Primary Site >> Pancreatic Cancer
Gene >> FN1
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Ref: Plasma fibronectin in normal subjects and in various disease states. PMID: 7251892 Ref: Attachment of human pancreatic tumor cell lines to collagen in vitro. PMID: 7260895 |
Ref: Cysteine proteinases and metastasis. PMID: 6093995 |
Ref: Diversity of adhesion to basement membrane components of human pancreatic adenocarcinomas. PMID: 2932215 |
Ref: Distribution of extracellular matrix proteins in pancreatic ductal adenocarcinoma and its influence on tumor cell proliferation in vitro. PMID: 3554225 |
Ref: Characterization of integrin chains in normal and neoplastic human pancreas. PMID: 1720170 Ref: Tumor-associated trypsin participates in cancer cell-mediated degradation of extracellular matrix. PMID: 2009530 |
Ref: Expression and function of VLA-alpha 2, -alpha 3, -alpha 5 and -alpha 6-integrin receptors in pancreatic carcinoma. PMID: 1330937 Ref: Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein. PMID: 1532572 Ref: Monoclonal antibodies against 5'-nucleotidase from a human pancreatic tumor cell line: their characterization and inhibitory capacity on tumor cell adhesion to fibronectin substratum. PMID: 1644065 |
Ref: Expression and distribution of VLA receptors in the pancreas: an immunohistochemical study. PMID: 8255885 |
Ref: A monoclonal antibody inhibits adhesion to fibronectin and vitronectin of a colon carcinoma cell line and recognizes the integrins alpha v beta 3, alpha v beta 5, and alpha v beta 6. PMID: 7513610 Ref: Extracellular matrix components regulating glandular differentiation and the formation of basal lamina of a human pancreatic cancer cell line in vitro. PMID: 8143763 Ref: [Fibronectin in human bile--a new parameter for diagnosis of malignant bile duct processes?--A pilot study]. PMID: 8165831 |
Ref: [Role of tripeptide Arg-Gly-Asp (RGD) on adhesiveness of human pancreatic cancer cell, PANC-1 to extracellular matrix]. PMID: 7630002 Ref: Expression and in-situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer. PMID: 7635566 Ref: Characterization of cancer cell dissociation factor in a highly invasive pancreatic cancer cell line. PMID: 7889490 Ref: A novel adhesion factor produced by hamster pancreatic cancer cell line is effective on normal and carcinoma cell lines of different species. PMID: 8708397 |
Ref: Expression and function of receptors for extracellular matrix proteins in human ductal adenocarcinomas of the pancreas. PMID: 8830331 |
Ref: [Predisposition of subclones of pancreatic carcinoma cells, AsPC-1, to changes in functional and histopathological features of xenograft tumors with response to extracellular matrix]. PMID: 9128054 Ref: Modified cytokeratins expressed on the surface of carcinoma cells undergo endocytosis upon binding of human monoclonal antibody and its recombinant Fab fragment. PMID: 9223323 |
Ref: Integrin alpha6beta1 role in metastatic behavior of human pancreatic carcinoma cells. PMID: 10048983 Ref: Activated lansoprazole inhibits cancer cell adhesion to extracellular matrix components. PMID: 10375591 Ref: Cytokines modulate MIA PaCa 2 and CAPAN-1 adhesion to extracellular matrix proteins. PMID: 10547196 |
Ref: Beta1 integrins play an essential role in adhesion and invasion of pancreatic carcinoma cells. PMID: 10707927 |
Ref: Thrombin enhances adhesion in pancreatic cancer in vitro through the activation of the thrombin receptor PAR 1. PMID: 11504518 |
Ref: TGFbeta-induced fibrogenesis of the pancreas. PMID: 12622414 |
Ref: Immunocytes and activated stellate cells in pancreatic fibrogenesis. PMID: 12657949 Ref: Cell adhesion-mediated radioresistance (CAM-RR). Extracellular matrix-dependent improvement of cell survival in human tumor and normal cells in vitro. PMID: 12740661 Ref: CD44v10: an antimetastatic membrane glycoprotein for pancreatic cancer. PMID: 12841682 Ref: Extracellular matrix proteins protect pancreatic cancer cells from death via mitochondrial and nonmitochondrial pathways. PMID: 14517801 Ref: Aspirin inhibits highly invasive prostate cancer cells. PMID: 14532966 |
Ref: Tumor-stroma interaction of human pancreatic cancer: acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins. PMID: 14707728 Ref: The extracellular matrix differentially regulates the expression of PTHrP and the PTH/PTHrP receptor in FG pancreatic cancer cells. PMID: 15257098 Ref: Immunohistochemical screening for beta6-integrin subunit expression in adenocarcinomas using a novel monoclonal antibody reveals strong up-regulation in pancreatic ductal adenocarcinomas in vivo and in vitro. PMID: 15330800 Ref: Latent effects of fibronectin, alpha5beta1 integrin, alphaVbeta5 integrin and the cytoskeleton regulate pancreatic carcinoma cell IL-8 secretion. PMID: 15354211 Ref: Pancreatic cancer stimulates pancreatic stellate cell proliferation and TIMP-1 production through the MAP kinase pathway. PMID: 15451430 |
Ref: Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways. PMID: 15696124 Ref: Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. PMID: 15825074 Ref: Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase. PMID: 16037546 Ref: Pancreatic cancer cells invasiveness is mainly affected by interleukin-1beta not by transforming growth factor-beta1. PMID: 16398405 Ref: Type I collagen and divalent cation shifts disrupt cell-cell adhesion, increase migration, and decrease PTHrP, IL-6, and IL-8 expression in pancreatic cancer cells. PMID: 16720909 |
Ref: The alpha2beta1 integrin mediates the malignant phenotype on type I collagen in pancreatic cancer cell lines. PMID: 16622460 Ref: RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells. PMID: 16707592 |
Ref: Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity. PMID: 17408641 Ref: Potentiated antitumor effects of the combination treatment with statins and pamidronate in vitro and in vivo. PMID: 17487362 Ref: Integrin-mediated laminin-1 adhesion upregulates CXCR4 and IL-8 expression in pancreatic cancer cells. PMID: 17560257 Ref: Insulin-like growth factor-I receptor mediates the prosurvival effect of fibronectin. PMID: 17627944 Ref: Epithelial-mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer. PMID: 17879119 Ref: High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition. PMID: 17997817 |
Ref: Basement membrane proteins play an important role in the invasive processes of human pancreatic cancer cells. PMID: 17688882 Ref: The targeted immunocytokine L19-IL2 efficiently inhibits the growth of orthotopic pancreatic cancer. PMID: 18676770 Ref: Divalent cations modulate the integrin-mediated malignant phenotype in pancreatic cancer cells. PMID: 18754866 Ref: Expression of kallikrein 7 diminishes pancreatic cancer cell adhesion to vitronectin and enhances urokinase-type plasminogen activator receptor shedding. PMID: 18953252 |
Ref: Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines. PMID: 18844224 Ref: The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cells. PMID: 19029090 Ref: Extended-working-distance multiphoton micromanipulation microscope for deep-penetration imaging in live mice and tissue. PMID: 19405761 Ref: Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma. PMID: 19412434 Ref: Alterations in integrin expression modulates invasion of pancreatic cancer cells. PMID: 19825166 Ref: Promotion of tumor cell migration by extracellular matrix proteins in human pancreatic cancer. PMID: 19893454 Ref: Expression of matrix metalloproteinase-26 in multiple human cancer tissues and smooth muscle cells. PMID: 19895737 |
Ref: Enhanced expression of lumican inhibited the attachment and growth of human embryonic kidney 293 cells. PMID: 20138170 Ref: Antitumor effects of EMAP II against pancreatic cancer through inhibition of fibronectin-dependent proliferation. PMID: 20212356 Ref: Interaction of stellate cells with pancreatic carcinoma cells. PMID: 24281180 |
Ref: Overexpression of fibroblast growth factor receptor 4 in high-grade pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma. PMID: 21109934 Ref: Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells. PMID: 21464039 Ref: Knockdown of the beta(1) integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis. PMID: 21491421 Ref: FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells. PMID: 21668992 Ref: Tenascin-C enhances pancreatic cancer cell growth and motility and affects cell adhesion through activation of the integrin pathway. PMID: 21747918 Ref: MUC6 mucin expression inhibits tumor cell invasion. PMID: 21851820 Ref: Role of alpha(5)beta(1) Integrin Up-regulation in Radiation-Induced Invasion by Human Pancreatic Cancer Cells. PMID: 21966545 Ref: [Regulatory mechanisms of Hedgehog signaling pathway for epithelial-mesenchymal transition in pancreatic cancer cells]. PMID: 22340649 |
Ref: Establishment of a highly migratory subclone reveals that CD133 contributes to migration and invasion through epithelial-mesenchymal transition in pancreatic cancer. PMID: 22109279 Ref: Suppression of the epidermal growth factor receptor inhibits epithelial-mesenchymal transition in human pancreatic cancer PANC-1 cells. PMID: 22271412 Ref: Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis. PMID: 22457533 Ref: Synthesis and evaluation of curcumin-related compounds for anticancer activity. PMID: 22551677 Ref: Thrombin stimulates integrin beta1-dependent adhesion of human pancreatic cancer cells to vitronectin through protease-activated receptor (PAR)-1. PMID: 22683980 |
Ref: Grape seed proanthocyanidins inhibit migration potential of pancreatic cancer cells by promoting mesenchymal-to-epithelial transition and targeting NF-kappaB. PMID: 22902508 Ref: Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells. PMID: 23348422 Ref: Modulation of pancreatic tumor potential by overexpression of protein kinase C beta1. PMID: 23695799 Ref: Application of concave microwells to pancreatic tumor spheroids enabling anticancer drug evaluation in a clinically relevant drug resistance model. PMID: 24039920 Ref: RhoC interacts with integrin alpha5beta1 and enhances its trafficking in migrating pancreatic carcinoma cells. PMID: 24312560 |
Ref: Pancreatic stellate cells promote hapto-migration of cancer cells through collagen I-mediated signalling pathway. PMID: 24201748 Ref: Micropallet arrays for the capture, isolation and culture of circulating tumor cells from whole blood of mice engrafted with primary human pancreatic adenocarcinoma. PMID: 24316450 Ref: miR-203 inhibits tumor cell migration and invasion via caveolin-1 in pancreatic cancer cells. PMID: 24520289 Ref: miR-208-induced epithelial to mesenchymal transition of pancreatic cancer cells promotes cell metastasis and invasion. PMID: 24604208 Ref: The role of quantitative mass spectrometry in the discovery of pancreatic cancer biomarkers for translational science. PMID: 24708694 |
Ref: Transcriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesis. PMID: 24561527 Ref: Extracellular calumenin suppresses ERK1/2 signaling and cell migration by protecting fibulin-1 from MMP-13-mediated proteolysis. PMID: 24632605 Ref: The epithelial to mesenchymal transition in pancreatic cancer: A systematic review. PMID: 25794655 Ref: Analysis of molecular pathways in pancreatic ductal adenocarcinomas with a bioinformatics approach. PMID: 25824797 Ref: Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. PMID: 25985394 Ref: Suppression of the Epidermal Growth Factor-like Domain 7 and Inhibition of Migration and Epithelial-Mesenchymal Transition in Human Pancreatic Cancer PANC-1 Cells. PMID: 25987088 |
Ref: Matrix control of pancreatic cancer: New insights into fibronectin signaling. PMID: 26742464 Ref: MYB Promotes Desmoplasia in Pancreatic Cancer through Direct Transcriptional Up-regulation and Cooperative Action of Sonic Hedgehog and Adrenomedullin. PMID: 27246849 Ref: Hypoxia and Transforming Growth Factor beta Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer. PMID: 27531748 Ref: The Effect of Size and Geometry of Poly(acrylamide) Brush-Based Micropatterns on the Behavior of Cells. PMID: 27541003 |
Ref: Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells. PMID: 27750041 Ref: Oridonin inhibition and miR200b3p/ZEB1 axis in human pancreatic cancer. PMID: 27878247 Ref: Alpha-enolase (ENO1) controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis. PMID: 28086938 Ref: The nuclear orphan receptor NR4A1 regulates beta1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists. PMID: 28418095 Ref: Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. PMID: 29021221 Ref: Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway. PMID: 29072694 |
Ref: Potent antitumor effect of tumor microenvironment-targeted oncolytic adenovirus against desmoplastic pancreatic cancer. PMID: 28929492 Ref: Pseudolaric Acid B Inhibits Proliferation, Invasion and Epithelial-to-Mesenchymal Transition in Human Pancreatic Cancer Cell. PMID: 29214772 Ref: Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma. PMID: 29303405 Ref: Regulation of pancreatic stellate cell activation by Notch3. PMID: 29304760 Ref: Galectin-1 expression in activated pancreatic satellite cells promotes fibrosis in chronic pancreatitis/pancreatic cancer via the TGF-beta1/Smad pathway. PMID: 29328490 Ref: Multicellular spheroid based on a triple co-culture: A novel 3D model to mimic pancreatic tumor complexity. PMID: 30099198 Ref: Designer hydrogels: Shedding light on the physical chemistry of the pancreatic cancer microenvironment. PMID: 30118843 |