells. PMID: 2511847 Ref: Overexpression of DNA replication and repair enzymes in cisplatin-resistant human colon carcinoma HCT8 cells and circumvention by azidothymidine. PMID: 2534792 Ref: Expression of c-myc oncogene in colorectal polyps as a biological marker for monitoring malignant potential. PMID: 2743265 |
Ref: Expression of c-myc and c-fos mRNA in colorectal carcinoma in man. PMID: 1980763 Ref: Changes in c-myc and c-fos expression in a human tumor cell line following exposure to bifunctional alkylating agents. PMID: 2104539 Ref: Differential oncogene amplification in tumor cells from a patient treated with cisplatin and 5-fluorouracil. PMID: 2141497 |
Ref: The trk family of oncogenes and neurotrophin receptors. PMID: 1844238 Ref: [Diagnosis of colorectal cancer from DNA level]. PMID: 1846282 Ref: Enhanced expression of oncogene-encoded mRNA in a rat model of colon cancer. PMID: 2012108 |
Ref: Association of genetic alterations of c-myc, c-fos, and c-Ha-ras proto-oncogenes in colorectal tumors. Frequency and clinical significance. PMID: 1373678 Ref: Estradiol is trophic for colon cancer in mice: effect on ornithine decarboxylase and c-myc messenger RNA. PMID: 1451976 Ref: A serine protease-inhibitory benzamidine derivative inhibits the growth of human colon carcinoma cells. PMID: 1517149 Ref: Colonic aberrant crypt foci are associated with increased expression of c-fos: the possible role of modified c-fos expression in preneoplastic lesions in colon cancer. PMID: 1576709 |
Ref: Immunohistochemical detection of RAS, JUN, FOS, and p53 oncoprotein expression in human colorectal adenomas and carcinomas. PMID: 8264230 Ref: [Detection of drug resistant-genes in cisplatin-resistant colon carcinoma cells by RT-PCR assay. II]. PMID: 8361021 Ref: Ubiquitin-ribosomal protein S27a gene overexpressed in human colorectal carcinoma is an early growth response gene. PMID: 8385574 Ref: Effects of all-trans retinoic acid as a potential chemopreventive agent on the formation of azoxymethane-induced aberrant crypt foci: differential expression of c-myc and c-fos MRNA and protein. PMID: 8449605 Ref: Regulation of C-fos expression by sodium butyrate in the human colon carcinoma cell line Caco-2. PMID: 8503924 Ref: Chromosomal alterations in permanently differentiated ht29 colon-carcinoma cells induced with sodium-butyrate. PMID: 21573345 |
Ref: c-myc mRNA overexpression is associated with lymph node metastasis in colorectal cancer. PMID: 7654441 Ref: Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia. PMID: 8065332 |
Ref: Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin. PMID: 7579691 Ref: Expression of proliferation-specific genes in the mucosa adjacent to colon carcinoma. PMID: 7736875 |
Ref: Induction of apoptosis by c-Fos protein. PMID: 8524298 Ref: Increased c-fos mRNA and binding to the AP-1 recognition sequence accompanies the proliferative response to deoxycholate of HT29 cells. PMID: 8631126 Ref: Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids. PMID: 8631127 Ref: Differential effect of interleukin-4 and transforming growth factor beta 1 on expression of proto-oncogenes and autocrine insulin-like growth factor II in colorectal carcinoma cells. PMID: 8645306 Ref: Expression of protooncogene-encoded mRNA by colonic epithelial cells in inflammatory bowel disease. PMID: 8674385 Ref: Requirement of an upstream AP-1 motif for the constitutive and phorbol ester-inducible expression of the urokinase-type plasminogen activator receptor gene. PMID: 8798512 Ref: Activating protein-1 cooperates with phorbol ester activation signals to increase HIV-1 expression. PMID: 8828738 Ref: In vivo crypt surface hyperproliferation is decreased by butyrate and increased by deoxycholate in normal rat colon: associated in vivo effects on c-Fos and c-Jun expression. PMID: 8865104 Ref: Stress responses to DNA damaging agents in the human colon carcinoma cell line, RKO. PMID: 8950345 Ref: Effect of cytochrome P450 inducers on expression of oncogenes and a tumor suppressor gene in human colon cancer cells. PMID: 21541530 |
Ref: Reversal of cisplatin resistance in vivo by an anti-fos ribozyme. PMID: 9239514 |
Ref: Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. PMID: 9418904 Ref: Momordins inhibit both AP-1 function and cell proliferation. PMID: 9568065 Ref: Signal transduction mechanisms in neurotensin-mediated cellular regulation. PMID: 9706144 Ref: Butyrate inhibits colon carcinoma cell growth through two distinct pathways. PMID: 9706145 Ref: Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts. PMID: 9719459 Ref: Improved survival in patients with advanced colorectal carcinoma failing 5-fluorouracil who received irinotecan hydrochloride and have high intratumor C-fos expression. PMID: 9781601 |
Ref: Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras. PMID: 9926923 Ref: Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells. PMID: 10344756 Ref: A region between -141 and -61 bp containing a proximal AP-1 is essential for constitutive expression of urokinase-type plasminogen activator receptor. PMID: 10447677 Ref: Targeted disruption of the K-ras oncogene in an invasive colon cancer cell line down-regulates urokinase receptor expression and plasminogen-dependent proteolysis. PMID: 10471035 Ref: Oncoprotein coexpression in human aberrant crypt foci and minute polypoid lesions of the large bowel. PMID: 10652634 Ref: Regulatory effect and mechanism of gastrin and its antagonists on colorectal carcinoma. PMID: 11819478 |
Ref: Bile acid-induced activation of activator protein-1 requires both extracellular signal-regulated kinase and protein kinase C signaling. PMID: 10748108 Ref: Effects of specific bile acids on c-fos messenger RNA levels in human colon carcinoma Caco-2 cells. PMID: 11033072 Ref: Differential effects of theaflavin monogallates on cell growth, apoptosis, and Cox-2 gene expression in cancerous versus normal cells. PMID: 11103814 Ref: VPAC1 receptors and lung cancer. PMID: 11193832 Ref: Recent studies on the biofunctions and biotransformations of curcumin. PMID: 11237176 |
Ref: Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells. PMID: 11292836 Ref: Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells. PMID: 11323387 Ref: Mechanisms of cancer chemoprevention by curcumin. PMID: 11370761 Ref: A buckwheat protein product suppresses 1,2-dimethylhydrazine-induced colon carcinogenesis in rats by reducing cell proliferation. PMID: 11385078 Ref: Cell proliferation in cancer prevention; effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cells. PMID: 11506814 Ref: High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin. PMID: 11605002 Ref: Nitric oxide and endothelin-1,2 in actinic keratosis and basal cell carcinoma: changes in nitric oxide/endothelin ratio. PMID: 11737437 |
Ref: Activation of the Wnt pathway interferes with serum response element-driven transcription of immediate early genes. PMID: 11751871 Ref: Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. PMID: 11875501 |
Ref: Antitumor effect of vitamin B6 and its mechanisms. PMID: 12686121 Ref: Impact of p53 knockout and topotecan treatment on gene expression profiles in human colon carcinoma cells: a pharmacogenomic study. PMID: 12782583 Ref: Expression profiling of CC531 colon carcinoma cells reveals similar regulation of beta-catenin target genes by both butyrate and aspirin. PMID: 12800193 Ref: Tumor suppressor function of Betaig-h3 gene in radiation carcinogenesis. PMID: 12971413 Ref: Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells. PMID: 14625389 |
Ref: The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway. PMID: 14729633 Ref: Folic acid-mediated inhibition of serum-induced activation of EGFR promoter in colon cancer cells. PMID: 15075253 Ref: The colon mitosis inhibitor pyroglutamyl-histidyl-glycine inhibits growth of non-tumorigenic colonic epithelial cells. PMID: 15160998 Ref: Transcriptional responses to epigallocatechin-3 gallate in HT 29 colon carcinoma spheroids. PMID: 15265009 Ref: Altered vegetable intake affects pivotal carcinogenesis pathways in colon mucosa from adenoma patients and controls. PMID: 15271855 Ref: The HIV protease inhibitor ritonavir synergizes with butyrate for induction of apoptotic cell death and mediates expression of heme oxygenase-1 in DLD-1 colon carcinoma cells. PMID: 15504750 Ref: Gene expression profiles of colorectal carcinoma in response to neo-adjuvant chemotherapy. PMID: 15547701 |
Ref: Bile acid induced gene expression in LT97 colonic adenoma cells. PMID: 15582199 Ref: Epidermal growth factor receptor gene polymorphisms predict pelvic recurrence in patients with rectal cancer treated with chemoradiation. PMID: 15701846 Ref: Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway. PMID: 15757891 Ref: (-)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells. PMID: 15814656 Ref: (-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells. PMID: 15860507 Ref: Differential expression of the AP-1 transcription factor family members in human colorectal epithelial and neuroendocrine neoplasms. PMID: 15923159 Ref: Molecular markers that predict response to colon cancer therapy. PMID: 15934813 Ref: Valine-286 residue in the third intracellular loop of the cholecystokinin 2 receptor exerts a pivotal role in cholecystokinin 2 receptor mediated intracellular signal transduction in human colon cancer cells. PMID: 15951156 Ref: The Fos family of transcription factors and their role in tumourigenesis. PMID: 16199154 Ref: Immunoprofiles of 11 biomarkers using tissue microarrays identify prognostic subgroups in colorectal cancer. PMID: 16207476 Ref: Effect of the farnesyl transferase inhibitor L-744,832 on the colon cancer cell line DLD-1 and its combined use with radiation and 5-FU. PMID: 16224182 Ref: AP-1 and colorectal cancer. PMID: 16259733 Ref: Combination analysis of activator protein-1 family members, Sp1 and an activator protein-2alpha-related factor binding to different regions of the urokinase receptor gene in resected colorectal cancers. PMID: 16361535 |
Ref: T cell deficiency leads to liver carcinogenesis in azoxymethane-treated rats. PMID: 16380649 Ref: c-Fos is required for TGFbeta1 production and the associated paracrine migratory effects of human colon carcinoma cells. PMID: 16637060 |
Ref: Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventive agent. PMID: 17371277 Ref: Gene profile analysis of colorectal cancer cell lines by cDNA macroarray. PMID: 17390045 Ref: 2-hydroxycinnamaldehyde inhibits SW620 colon cancer cell growth through AP-1 inactivation. PMID: 17510524 Ref: Inhibitory effect of phytoglycoprotein on tumor necrosis factor-alpha and interleukin-6 at initiation stage of colon cancer in 1,2-dimethylhydrazine-treated ICR mice. PMID: 17868752 Ref: EGF-R is expressed and AP-1 and NF-kappaB are activated in stromal myofibroblasts surrounding colon adenocarcinomas paralleling expression of COX-2 and VEGF. PMID: 18032824 |
Ref: Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB. PMID: 18241858 Ref: The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice. PMID: 18679426 Ref: Tumor necrosis factor alpha activates transcription of the NADPH oxidase organizer 1 (NOXO1) gene and upregulates superoxide production in colon epithelial cells. PMID: 18929641 Ref: Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. PMID: 18936204 |
Ref: Inhibition of cyclooxygenase-1 lowers proliferation and induces macroautophagy in colon cancer cells. PMID: 19258012 Ref: MAP kinases in proliferating human colon cancer Caco-2 cells. PMID: 19301097 Ref: Methylation status of CpG islands in the promoter region of genes differentially expressed in colonic mucosa from adenoma patients and controls in response to altered vegetable intake. PMID: 19434801 Ref: Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins. PMID: 19437480 Ref: NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin D1 in human colorectal cancer. PMID: 19499154 Ref: FOS proliferating network construction in early colorectal cancer (CRC) based on integrative significant function cluster and inferring analysis. PMID: 19557575 |
Ref: Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction. PMID: 20068171 Ref: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway. PMID: 20136087 Ref: Epigenetic regulation of the ERbeta gene on the estrogen signal transfection pathway in colon cancer cells. PMID: 20155458 Ref: Selective suicide gene therapy of colon cancer exploiting the urokinase plasminogen activator receptor promoter. PMID: 20199127 Ref: Signal transduction pathways associated with ATP-induced proliferation of colon adenocarcinoma cells. PMID: 20562007 Ref: Oncogenic KRAS desensitizes colorectal tumor cells to epidermal growth factor receptor inhibition and activation. PMID: 20563247 Ref: Effect of soy saponin on the growth of human colon cancer cells. PMID: 20632438 Ref: Proteomic profiling of human colon cancer cells treated with the histone deacetylase inhibitor belinostat. PMID: 20717991 |
Ref: Regulation of Nur77 expression by beta-catenin and its mitogenic effect in colon cancer cells. PMID: 20847229 Ref: Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis. PMID: 21147860 Ref: Dimerumic acid inhibits SW620 cell invasion by attenuating H(2)O(2)-mediated MMP-7 expression via JNK/C-Jun and ERK/C-Fos activation in an AP-1-dependent manner. PMID: 21814482 Ref: Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice. PMID: 21822537 Ref: Molecular changes consistent with increased proliferation and invasion are common in rectal cancer. PMID: 21975339 |
Ref: Knockdown of c-Fos suppresses the growth of human colon carcinoma cells in athymic mice. PMID: 21344377 Ref: Tissue factor/activated factor VIIa induces matrix metalloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell. PMID: 22076613 Ref: VDR/RXR and TCF4/beta-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression. PMID: 22108803 Ref: Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging. PMID: 22465936 Ref: Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathway. PMID: 22685297 Ref: Transcriptional regulation of PES1 expression by c-Jun in colon cancer. PMID: 22860098 Ref: Role of plasminogen activator inhibitor-1 in urokinase's paradoxical in vivo tumor suppressing or promoting effects. PMID: 22912336 Ref: PAX2 protein induces expression of cyclin D1 through activating AP-1 protein and promotes proliferation of colon cancer cells. PMID: 23135283 Ref: Butyrate produced by commensal bacteria potentiates phorbol esters induced AP-1 response in human intestinal epithelial cells. PMID: 23300800 |
Ref: Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation. PMID: 22965873 Ref: Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a. PMID: 22978663 Ref: 6 Iodo-delta-lactone: a derivative of arachidonic acid with antitumor effects in HT-29 colon cancer cells. PMID: 23375358 Ref: CD24 induces expression of the oncomir miR-21 via Src, and CD24 and Src are both post-transcriptionally downregulated by the tumor suppressor miR-34a. PMID: 23533633 Ref: Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer. PMID: 23588207 Ref: S100P/RAGE signaling regulates microRNA-155 expression via AP-1 activation in colon cancer. PMID: 23693020 Ref: Phosphoglycerate kinase 1 as a promoter of metastasis in colon cancer. PMID: 23727790 Ref: The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful peripheral neuropathy. PMID: 24152430 Ref: AP-1 Gene Expression Levels May Be Correlated with Changes in Gene Expression of Some Stemness Factors in Colon Carcinomas. PMID: 24396595 |
Ref: Characterization of acute and chronic neuropathies induced by oxaliplatin in mice and differential effects of a novel mitochondria-targeted antioxidant on the neuropathies. PMID: 24064792 Ref: Effect of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine on oxidative stress and gene expression of c-fos, c-jun, p16 and Rb in rat colons and protective role of seabuckthorn seed oil. PMID: 24502215 Ref: KRAS and YAP1 converge to regulate EMT and tumor survival. PMID: 24954536 Ref: Cytotoxicity of Eupatorium cannabinum L. ethanolic extract against colon cancer cells and interactions with Bisphenol A and Doxorubicin. PMID: 25056133 Ref: AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion. PMID: 25080976 Ref: Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia. PMID: 25539728 |
Ref: PKC/MEK inhibitors suppress oxaliplatin-induced neuropathy and potentiate the antitumor effects. PMID: 25430564 Ref: The membrane protein melanoma cell adhesion molecule (MCAM) is a novel tumor marker that stimulates tumorigenesis in hepatocellular carcinoma. PMID: 25728681 Ref: [Appropriate dosing of fosaprepitant for colon cancer patients]. PMID: 25743141 Ref: Antineoplastic effect of a novel chemopreventive agent, neokestose, on the Caco-2 cell line via inhibition of expression of nuclear factor-kappaB and cyclooxygenase-2. PMID: 25815878 Ref: Gene expression profile analysis of colorectal cancer to investigate potential mechanisms using bioinformatics. PMID: 25914544 Ref: The S100P/RAGE signaling pathway regulates expression of microRNA-21 in colon cancer cells. PMID: 26193421 Ref: Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascular Endothelial Growth Factor A in Colon Cancer Cells and Induce Angiogenesis. PMID: 26209639 Ref: An Integrative Approach for Mapping Differentially Expressed Genes and Network Components Using Novel Parameters to Elucidate Key Regulatory Genes in Colorectal Cancer. PMID: 26222778 Ref: Epibrassinolide alters PI3K/MAPK signaling axis via activating Foxo3a-induced mitochondria-mediated apoptosis in colon cancer cells. PMID: 26318418 Ref: Bisphenol A at the reference level counteracts doxorubicin transcriptional effects on cancer related genes in HT29 cells. PMID: 26320837 Ref: Revealing potential molecular targets bridging colitis and colorectal cancer based on multidimensional integration strategy. PMID: 26461477 Ref: Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival. PMID: 26646695 |
Ref: Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway. PMID: 26028036 Ref: Histone deacetylase 2 regulates doxorubicin (Dox) sensitivity of colorectal cancer cells by targeting ABCB1 transcription. PMID: 26846508 Ref: Time course analysis based on gene expression profile and identification of target molecules for colorectal cancer. PMID: 27013928 Ref: Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer. PMID: 27428427 Ref: gamma-Aminobutyric acid inhibits the proliferation and increases oxaliplatin sensitivity in human colon cancer cells. PMID: 27644246 |
Ref: Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors. PMID: 27597531 Ref: p38 and JNK pathways control E-selectin-dependent extravasation of colon cancer cells by modulating miR-31 transcription. PMID: 27926494 Ref: Morin and Esculetin supplementation modulates c-myc induced energy metabolism and attenuates neoplastic changes in rats challenged with the procarcinogen 1,2 - dimethylhydrazine. PMID: 27989504 Ref: The genetic basis of obesity complications. PMID: 28362475 Ref: ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types. PMID: 28611196 Ref: A Deregulated PI3K-AKT Signaling Pathway in Patients with Colorectal Cancer. PMID: 29110225 |
Ref: p38 activation induces production of miR-146a and miR-31 to repress E-selectin expression and inhibit transendothelial migration of colon cancer cells. PMID: 29402939 |